George Little is in de wolken: zijn ouders hebben besloten een broertje te adopteren. In het weeshuis bezwijken Mr. en Mrs. Little echter voor de charmes van een witte muis. Ze adopteren het beestje en dopen het Stuart. George is ontgoocheld met zijn nieuwe vriendje. Snowbell, de angorakater van het gezin, ziet Stuart wel zitten en beraamt met de katten uit de buurt een duivels plan om voorgoed met hem af te rekenen.
| Production | Douglas Wick | Producer |
| Camera | Guillermo Navarro | Director of Photography |
| Writing | Greg Brooker | Screenplay |
| Editing | Tom Finan | Editor |
| Writing | M. Night Shyamalan | Screenplay |
| Directing | Rob Minkoff | Director |
| Sound | Patricia Rodríguez | Loop Group Coordinator |
| Costume & Make-Up | Beth Miller | Key Hair Stylist |
| Visual Effects | Robin Griffin | Visual Effects Producer |
| Production | Steve Waterman | Executive Producer |
| Costume & Make-Up | Joseph A. Porro | Costume Design |
| Costume & Make-Up | Bonita DeHaven | Key Makeup Artist |
| Directing | John Dykstra | Second Unit Director |
| Production | Debra Zane | Casting Director |
| Production | Jeff Franklin | Executive Producer |
| Sound | Larry Mann | Supervising Sound Editor |
| Editing | Julie Rogers | Editor |
| Costume & Make-Up | Mindy Hall | Makeup Artist |
| Crew | Linda Drake | Visual Effects Editor |
| Costume & Make-Up | Christina Raye | Hairstylist |
| Crew | Christer Hokanson | Visual Effects Editor |
| Visual Effects | David Kindlon | Mechanical Designer |
| Sound | Kenneth Karman | Music Editor |
| Art | Bill Brzeski | Production Design |
| Visual Effects | Henry F. Anderson III | Animation Supervisor |
| Production | Jason Clark | Executive Producer |
| Sound | Elliot Lurie | Music Supervisor |
| Visual Effects | John Dykstra | Senior Visual Effects Supervisor |
| Art | Philip Toolin | Art Direction |
| Art | Clay A. Griffith | Set Decoration |
| Sound | Alan Silvestri | Original Music Composer |
| Visual Effects | Patrick Tatopoulos | Creature Design |
| Crew | Tony R. Medina | Propmaker |
| Visual Effects | Jerome Chen | Visual Effects Supervisor |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Camera | Wally Pfister | Camera Operator |
| Writing | E.B. White | Novel |
