Dale Denton (Seth Rogen), een luie wietroker, heeft maar één reden om zijn even luie dealer Saul Silver (James Franco) op te zoeken: om wiet te kopen, vooral het zeldzame 'Pineapple Express'. Als hij getuige is van een moord, die wordt gepleegd door een gewetenloze politieagent en de gevaarlijkste drugsbaron van de stad, raakt hij in paniek. Van schrik laat hij zijn 'Pineapple Express'-joint vallen. Deze is zo zeldzaam dat de moordenaars direct naar Saul en Dale worden geleid. De hallucinerende heren slaan op de vlucht en ontdekken al snel dat ze niet lijden aan achtervolgingswaanzin veroorzaakt door hun overmatige drugsgebruik...
Nee, helaas is Pineapple Express nog niet beschikbaar op Netflix in Nederland.
| Writing | Seth Rogen | Screenplay |
| Directing | David Gordon Green | Director |
| Writing | Evan Goldberg | Screenplay |
| Editing | Craig Alpert | Editor |
| Production | Judd Apatow | Producer |
| Writing | Judd Apatow | Story |
| Writing | Evan Goldberg | Story |
| Camera | Tim Orr | Director of Photography |
| Production | Shauna Robertson | Producer |
| Production | Kerry Barden | Casting |
| Costume & Make-Up | John Dunn | Costume Design |
| Production | Billy Hopkins | Casting |
| Writing | Seth Rogen | Story |
| Production | Evan Goldberg | Executive Producer |
| Production | Seth Rogen | Executive Producer |
| Directing | Lisa M. Rowe | Second Assistant Director |
| Directing | Gary Hymes | Second Unit Director |
| Costume & Make-Up | Cheryl Eckert | Hairstylist |
| Art | Marc Dabe | Art Direction |
| Costume & Make-Up | Erin Wooldridge | Key Makeup Artist |
| Production | Dara Weintraub | Co-Producer |
| Production | Dara Weintraub | Unit Production Manager |
| Directing | Lisa C. Satriano | First Assistant Director |
| Costume & Make-Up | Kimberly Greene | Makeup Supervisor |
| Crew | Tom McComas | Stunts |
| Crew | Scotty Richards | Stunt Driver |
| Directing | Nick Satriano | Second Unit First Assistant Director |
| Production | Christa Vausbinder | Production Supervisor |
| Camera | Walter 'Bud' Scott | Key Grip |
| Production | Christine Bonnem | Location Manager |
| Production | Matt V. Messina | Assistant Location Manager |
| Production | Carrie Arnold | Assistant Production Coordinator |
| Crew | Paul Leonard | Stunts |
| Camera | Sean Hunter Moe | First Assistant "B" Camera |
| Lighting | Chris Napolitano | Chief Lighting Technician |
| Camera | Steven A. Guerrero | Dolly Grip |
| Lighting | William Ambrose | Key Rigging Grip |
| Art | Michelle Spears | Property Master |
| Camera | Lawrence Karman | Steadicam Operator |
| Costume & Make-Up | Brenda M. Ware | Key Costumer |
| Production | Ricky Cuevas | Assistant Accountant |
| Art | Karen Higgins | Construction Coordinator |
| Crew | Gary Baxley | Stunts |
| Camera | Bill Coe | First Assistant Camera |
| Costume & Make-Up | Phyllis Corcoran-Woods | Costume Supervisor |
| Costume & Make-Up | Myron Baker | Costumer |
| Lighting | Kevin J. Lang | Rigging Gaffer |
| Art | Ryan Falkner | Storyboard Artist |
| Crew | David Wald | Stunts |
| Camera | Bobby McMahan | Second Assistant Camera |
| Crew | Corey Michael Eubanks | Stunts |
| Crew | Hiro Koda | Stunts |
| Crew | Eric Rylander | Special Effects Coordinator |
| Art | Thierry Labbe | Leadman |
| Crew | Debbie Evans | Stunts |
| Crew | Ed McDermott II | Stunt Driver |
| Crew | Yoshio Iizuka | Stunts |
| Sound | Knox White | Boom Operator |
| Art | Martin Milligan | Set Dresser |
| Camera | Matthew A. Petrosky | "B" Camera Operator |
| Production | Jonathan Lynch | Assistant Location Manager |
| Art | Kat Wilson | Art Department Coordinator |
| Lighting | Ron Alexus | Assistant Chief Lighting Technician |
| Production | Justin Giugno | Production Secretary |
| Production | Jill Rosenblatt | Production Accountant |
| Crew | Mark Chadwick | Stunts |
| Crew | Ray Lykins | Stunts |
| Visual Effects | John Frazier | Special Effects Supervisor |
| Art | Robert Fechtman | Assistant Art Director |
| Art | Kim Richey | Assistant Property Master |
| Crew | Laura Albert | Stunts |
| Crew | Collin Hymes | Stunts |
| Sound | Lydia Hollyfield | Utility Sound |
| Camera | Linda Källérus | Second Assistant "B" Camera |
| Production | Jeffrey Garrett | Assistant Location Manager |
| Crew | Dane Farwell | Stunts |
| Crew | Sean Graham | Stunts |
| Camera | Coleman L. Hart | Best Boy Grip |
| Camera | Greg Brooks | Dolly Grip |
| Crew | Jimmy Romano | Stunts |
| Camera | Lawrence Karman | Camera Operator |
| Costume & Make-Up | Lorraine Crossman | Costumer |
| Production | Rob Meisenholder | Assistant Accountant |
| Crew | Kym Langlie | Unit Publicist |
| Production | Chris Bustard | Extras Casting |
| Crew | Don Poole | Transportation Captain |
| Sound | Dominik Hauser | Orchestrator |
| Sound | Peter Boyer | Orchestrator |
| Sound | Tim Simonec | Orchestrator |
| Editing | Ray Neapolitan | Assistant Editor |
| Sound | Graeme Revell | Conductor |
| Camera | Buzz Feitshans IV | Second Unit Director of Photography |
| Sound | Bill Burns | Assistant Sound Editor |
| Sound | Michael O'Farrell | Supervising Sound Editor |
| Editing | Tim Mirkovich | Additional Editing |
| Production | Paul Schnee | Casting Associate |
| Production | Jennifer Ricchiazzi | Casting Associate |
| Editing | Mo Henry | Negative Cutter |
| Crew | John Orlebeck | Transportation Coordinator |
| Sound | Joe Schiff | Assistant Sound Editor |
| Sound | Graeme Revell | Original Music Composer |
| Art | Chris L. Spellman | Production Design |
| Art | Bob Kensinger | Set Decoration |
| Sound | Michael O'Farrell | Sound Re-Recording Mixer |
| Sound | David Giammarco | Sound Re-Recording Mixer |
| Sound | Cindy Marty | Sound Effects Editor |
| Crew | Gary Hymes | Stunt Coordinator |
| Production | Tom Carson | Production Coordinator |
| Sound | George H. Anderson | Supervising Sound Editor |
| Crew | Mike Smith | Stunt Coordinator |
| Production | Suzanne Smith Crowley | Casting |
| Camera | Darren Michaels | Still Photographer |
| Sound | Jonathan Karp | Music Supervisor |
| Costume & Make-Up | Melissa Yonkey | Hair Department Head |
| Directing | Ronit Ravich-Boss | Script Supervisor |
| Costume & Make-Up | Soo-Jin Yoon | Key Hair Stylist |
| Editing | Colin Patton | First Assistant Editor |
| Crew | J.J. Perry | Stunts |
| Sound | Michael Haight | Dialogue Editor |
| Sound | Larry Kemp | Supervising ADR Editor |
| Sound | Jonathan Karp | Music Editor |
| Sound | James Matheny | Dialogue Editor |
| Sound | Christof Gebert | Production Sound Mixer |
| Sound | Pamela Kahn | Foley Artist |
| Sound | Vincent Guisetti | Foley Artist |
| Sound | Kyle Rochlin | Foley Mixer |
| Sound | Howard London | ADR Mixer |
| Sound | Bruce Lacey | Foley Editor |
| Directing | Peter Dress | Second Second Assistant Director |
| Sound | Huey Lewis | Songs |
