George Little is in de wolken: zijn ouders hebben besloten een broertje te adopteren. In het weeshuis bezwijken Mr. en Mrs. Little echter voor de charmes van een witte muis. Ze adopteren het beestje en dopen het Stuart. George is ontgoocheld met zijn nieuwe vriendje. Snowbell, de angorakater van het gezin, ziet Stuart wel zitten en beraamt met de katten uit de buurt een duivels plan om voorgoed met hem af te rekenen.
| Directing | Rob Minkoff | Director |
| Writing | M. Night Shyamalan | Screenplay |
| Writing | Greg Brooker | Screenplay |
| Production | Douglas Wick | Producer |
| Camera | Guillermo Navarro | Director of Photography |
| Editing | Tom Finan | Editor |
| Sound | Patricia Rodríguez | Loop Group Coordinator |
| Production | Debra Zane | Casting Director |
| Visual Effects | John Dykstra | Senior Visual Effects Supervisor |
| Costume & Make-Up | Joseph A. Porro | Costume Design |
| Art | Bill Brzeski | Production Design |
| Production | Jeff Franklin | Executive Producer |
| Production | Steve Waterman | Executive Producer |
| Production | Jason Clark | Executive Producer |
| Visual Effects | Henry F. Anderson III | Animation Supervisor |
| Editing | Julie Rogers | Editor |
| Art | Philip Toolin | Art Direction |
| Art | Clay A. Griffith | Set Decoration |
| Costume & Make-Up | Bonita DeHaven | Key Makeup Artist |
| Costume & Make-Up | Mindy Hall | Makeup Artist |
| Costume & Make-Up | Beth Miller | Key Hair Stylist |
| Costume & Make-Up | Christina Raye | Hairstylist |
| Directing | John Dykstra | Second Unit Director |
| Sound | Larry Mann | Supervising Sound Editor |
| Crew | Linda Drake | Visual Effects Editor |
| Crew | Christer Hokanson | Visual Effects Editor |
| Visual Effects | Robin Griffin | Visual Effects Producer |
| Visual Effects | David Kindlon | Mechanical Designer |
| Sound | Elliot Lurie | Music Supervisor |
| Sound | Kenneth Karman | Music Editor |
| Sound | Alan Silvestri | Original Music Composer |
| Writing | E.B. White | Author |
| Visual Effects | Patrick Tatopoulos | Creature Design |
| Crew | Tony R. Medina | Propmaker |
| Visual Effects | Jerome Chen | Visual Effects Supervisor |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Camera | Wally Pfister | Camera Operator |
