Dale Denton (Seth Rogen), een luie wietroker, heeft maar één reden om zijn even luie dealer Saul Silver (James Franco) op te zoeken: om wiet te kopen, vooral het zeldzame 'Pineapple Express'. Als hij getuige is van een moord, die wordt gepleegd door een gewetenloze politieagent en de gevaarlijkste drugsbaron van de stad, raakt hij in paniek. Van schrik laat hij zijn 'Pineapple Express'-joint vallen. Deze is zo zeldzaam dat de moordenaars direct naar Saul en Dale worden geleid. De hallucinerende heren slaan op de vlucht en ontdekken al snel dat ze niet lijden aan achtervolgingswaanzin veroorzaakt door hun overmatige drugsgebruik...
Nee, helaas is Pineapple Express nog niet beschikbaar op Netflix in Nederland.
| Directing | David Gordon Green | Director |
| Writing | Seth Rogen | Screenplay |
| Writing | Evan Goldberg | Screenplay |
| Production | Seth Rogen | Executive Producer |
| Production | Evan Goldberg | Executive Producer |
| Camera | Tim Orr | Director of Photography |
| Editing | Craig Alpert | Editor |
| Costume & Make-Up | John Dunn | Costume Design |
| Production | Kerry Barden | Casting |
| Production | Billy Hopkins | Casting |
| Production | Judd Apatow | Producer |
| Production | Shauna Robertson | Producer |
| Writing | Judd Apatow | Story |
| Writing | Seth Rogen | Story |
| Writing | Evan Goldberg | Story |
| Production | Dara Weintraub | Co-Producer |
| Directing | Gary Hymes | Second Unit Director |
| Production | Dara Weintraub | Unit Production Manager |
| Directing | Lisa C. Satriano | First Assistant Director |
| Directing | Lisa M. Rowe | Second Assistant Director |
| Art | Marc Dabe | Art Direction |
| Costume & Make-Up | Kimberly Greene | Makeup Supervisor |
| Costume & Make-Up | Erin Wooldridge | Key Makeup Artist |
| Costume & Make-Up | Cheryl Eckert | Hairstylist |
| Crew | Laura Albert | Stunts |
| Crew | Gary Baxley | Stunts |
| Crew | Mark Chadwick | Stunts |
| Crew | Corey Michael Eubanks | Stunts |
| Crew | Debbie Evans | Stunts |
| Crew | Dane Farwell | Stunts |
| Crew | Sean Graham | Stunts |
| Crew | Collin Hymes | Stunts |
| Crew | Yoshio Iizuka | Stunts |
| Crew | Hiro Koda | Stunts |
| Crew | Paul Leonard | Stunts |
| Crew | Ray Lykins | Stunts |
| Crew | Tom McComas | Stunts |
| Crew | Ed McDermott II | Stunt Driver |
| Crew | Scotty Richards | Stunt Driver |
| Crew | Jimmy Romano | Stunts |
| Crew | David Wald | Stunts |
| Directing | Nick Satriano | Second Unit First Assistant Director |
| Production | Christa Vausbinder | Production Supervisor |
| Art | Michelle Spears | Property Master |
| Camera | Lawrence Karman | Camera Operator |
| Camera | Lawrence Karman | Steadicam Operator |
| Camera | Bill Coe | First Assistant Camera |
| Camera | Bobby McMahan | Second Assistant Camera |
| Camera | Matthew A. Petrosky | "B" Camera Operator |
| Camera | Sean Hunter Moe | First Assistant "B" Camera |
| Camera | Linda Källérus | Second Assistant "B" Camera |
| Costume & Make-Up | Phyllis Corcoran-Woods | Costume Supervisor |
| Costume & Make-Up | Brenda M. Ware | Key Costumer |
| Costume & Make-Up | Myron Baker | Costumer |
| Costume & Make-Up | Lorraine Crossman | Costumer |
| Lighting | Chris Napolitano | Chief Lighting Technician |
| Lighting | Ron Alexus | Assistant Chief Lighting Technician |
| Lighting | Kevin J. Lang | Rigging Gaffer |
| Camera | Walter 'Bud' Scott | Key Grip |
| Camera | Coleman L. Hart | Best Boy Grip |
| Camera | Greg Brooks | Dolly Grip |
| Camera | Steven A. Guerrero | Dolly Grip |
| Lighting | William Ambrose | Key Rigging Grip |
| Sound | Knox White | Boom Operator |
| Sound | Lydia Hollyfield | Utility Sound |
| Visual Effects | John Frazier | Special Effects Supervisor |
| Crew | Eric Rylander | Special Effects Coordinator |
| Production | Christine Bonnem | Location Manager |
| Production | Jeffrey Garrett | Assistant Location Manager |
| Production | Matt V. Messina | Assistant Location Manager |
| Production | Jonathan Lynch | Assistant Location Manager |
| Production | Carrie Arnold | Assistant Production Coordinator |
| Production | Justin Giugno | Production Secretary |
| Production | Jill Rosenblatt | Production Accountant |
| Production | Ricky Cuevas | Assistant Accountant |
| Production | Rob Meisenholder | Assistant Accountant |
| Art | Karen Higgins | Construction Coordinator |
| Art | Robert Fechtman | Assistant Art Director |
| Art | Ryan Falkner | Storyboard Artist |
| Art | Kat Wilson | Art Department Coordinator |
| Art | Thierry Labbe | Leadman |
| Art | Martin Milligan | Set Dresser |
| Art | Kim Richey | Assistant Property Master |
| Crew | Kym Langlie | Unit Publicist |
| Production | Paul Schnee | Casting Associate |
| Production | Jennifer Ricchiazzi | Casting Associate |
| Production | Chris Bustard | Extras Casting |
| Crew | John Orlebeck | Transportation Coordinator |
| Crew | Don Poole | Transportation Captain |
| Camera | Buzz Feitshans IV | Second Unit Director of Photography |
| Editing | Tim Mirkovich | Additional Editing |
| Editing | Ray Neapolitan | Assistant Editor |
| Sound | Michael O'Farrell | Supervising Sound Editor |
| Sound | Joe Schiff | Assistant Sound Editor |
| Sound | Bill Burns | Assistant Sound Editor |
| Sound | Graeme Revell | Conductor |
| Sound | Tim Simonec | Orchestrator |
| Sound | Dominik Hauser | Orchestrator |
| Sound | Peter Boyer | Orchestrator |
| Editing | Mo Henry | Negative Cutter |
| Art | Chris L. Spellman | Production Design |
| Art | Bob Kensinger | Set Decoration |
| Sound | Graeme Revell | Original Music Composer |
| Crew | Gary Hymes | Stunt Coordinator |
| Crew | Mike Smith | Stunt Coordinator |
| Production | Suzanne Smith Crowley | Casting |
| Sound | Jonathan Karp | Music Supervisor |
| Editing | Colin Patton | First Assistant Editor |
| Camera | Darren Michaels | Still Photographer |
| Directing | Ronit Ravich-Boss | Script Supervisor |
| Production | Tom Carson | Production Coordinator |
| Sound | David Giammarco | Sound Re-Recording Mixer |
| Sound | Michael O'Farrell | Sound Re-Recording Mixer |
| Sound | Cindy Marty | Sound Effects Editor |
| Sound | George H. Anderson | Supervising Sound Editor |
| Costume & Make-Up | Melissa Yonkey | Hair Department Head |
| Costume & Make-Up | Soo-Jin Yoon | Key Hair Stylist |
| Crew | J.J. Perry | Stunts |
| Sound | Christof Gebert | Production Sound Mixer |
| Sound | James Matheny | Dialogue Editor |
| Sound | Michael Haight | Dialogue Editor |
| Sound | Larry Kemp | Supervising ADR Editor |
| Sound | Kyle Rochlin | Foley Mixer |
| Sound | Vincent Guisetti | Foley Artist |
| Sound | Pamela Kahn | Foley Artist |
| Sound | Bruce Lacey | Foley Editor |
| Sound | Howard London | ADR Mixer |
| Sound | Jonathan Karp | Music Editor |
| Directing | Peter Dress | Second Second Assistant Director |
