George Little is in de wolken: zijn ouders hebben besloten een broertje te adopteren. In het weeshuis bezwijken Mr. en Mrs. Little echter voor de charmes van een witte muis. Ze adopteren het beestje en dopen het Stuart. George is ontgoocheld met zijn nieuwe vriendje. Snowbell, de angorakater van het gezin, ziet Stuart wel zitten en beraamt met de katten uit de buurt een duivels plan om voorgoed met hem af te rekenen.
| Writing | M. Night Shyamalan | Screenplay |
| Production | Douglas Wick | Producer |
| Writing | Greg Brooker | Screenplay |
| Editing | Tom Finan | Editor |
| Camera | Guillermo Navarro | Director of Photography |
| Directing | Rob Minkoff | Director |
| Sound | Patricia Rodríguez | Loop Group Coordinator |
| Sound | Kenneth Karman | Music Editor |
| Costume & Make-Up | Joseph A. Porro | Costume Design |
| Production | Jeff Franklin | Executive Producer |
| Costume & Make-Up | Beth Miller | Key Hair Stylist |
| Crew | Christer Hokanson | Visual Effects Editor |
| Production | Debra Zane | Casting Director |
| Costume & Make-Up | Christina Raye | Hairstylist |
| Costume & Make-Up | Mindy Hall | Makeup Artist |
| Crew | Linda Drake | Visual Effects Editor |
| Editing | Julie Rogers | Editor |
| Sound | Larry Mann | Supervising Sound Editor |
| Visual Effects | David Kindlon | Mechanical Designer |
| Art | Clay A. Griffith | Set Decoration |
| Production | Jason Clark | Executive Producer |
| Art | Philip Toolin | Art Direction |
| Production | Steve Waterman | Executive Producer |
| Sound | Elliot Lurie | Music Supervisor |
| Visual Effects | Robin Griffin | Visual Effects Producer |
| Visual Effects | Henry F. Anderson III | Animation Supervisor |
| Art | Bill Brzeski | Production Design |
| Costume & Make-Up | Bonita DeHaven | Key Makeup Artist |
| Directing | John Dykstra | Second Unit Director |
| Visual Effects | John Dykstra | Senior Visual Effects Supervisor |
| Sound | Alan Silvestri | Original Music Composer |
| Visual Effects | Patrick Tatopoulos | Creature Design |
| Crew | Tony R. Medina | Propmaker |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Visual Effects | Jerome Chen | Visual Effects Supervisor |
| Camera | Wally Pfister | Camera Operator |
| Writing | E.B. White | Novel |
| Crew | Scott Stokdyk | CG Supervisor |
