Cheech en Chong ontmoeten elkaar op een verlaten snelweg in de buurt van California. In hun zoektocht naar drugs worden ze per ongeluk vervoerd naar Mexico. Om terug te komen in Amerika gaan ze accoord met een voorstel om een Truck terug de grens over te rijden, niet wetend wat er achterin zit. Onderweg nemen ze ook nog eens een paar lifters mee...
Nee, helaas is Up in Smoke nog niet beschikbaar op Netflix in Nederland.
| Production | John Beug | Associate Producer |
| Writing | Cheech Marin | Writer |
| Art | Leon Ericksen | Art Direction |
| Production | Lou Adler | Producer |
| Editing | Lou Lombardo | Supervising Editor |
| Writing | Tommy Chong | Writer |
| Directing | Lou Adler | Director |
| Editing | Scott Conrad | Editor |
| Camera | Gene Polito | Director of Photography |
| Production | Lou Lombardo | Producer |
| Directing | Mike Moder | Assistant Director |
| Camera | Bernie Schwartz | Dolly Grip |
| Art | Sidney H. Greenwood | Property Master |
| Sound | Patrick Mitchell | Sound Mixer |
| Lighting | Lon Massey III | Gaffer |
| Costume & Make-Up | Ernest Misko | Wardrobe Supervisor |
| Camera | Jack Willoughby | Additional Photography |
| Art | Jerry Kobold | Assistant Property Master |
| Camera | Gaylin P. Schultz | Key Grip |
| Costume & Make-Up | Wes Dawn | Makeup Artist |
| Editing | Lori Jane Coleman | Assistant Editor |
| Sound | John Wilkinson | Sound Re-Recording Mixer |
| Directing | William S. Beasley | Second Assistant Director |
| Production | Mike Moder | Unit Production Manager |
| Production | Monica Lauer | Casting |
| Camera | Sidney Ray Baldwin | Still Photographer |
| Costume & Make-Up | Lola 'Skip' McNalley | Hairstylist |
| Editing | Barry B. Leirer | Assistant Editor |
| Directing | Pamela Alch | Script Supervisor |
