Ondanks dat Eddie ontslagen wordt, stuurt zijn baas hem en zijn familie toch op verlof. Dit in de hoop dat Eddie hem geen proces aandoet omdat hij gebeten werd door een aap in het laboratorium. Wanneer de familie echter ongewild op een tropisch eiland belandt, kan Eddie zichzelf eindelijk bewijzen tegenover zijn familie als een échte man die voor zijn familie zorgt.
Nee, helaas is Christmas Vacation 2: Cousin Eddie's Island Adventure nog niet beschikbaar op Netflix in Nederland.
| Sound | Nathan Furst | Original Music Composer |
| Editing | Joel Goodman | Editor |
| Art | Rodger Maus | Production Design |
| Camera | Rohn Schmidt | Director of Photography |
| Production | Elliot Friedgen | Producer |
| Production | Matty Simmons | Executive Producer |
| Writing | Matty Simmons | Writer |
| Directing | Nick Marck | Director |
| Crew | Buck McDancer | Stunt Coordinator |
| Crew | Danny Epper | Stunts |
| Crew | Ian Quinn | Stunts |
| Crew | Kristopher Medina | Stunts |
| Crew | Jeffrey McDancer | Stunts |
| Crew | Steven Lambert | Stunts |
| Production | Kim Orchen | Casting |
| Production | Robert Grand | Unit Production Manager |
| Directing | Jerram A. Swartz | First Assistant Director |
| Directing | Ruth A. Redfern | Second Assistant Director |
| Crew | Desireé J. Cadena | Post Production Supervisor |
| Art | Karen Agresti | Set Decoration |
| Camera | Billy Gierhart | Camera Operator |
| Camera | Billy Gierhart | Steadicam Operator |
| Camera | Bud Kremp | "B" Camera Operator |
| Camera | Wally Sweeterman | First Assistant "A" Camera |
| Camera | Michael Otis Ropert | First Assistant "B" Camera |
| Camera | Jason Jensen | Second Assistant "A" Camera |
| Camera | Ray Dier | Second Assistant "B" Camera |
| Sound | Jonathon 'Earl' Stein | Sound Mixer |
| Sound | Brent Brewington | Boom Operator |
| Sound | Michael E. Lawshe | Supervising Sound Editor |
| Sound | Gregory M. Gerlich | Supervising Sound Editor |
| Editing | Tony Kadell | Assistant Editor |
| Production | Ellen Rauch | Executive In Charge Of Production |
| Production | Carol Kravetz | Production Coordinator |
| Production | Dan Laz Lazarovits | Assistant Production Coordinator |
| Production | Deborah Laub | Location Manager |
| Production | Grant Hansen | Assistant Location Manager |
| Directing | Steve Gehrke | Script Supervisor |
| Sound | Todd Grace | Sound Re-Recording Mixer |
| Sound | Rudy Pi | Sound Re-Recording Mixer |
| Directing | Cara McCastlain Fisher | Second Second Assistant Director |
| Production | Diana Jaher | Casting Associate |
| Lighting | Derrick Kolus | Chief Lighting Technician |
| Lighting | Scott Fieldsteel | Electrician |
| Lighting | Paul Vakay | Best Boy Electric |
| Lighting | Brent R. Morgan | Electrician |
| Lighting | Robert Donn | Electrician |
| Lighting | Matthew Hawkins | Electrician |
| Lighting | Michael Kennedy | Electrician |
| Lighting | Curtis King | Electrician |
| Lighting | Scott Toland | Electrician |
| Lighting | Michael Evans | Electrician |
| Lighting | Chris Hults | Electrician |
| Lighting | Jeffrey Kilgore | Electrician |
| Lighting | Laura Stewart | Electrician |
| Lighting | Scott Williman | Electrician |
| Camera | Kevin Ball | Key Grip |
| Camera | Jason Rupe | Best Boy Grip |
| Camera | Sandy Bloom | Best Boy Grip |
| Camera | Michael Flaningam | Dolly Grip |
| Camera | Lister Coleman | Grip |
| Camera | Jeremy Graham | Grip |
| Camera | Paul Reyes | Grip |
| Camera | William Tricarico | Grip |
| Camera | Jamie Lind | Grip |
| Camera | Matt Minke | Grip |
| Camera | Jeffrey Tomhave | Grip |
| Art | Rich Hobaica | Property Master |
| Costume & Make-Up | Lisa Rocco | Makeup Artist |
| Costume & Make-Up | Danny Valencia | Hairstylist |
| Costume & Make-Up | Cheryl Markowitz | Assistant Makeup Artist |
| Costume & Make-Up | Patricia Gundlach | Assistant Hairstylist |
| Costume & Make-Up | Fay Kelly | Assistant Hairstylist |
| Costume & Make-Up | Sara Markowitz | Costume Designer |
| Costume & Make-Up | Nava R. Sadan | Costume Supervisor |
| Costume & Make-Up | Suzanne Cranfield | Set Costumer |
| Costume & Make-Up | Patia Prouty | Set Costumer |
| Costume & Make-Up | Erin Lenk | Set Costumer |
| Costume & Make-Up | Susan Strubel | Set Costumer |
| Crew | John Gray | Special Effects Coordinator |
| Crew | John Ziegler | Special Effects |
| Crew | Nick Karas | Special Effects |
| Crew | Roland Hathaway | Special Effects |
| Crew | Derrell Roberts | Special Effects |
| Crew | Don Gray | Special Effects |
| Crew | Jeffrey Knott | Special Effects |
| Crew | Brandon K. McLaughlin | Special Effects |
| Crew | Arthur G. Schlosser | Special Effects |
| Art | Cate Bangs | Set Designer |
| Art | Peggy Casey | Set Decoration |
| Art | Peggy Casey | Set Decoration Buyer |
| Art | Curtis R. Allen | Set Dresser |
| Art | Paul Detlefson | Set Dresser |
| Art | Luigi Mugavero | Set Dresser |
| Art | Benton E. Tedlie | Set Dresser |
| Art | Brian D. McStotts | Set Dresser |
| Art | Nick Raymond | Set Dresser |
| Art | John F. Barton | Set Dresser |
| Art | Chris Hayes | Set Dresser |
| Art | E. Shepherd Stevenson | Set Dresser |
| Art | Tyler Kettenburg | Set Dresser |
| Art | Howard Miller | Set Dresser |
| Art | Le'Von Webb | Set Dresser |
| Art | Mark Vitale | Construction Coordinator |
| Production | Mara Lopez | Executive In Charge Of Post Production |
| Sound | Helle Huxley | Music Director |
| Sound | Gregory M. Gerlich | ADR Supervisor |
| Sound | Chris McGeary | Music Editor |
| Sound | Timothy A. Cleveland | Sound Effects Editor |
| Sound | Paul J. Diller | Sound Effects Editor |
| Sound | Stu Calderon | Foley Editor |
| Sound | Karyn Foster | ADR Editor |
| Sound | Jessica Dickson | Dialogue Editor |
| Sound | Karyn Foster | Dialogue Editor |
| Sound | Lisa W. Grove | First Assistant Sound Editor |
| Sound | Casey J. Crabtree | Foley Artist |
| Sound | Mike Crabtree | Foley Artist |
| Sound | Tom Ruff | Foley Artist |
| Sound | Beth Hopper | Foley Artist |
| Sound | Eric Gotthelf | ADR Mixer |
| Sound | Troy Porter | ADR Mixer |
| Sound | Al Gomez | Foley Mixer |
| Production | Mickie McGowan | ADR Voice Casting |
| Production | Sherry Lynn | ADR Voice Casting |
| Editing | Joe Finley | Color Timer |
| Visual Effects | David Takemura | Visual Effects Supervisor |
| Directing | John Stephens | Second Unit Director |
| Directing | Louis Race | Second Unit First Assistant Director |
| Camera | Michael McEveety | First Assistant Camera |
| Camera | Matt Credle | Second Assistant Camera |
| Camera | Ernie Reed | "B" Camera Operator |
