Jack Morrison is een ambitieuze brandweerman die van groentje uitgroeit tot doorgewinterde professional. Zijn gevaarlijke en veeleisende baan vergt veel energie en gaat vaak ten koste van zijn vrouw en kinderen. Steun vindt hij bij zijn mentor en commandant Mike Kennedy en bij zijn tweede familie 'De Broeders van de Brandweerkazerne'. Maar als Jack tijdens een zware klus wordt ingesloten door een vlammenzee, wordt hem duidelijk waar het in het leven echt om draait; familie, waardigheid en moed. Terwijl zijn collega's van Ladder 49 alles doen om hem te redden, hangt Jacks leven aan een zijden draadje.
Nee, helaas is Ladder 49 nog niet beschikbaar op Netflix in Nederland.
| Production | Marty P. Ewing | Executive Producer |
| Editing | M. Scott Smith | Editor |
| Sound | William Ross | Original Music Composer |
| Writing | Lewis Colick | Screenplay |
| Camera | James L. Carter | Director of Photography |
| Production | Armyan Bernstein | Executive Producer |
| Editing | Bud S. Smith | Editor |
| Production | Casey Silver | Producer |
| Directing | Jay Russell | Director |
| Art | Michael Davis | Construction Coordinator |
| Crew | Peter Epstein | Stunts |
| Production | Leigh Simons | Line Producer |
| Production | Anson Downes | Associate Producer |
| Production | Nancy Foy | Casting |
| Production | Linda Favila | Associate Producer |
| Production | Manny Chavez | Associate Producer |
| Production | Chris Salvaterra | Co-Producer |
| Costume & Make-Up | Sherri Bramlett | Hairstylist |
| Art | Peter Oktavec | Painter |
| Costume & Make-Up | Matt Danon | Key Hair Stylist |
| Costume & Make-Up | Lisa Dietrich | Set Costumer |
| Crew | Gary Duncan | Picture Car Coordinator |
| Lighting | Jay Kemp | Rigging Gaffer |
| Sound | Aynee Osborn | First Assistant Sound Editor |
| Sound | Kirk Francis | Sound Mixer |
| Sound | Kelly Cabral | Supervising Sound Editor |
| Production | Kim Everett | Casting Associate |
| Art | Gregory Bolton | Art Direction |
| Production | Don Miller | Production Accountant |
| Sound | Bunny Andrews | Music Editor |
| Costume & Make-Up | Catharine Fletcher Incaprera | Costume Supervisor |
| Crew | Bryan Badman | Carpenter |
| Crew | Scott E. Corly | Driver |
| Camera | Andy Colvin | Camera Operator |
| Crew | Miller Drake | Visual Effects Editor |
| Art | Maggie Martin | Set Decoration |
| Art | Ted Lubonovich II | Construction Foreman |
| Crew | John A. Amicarella | Post Production Supervisor |
| Crew | Miguel Sánchez | Security |
| Directing | Deirdre Horgan | Script Supervisor |
| Production | Melissa Stanley Cohen | Production Coordinator |
| Sound | William L. Kaplan | Boom Operator |
| Art | Tiffany Zappulla | Set Decoration Buyer |
| Crew | Peter Damien | Propmaker |
| Production | Charles Thomas Baxter | Location Manager |
| Art | Kevin Constant | Art Direction |
| Art | Hugo Santiago | Assistant Art Director |
| Camera | Vidal Cohen | Grip |
| Costume & Make-Up | Erik Boring | Set Dressing Artist |
| Crew | Peter J. Silbermann | Unit Publicist |
| Lighting | Chris Henry | Electrician |
| Production | Nancy Rae Stone | Executive In Charge Of Production |
| Art | Tony Burrough | Production Design |
| Costume & Make-Up | Renee Ehrlich Kalfus | Costume Design |
| Art | Paul D. Kelly | Set Designer |
| Crew | G.A. Aguilar | Stunt Coordinator |
| Crew | Douglas A. Walk | Transportation Co-Captain |
| Sound | John Bissell | Music Supervisor |
| Crew | Don Austin | Stand In |
| Crew | Gerald Titus | Transportation Captain |
| Editing | Jeff Smithwick | Color Timer |
| Costume & Make-Up | David Atherton | Makeup Artist |
| Crew | Philippe Gallichet | Chef |
| Crew | Jessica Needleman | Post Production Assistant |
| Sound | Thomas O'Neil Younkman | Sound Designer |
| Crew | Michael Luckeroth | Transportation Coordinator |
| Production | Amy Herman | Unit Production Manager |
| Lighting | Newton TerMeer | Gaffer |
| Lighting | Austin Cross | Lighting Technician |
| Art | Mike Raybould | Greensman |
| Art | Caprice Ericson | Location Scout |
| Camera | Ron Phillips | Still Photographer |
| Crew | Roy Farfel | Stunts |
| Sound | Armin Steiner | Scoring Mixer |
| Sound | Paul Timothy Carden | Sound Editor |
| Art | Jane Burka | Art Department Coordinator |
| Camera | Ronald Hersey | Helicopter Camera |
| Crew | Peter Evangelatos | Craft Service |
| Crew | Larry Fioritto | Special Effects Coordinator |
| Crew | David 'Goldy' Goldsmith | Video Assist Operator |
| Production | Michele Giordano | Production Supervisor |
| Sound | Bruce Babcock | Orchestrator |
| Sound | Rickley W. Dumm | Sound Effects Editor |
| Visual Effects | Chris Flynn | Digital Compositors |
| Visual Effects | Collin Fowler | Visual Effects Coordinator |
| Visual Effects | Patrick Phillips | Visual Effects |
| Visual Effects | Darin McCormick-Millett | Visual Effects Producer |
| Visual Effects | Peter Donen | Visual Effects Supervisor |
| Art | Arthur Shippee | Property Master |
| Sound | Bill Meadows | Sound Recordist |
| Sound | Lauren Stephens | Supervising Sound Editor |
| Sound | Elizabeth Kenton | Dialogue Editor |
| Directing | Vincent Lascoumes | First Assistant Director |
| Directing | M. James Arnett | Second Unit Director |
| Crew | John Cenatiempo | Stunts |
| Crew | Jill Brown | Stunts |
| Costume & Make-Up | Stephanie Karangelen | Costume Coordinator |
| Sound | Peter Thomas | Location Sound Mixer |
| Costume & Make-Up | Deb Dalton | Costumer |
| Art | Eric Ladd | Title Designer |
| Sound | Edward Steidele | Foley Artist |
| Costume & Make-Up | Mara Majorowicz | Key Costumer |
| Directing | Julian Brain | Second Second Assistant Director |
| Costume & Make-Up | Terri Trupp | Assistant Makeup Artist |
| Art | Joseph Musso | Storyboard Artist |
| Sound | Gary Coppola | Foley Mixer |
| Sound | Doc Kane | ADR Mixer |
| Directing | Christophe Le Chanu | Second Assistant Director |
| Directing | Eric Richard Lasko | Additional Second Assistant Director |
| Camera | Alan Gitlin | Digital Imaging Technician |
| Editing | Jason Bretz | Assistant Editor |
| Crew | Bob Colletti | Stunt Double |
| Production | Judith Babcock | Post Production Coordinator |
| Production | Cassandra Quigel | Casting Assistant |
| Camera | John Hamilton | Camera Loader |
| Camera | Ed Nessen | Additional Second Assistant Camera |
| Editing | David Bernstein | Colorist |
| Crew | Robert L. Girard | Special Effects Technician |
| Camera | Alisa M. Colley | Second Assistant Camera |
| Production | Beth Dubber | Travel Coordinator |
| Production | Sandra Buttimer | Assistant Location Manager |
| Production | Whitney Green | Production Executive |
| Production | Barbara Harris | ADR Voice Casting |
| Production | Jessica Needleman | Location Assistant |
| Costume & Make-Up | Gail A. Fitzgibbons | Wardrobe Supervisor |
| Production | Anthea Strangis | Second Assistant Accountant |
| Lighting | Gary Kangrga | Key Rigging Grip |
| Production | Jennifer Madeloff | Assistant Production Coordinator |
| Crew | Ric San Nicholas | Pyrotechnician |
| Camera | Jonas Lagunoff | Best Boy Grip |
| Editing | Mary Beth Smith | Negative Cutter |
| Production | Laura Connors | Assistant Accountant |
| Sound | Natalie Baartz | Music Coordinator |
| Production | Gail Rose | First Assistant Accountant |
| Production | Matthew Barrabee | Production Assistant |
| Production | Nikki Taylor Roberts | Art Department Production Assistant |
| Production | Rob Mitchell | Controller |
| Production | Taffy Schweickhardt | Payroll Accountant |
| Crew | Mark Yant | Technical Advisor |
| Sound | William Ross | Conductor |
