Er is een geheime oorlog gaande waar de mensen niets van af weten: de eeuwige strijd tussen de honden en de katten. De katten zijn van plan een nieuw vaccin te vernietigen. Dit vaccin zal namelijk alle menselijke allergieën voor honden genezen.
Nee, helaas is Cats & Dogs nog niet beschikbaar op Netflix in Nederland.
| Directing | Lawrence Guterman | Director |
| Writing | Glenn Ficarra | Screenplay |
| Writing | John Requa | Screenplay |
| Production | Christopher DeFaria | Producer |
| Sound | John Debney | Original Music Composer |
| Camera | Julio Macat | Director of Photography |
| Editing | Rick Finney | Editor |
| Visual Effects | Eric Oliver | Animation |
| Writing | Bob Camp | Storyboard |
| Sound | Mark Mangini | Supervising Dialogue Editor |
| Crew | J.J. Makaro | Stunt Coordinator |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Production | Chris Bender | Executive Producer |
| Production | Warren Zide | Producer |
| Production | Andrew Lazar | Producer |
| Production | Craig Perry | Producer |
| Production | Bruce Berman | Executive Producer |
| Costume & Make-Up | Tish Monaghan | Costume Design |
| Art | James D. Bissell | Production Design |
| Production | J.C. Spink | Executive Producer |
| Editing | Michael A. Stevenson | Editor |
| Editing | Jason Tucker | First Assistant Editor |
| Visual Effects | John Slattery | Digital Compositor |
| Visual Effects | Craig Barron | Visual Effects Supervisor |
| Visual Effects | Tex Kadonaga | Modeling |
| Crew | Jim Dunn | Stunt Coordinator |
| Crew | Corry Glass | Stunts |
| Crew | David Jacox | Stunts |
| Crew | Boone Narr | Stunt Coordinator |
| Crew | Ken Kirzinger | Stunt Coordinator |
| Crew | Ron James | Stunts |
| Crew | David Mylrea | Stunts |
| Crew | Kristene Kenward | Stunts |
| Crew | Gerald Paetz | Stunt Driver |
| Crew | Jovan Nenadic | Stunts |
| Crew | Lori Stewart | Stunts |
| Crew | Fred Perron | Stunts |
| Crew | Greg Schlosser | Stunts |
| Crew | Brad Loree | Stunts |
| Crew | John Wardlow | Stunts |
| Crew | Rene Van Hullebush | Stunts |
| Lighting | Andrew W. Davidson | Gaffer |
