Nu George zoveel tijd doorbrengt met zijn nieuwe vriend Will, voelt Stuart zich eenzaam. Wanneer hij in zijn rode sportautootje naar huis rijdt, wordt hij opgeschrikt door een uit de lucht vallende vogel. Haar naam is Margalo, ze is gewond aan haar vleugel en ze wordt achtervolgd door een grote valk. Stuart neemt haar mee naar huis. Wanneer Margalo spoorloos verdwijnt, ontdekt Stuart dat ze door de Valk wordt bedreigd en dat hij haar gemene dingen laat doen. Met de hulp van de kat Snowbell, probeert hij Margalo te redden.
Ja! de film Stuart Little 2 is nu beschikbaar om te kijken op Netflix in Nederland.
| Sound | Alan Silvestri | Original Music Composer |
| Production | Douglas Wick | Producer |
| Editing | Priscilla Nedd-Friendly | Editor |
| Camera | Steven Poster | Director of Photography |
| Directing | Rob Minkoff | Director |
| Visual Effects | Angie Jones | Animation |
| Visual Effects | Craig R. Maras | Animation |
| Directing | Mark Vargo | Second Unit Director |
| Crew | Boone Narr | Stunt Coordinator |
| Costume & Make-Up | Mary Guerrero | Hairstylist |
| Art | Shepherd Frankel | Art Direction |
| Crew | Danny Aiello III | Stunt Coordinator |
| Visual Effects | Eric Armstrong | Animation Supervisor |
| Crew | Jay Redd | Digital Effects Supervisor |
| Visual Effects | Dan Foster | Visual Effects Producer |
| Crew | Mark Herman | Visual Effects Editor |
| Visual Effects | Michelle Murdocca | Visual Effects Producer |
| Sound | Donald Flick | Sound Designer |
| Visual Effects | Tony Bancroft | Animation Supervisor |
| Sound | David A. Whittaker | Supervising Sound Editor |
| Visual Effects | Bill Westenhofer | Visual Effects Supervisor |
| Art | Lisa K. Sessions | Set Decoration |
| Costume & Make-Up | Tammy Ashmore | Makeup Artist |
| Costume & Make-Up | Robert Hallowell II | Hair Supervisor |
| Production | Michelle Murdocca | Associate Producer |
| Crew | Christopher Sjoholm | Digital Effects Supervisor |
| Sound | Kenneth Karman | Music Editor |
| Crew | George Denes Suhayda | Visual Effects Art Director |
| Production | Rachel Shane | Associate Producer |
| Costume & Make-Up | Bonita DeHaven | Makeup Supervisor |
| Production | Lucy Fisher | Producer |
| Sound | Bonnie Greenberg | Music Supervisor |
| Art | Bill Brzeski | Production Design |
| Production | Francine Maisler | Casting |
| Production | Steve Waterman | Executive Producer |
| Production | Jeff Franklin | Executive Producer |
| Production | Jason Clark | Executive Producer |
| Costume & Make-Up | Mona May | Costume Design |
| Production | Gail Lyon | Executive Producer |
| Art | Thor Freudenthal | Conceptual Design |
| Production | Rob Minkoff | Executive Producer |
| Crew | Tony R. Medina | Propmaker |
| Crew | John Cenatiempo | Stunts |
| Writing | E.B. White | Characters |
| Writing | Bruce Joel Rubin | Story |
| Writing | Bruce Joel Rubin | Screenplay |
| Writing | Douglas Wick | Story |
| Visual Effects | Jerome Chen | Visual Effects Supervisor |
