De berekenende en afstandelijke seriemoordenaar Henry Lee Lucas deelt een appartement met de wat simpele Otis. Wanneer Otis' jongere zus Becky komt logeren, lijkt zij tot Henry's gevoelige kant door te dringen. Maar Otis en Henry gaan ondertussen samen ook steeds vaker op pad, en dat blijft niet zonder gevolgen.
Nee, helaas is Henry: Portrait of a Serial Killer nog niet beschikbaar op Netflix in Nederland.
| Writing | Richard Fire | Screenplay |
| Production | John McNaughton | Producer |
| Production | Steven A. Jones | Producer |
| Writing | John McNaughton | Screenplay |
| Camera | Charlie Lieberman | Director of Photography |
| Editing | Elena Maganini | Editor |
| Directing | John McNaughton | Director |
| Sound | Robert McNaughton | Original Music Composer |
| Sound | Steven A. Jones | Original Music Composer |
| Sound | Ken Hale | Original Music Composer |
| Production | Lisa Dedmond | Producer |
| Costume & Make-Up | Patricia Hart | Costume Design |
| Art | Rick Paul | Art Direction |
| Sound | Cory Coken | Sound Editor |
| Crew | Michael J. Alonzi | Makeup Effects |
| Crew | Scott Whitehead | Makeup Effects |
| Production | Waleed B. Ali | Executive Producer |
| Directing | Andrew Bradburn | Second Assistant Director |
| Art | Rick Paul | Property Master |
| Costume & Make-Up | Berndt Rantscheff | Makeup Artist |
| Directing | Paul Chen | First Assistant Director |
| Art | Rick Paul | Set Dresser |
| Costume & Make-Up | Chuck Gatz | Hairstylist |
| Costume & Make-Up | Jeffery Lyle Segal | Special Effects Makeup Artist |
| Production | Lisa Dedmond | Production Manager |
| Crew | Steven A. Jones | Post Production Supervisor |
| Production | Malik B. Ali | Executive Producer |
| Production | Jeffery Lyle Segal | Casting |
| Art | Frank Coronado | Storyboard Artist |
| Crew | Herb Nordheimer | Makeup Effects |
| Camera | Brian Graham | Grip |
| Sound | Dan Haberkorn | Sound Effects |
| Art | David Le Boy | Title Designer |
| Sound | Jim Moore | Sound Re-Recording Assistant |
| Sound | Steven A. Jones | Music Director |
| Camera | Dave Buckley | Grip |
| Camera | Berndt Rantscheff | Still Photographer |
| Camera | Paul Petraitis | Still Photographer |
| Crew | Paul M. Lane | Stunts |
| Camera | Bradley Sellers | Assistant Camera |
| Production | Bradley Magon | Production Assistant |
| Sound | Thomas T. Yore | Sound Recordist |
| Sound | Steve Wilburn | Sound Re-Recording Assistant |
| Directing | Melanie Hecht | Script Supervisor |
| Camera | David Mahlman | Assistant Camera |
| Art | Steven A. Jones | Title Designer |
