Het avontuur begint met het verschijnen van Mewtwo, een genetisch gemanipuleerde Pokémon, gecreëerd uit het DNA van Mew, de zeldzaamste van alle Pokémon. Mewtwo is vastbesloten om zijn superioriteit te bewijzen en verleidt Ash, Pikachu en de anderen in een strijd, zoals er nog nooit is geweest: Mewtwo tegen Mew, superkloon tegen Pokémon. Het gaat hier om de ultieme confrontatie met de toekomst van de wereld als inzet.
Nee, helaas is Pokémon: de film - Mewtwo tegen Mew nog niet beschikbaar op Netflix in Nederland.
| Production | 吉川兆二 | Producer |
| Directing | 湯山邦彦 | Director |
| Writing | 首藤剛志 | Screenplay |
| Visual Effects | 志村泉 | Animation Director |
| Visual Effects | 一石小百合 | Character Designer |
| Art | 湯山邦彦 | Storyboard Artist |
| Visual Effects | 窪敏 | Key Animation |
| Visual Effects | 佐藤雄三 | Key Animation |
| Visual Effects | Yasuhide Maruyama | Key Animation |
| Visual Effects | 木村文代 | Key Animation |
| Visual Effects | Kaori Kunii | Key Animation |
| Visual Effects | Akiko Nakamura | Key Animation |
| Visual Effects | Katsuichi Nakayama | Key Animation |
| Visual Effects | Masao Nakata | Key Animation |
| Visual Effects | 野崎恒仲 | Key Animation |
| Visual Effects | 川口博史 | Key Animation |
| Visual Effects | Tadaaki Miyata | Key Animation |
| Visual Effects | Yoshihiro Nagamori | Key Animation |
| Visual Effects | 佐藤和巳 | Key Animation |
| Visual Effects | Junko Isaka | Key Animation |
| Visual Effects | 大杉宜弘 | Key Animation |
| Visual Effects | 斉藤英子 | Key Animation |
| Visual Effects | Satomi Kitahara | Key Animation |
| Visual Effects | 増尾昭一 | Key Animation |
| Visual Effects | 入好さとる | Key Animation |
| Visual Effects | Tomoko Takei | Key Animation |
| Visual Effects | Midori Nagaoka | Key Animation |
| Visual Effects | 高橋英吉 | Animation Director |
| Visual Effects | 中西麻美子 | Key Animation |
| Visual Effects | 柳田義明 | Animation Director |
| Visual Effects | Katsuyuki Tamura | Key Animation |
| Visual Effects | 関口雅浩 | Key Animation |
| Visual Effects | 藤森雅也 | Animation Director |
| Visual Effects | 加来哲郎 | Key Animation |
| Visual Effects | 向山祐治 | Key Animation |
| Visual Effects | 新岡浩美 | Key Animation |
| Visual Effects | Hideaki Maniwa | Key Animation |
| Visual Effects | 志村泉 | Key Animation |
| Visual Effects | Norihiro Matsubara | Animation Director |
| Visual Effects | 数井浩子 | Key Animation |
| Visual Effects | Shunya Yamada | Animation Director |
| Visual Effects | Yuriko Chiba | Key Animation |
| Visual Effects | Masami Takebuchi | Key Animation |
| Visual Effects | 諏訪昌夫 | Key Animation |
| Visual Effects | 千葉ゆみ | Key Animation |
| Visual Effects | 武田政次 | Key Animation |
| Visual Effects | 熊岡利治 | Key Animation |
| Visual Effects | Midori Yamakubo | Key Animation |
| Visual Effects | 毛利和昭 | Key Animation |
| Visual Effects | 岩根雅明 | Key Animation |
| Visual Effects | Masaru Fukumoto | Animation Director |
| Visual Effects | 藤森雅也 | Key Animation |
| Visual Effects | Koji Fukasawa | Key Animation |
| Visual Effects | 松本卓也 | Key Animation |
| Visual Effects | 森悦史 | Key Animation |
| Visual Effects | Nori Nakamura | Key Animation |
| Camera | 白井久男 | Director of Photography |
| Writing | 田尻智 | Original Story |
| Sound | Hirokazu Tanaka | Music |
| Sound | 宮崎慎二 | Music |
