Een paar maanden nadat Seth Brundle de dood vond door Veronica's geweer, baart zij zijn zoon, Martin. Seth's werkgever adopteert Martin, om zo zijn genen te kunnen gebruiken voor een superleger. Een paar jaar later is Martin volgroeid, ondanks dat hij pas vijf is, en de vlieg in hem begint wakker te worden. Met de hulp van zijn vriendin Beth probeert hij hulp te zoeken.
Nee, helaas is The Fly II nog niet beschikbaar op Netflix in Nederland.
| Directing | Chris Walas | Director |
| Writing | Jim Wheat | Screenplay |
| Production | Steven-Charles Jaffe | Producer |
| Camera | Robin Vidgeon | Director of Photography |
| Editing | Sean Barton | Editor |
| Writing | Mick Garris | Screenplay |
| Writing | Ken Wheat | Screenplay |
| Writing | Frank Darabont | Screenplay |
| Visual Effects | Chris Walas | Effects Supervisor |
| Production | Deborah Lucchesi | Casting |
| Costume & Make-Up | Christopher Ryan | Costume Design |
| Editing | John Watson | Assistant Editor |
| Art | Glen W. Pearson | Assistant Art Director |
| Visual Effects | Joseph Thomas | Animation |
| Crew | James H. Chow | Property Master |
| Sound | Patrick Dodd | ADR & Dubbing |
| Production | Tracey Jeffrey | Location Manager |
| Art | Rose Marie McSherry | Set Decoration |
| Sound | Ralph Wikke | Sound Effects Editor |
| Editing | Jay Ignaszewski | First Assistant Editor |
| Sound | Earl Ghaffari | Music Editor |
| Editing | Patrick Dodd | Dialogue Editor |
| Production | Michelle Allen | Casting |
| Editing | Michael Smith | First Assistant Editor |
| Art | Thom Wells | Construction Coordinator |
| Visual Effects | John T. Van Vliet | Animation |
| Camera | Joseph Lederer | Still Photographer |
| Costume & Make-Up | Sherry Linder-Gygli | Hairstylist |
| Sound | Danny Kopelson | Sound Re-Recording Mixer |
| Visual Effects | Katherine Kean | Animation |
| Lighting | Stephen Jackson | Gaffer |
| Sound | Jay Ignaszewski | Music Editor |
| Art | Michael S. Bolton | Production Design |
| Art | Sandy Cochrane | Art Direction |
| Lighting | Richard Buckmaster | Rigging Gaffer |
| Art | Avo Liva | Greensman |
| Sound | Leslie Shatz | Sound Designer |
| Directing | Jean Bereziuk | Script Supervisor |
| Sound | David Parker | Sound Re-Recording Mixer |
| Visual Effects | January Nordman | Animation |
| Costume & Make-Up | Jayne Dancose | Makeup Artist |
| Art | Steve Craine | Lead Painter |
| Camera | John Clothier | Steadicam Operator |
| Crew | John Wardlow | Stunt Coordinator |
| Crew | Steve Newman | Unit Publicist |
| Camera | Cyrus Block | Camera Operator |
| Directing | Peter D. Marshall | First Assistant Director |
| Costume & Make-Up | Jo-Anne Smith-Ojeil | Special Effects Makeup Artist |
| Costume & Make-Up | Sydney Silvert | Assistant Makeup Artist |
| Production | Gillian Richardson | Associate Producer |
| Writing | George Langelaan | Characters |
| Writing | Mick Garris | Story |
| Costume & Make-Up | Brenda Turner | Assistant Hairstylist |
| Costume & Make-Up | Dennis Pawlik | Special Effects Makeup Artist |
| Directing | Kenna Marshall-Pittman | Third Assistant Director |
| Costume & Make-Up | Stephan Dupuis | Special Effects Makeup Artist |
| Directing | Peter Talbot | Assistant Director Trainee |
| Directing | Richard Coleman | Second Assistant Director |
| Production | Mel Brooks | Producer |
| Production | Stuart Cornfeld | Executive Producer |
| Sound | Christopher Young | Original Music Composer |
