Clark Griswold en zijn familie besluiten een tripje te maken naar Las Vegas. Hij verliest onmiddellijk zijn geld met gokken, aangespoord door de dealer. Zijn vrouw raakt in vervoering van de casino-zanger Wayne Newton en mag zelfs met hem op het podium zingen. In de tussentijd begeven hun kinderen zich in allerlei problematische situaties en wanneer ze hun maffe neef Eddie, die in de buurt woont, opzoeken zijn de gevolgen helemaal niet meer te overzien.
Nee, helaas is Vegas Vacation nog niet beschikbaar op Netflix in Nederland.
| Directing | Stephen Kessler | Director |
| Writing | Elisa Bell | Screenplay |
| Production | Susan Ekins | Executive Producer |
| Production | Matty Simmons | Executive Producer |
| Production | Jerry Weintraub | Producer |
| Sound | Joel McNeely | Original Music Composer |
| Camera | William A. Fraker | Director of Photography |
| Editing | Seth Flaum | Editor |
| Art | David L. Snyder | Production Design |
| Art | Thomas Valentine | Art Direction |
| Art | Chris L. Spellman | Set Decoration |
| Costume & Make-Up | Carole Brown-James | Costume Design |
| Costume & Make-Up | Marvin G. Westmore | Key Makeup Artist |
| Costume & Make-Up | Peggy Semtob | Key Hair Stylist |
| Costume & Make-Up | Joyce Westmore | Makeup Artist |
| Crew | Allan Graf | Stunt Coordinator |
| Crew | Marian Green | Stunts |
| Crew | Casey O'Neill | Stunts |
| Crew | Lisa McCullough | Stunts |
| Crew | Jeannie Epper | Stunts |
| Crew | Gene LeBell | Stunts |
| Writing | Bob Ducsay | Screenstory |
| Crew | Lynn Salvatori | Stunts |
| Writing | Elisa Bell | Story |
| Production | R.J. Louis | Co-Producer |
| Directing | Jack Ziga | First Assistant Director |
| Directing | Allan Graf | Second Unit Director |
| Directing | Robin R. Oliver | Second Assistant Director |
| Costume & Make-Up | Stephen Robinette | Hairstylist |
| Crew | Brian Avery | Stunts |
| Crew | Michael Adams | Stunts |
| Crew | Steve Blalock | Stunts |
| Crew | Perry Barndt | Stunts |
| Crew | Phil Chong | Stunts |
| Crew | Buff Brady | Stunts |
| Crew | Jamie A. Keyser | Stunts |
| Crew | Ken Blazer | Stunts |
| Crew | Michelle Burkette | Stunts |
| Crew | Paul Borne | Stunts |
| Crew | Michael Owen | Stunts |
| Crew | Debi Parker | Stunts |
| Crew | Dorenda Moore | Stunts |
| Crew | Dana Reed | Stunts |
| Crew | John Robotham | Stunts |
| Crew | John S. Platt | Stunts |
| Crew | Dennis Scott | Stunts |
| Crew | Kaye Wade | Stunts |
| Crew | Anthony G. Schmidt | Stunts |
| Crew | George P. Wilbur | Stunts |
| Crew | Lee Whittaker | Stunts |
| Camera | David E. Diano | Camera Operator |
| Lighting | Doug Pentek | Chief Lighting Technician |
| Camera | Chris Haarhoff | Camera Operator |
| Crew | Barry Lather | Choreographer |
