Clark Griswold en zijn familie besluiten een tripje te maken naar Las Vegas. Hij verliest onmiddellijk zijn geld met gokken, aangespoord door de dealer. Zijn vrouw raakt in vervoering van de casino-zanger Wayne Newton en mag zelfs met hem op het podium zingen. In de tussentijd begeven hun kinderen zich in allerlei problematische situaties en wanneer ze hun maffe neef Eddie, die in de buurt woont, opzoeken zijn de gevolgen helemaal niet meer te overzien.
Nee, helaas is Vegas Vacation nog niet beschikbaar op Netflix in Nederland.
| Editing | Seth Flaum | Editor |
| Sound | Joel McNeely | Original Music Composer |
| Writing | Elisa Bell | Screenplay |
| Production | Matty Simmons | Executive Producer |
| Production | Susan Ekins | Executive Producer |
| Directing | Stephen Kessler | Director |
| Production | Jerry Weintraub | Producer |
| Camera | William A. Fraker | Director of Photography |
| Costume & Make-Up | Carole Brown-James | Costume Design |
| Art | Chris L. Spellman | Set Decoration |
| Costume & Make-Up | Peggy Semtob | Key Hair Stylist |
| Art | David L. Snyder | Production Design |
| Costume & Make-Up | Marvin G. Westmore | Key Makeup Artist |
| Art | Thomas Valentine | Art Direction |
| Costume & Make-Up | Joyce Westmore | Makeup Artist |
| Crew | Allan Graf | Stunt Coordinator |
| Crew | Marian Green | Stunts |
| Crew | Casey O'Neill | Stunts |
| Crew | Lisa McCullough | Stunts |
| Crew | Jeannie Epper | Stunts |
| Crew | Gene LeBell | Stunts |
| Writing | Bob Ducsay | Screenstory |
| Crew | Lynn Salvatori | Stunts |
| Writing | Elisa Bell | Story |
| Production | R.J. Louis | Co-Producer |
| Directing | Jack Ziga | First Assistant Director |
| Directing | Allan Graf | Second Unit Director |
| Directing | Robin R. Oliver | Second Assistant Director |
| Costume & Make-Up | Stephen Robinette | Hairstylist |
| Crew | Brian Avery | Stunts |
| Crew | Michael Adams | Stunts |
| Crew | Steve Blalock | Stunts |
| Crew | Perry Barndt | Stunts |
| Crew | Phil Chong | Stunts |
| Crew | Buff Brady | Stunts |
| Crew | Jamie A. Keyser | Stunts |
| Crew | Ken Blazer | Stunts |
| Crew | Michelle Burkette | Stunts |
| Crew | Paul Borne | Stunts |
| Crew | Michael Owen | Stunts |
| Crew | Debi Parker | Stunts |
| Crew | Dorenda Moore | Stunts |
| Crew | Dana Reed | Stunts |
| Crew | John Robotham | Stunts |
| Crew | John S. Platt | Stunts |
| Crew | Dennis Scott | Stunts |
| Crew | Kaye Wade | Stunts |
| Crew | Anthony G. Schmidt | Stunts |
| Crew | George P. Wilbur | Stunts |
| Crew | Lee Whittaker | Stunts |
| Camera | David E. Diano | Camera Operator |
| Lighting | Doug Pentek | Chief Lighting Technician |
| Camera | Chris Haarhoff | Camera Operator |
| Crew | Barry Lather | Choreographer |
