Cheech en Chong ontmoeten elkaar op een verlaten snelweg in de buurt van California. In hun zoektocht naar drugs worden ze per ongeluk vervoerd naar Mexico. Om terug te komen in Amerika gaan ze accoord met een voorstel om een Truck terug de grens over te rijden, niet wetend wat er achterin zit. Onderweg nemen ze ook nog eens een paar lifters mee...
Nee, helaas is Up in Smoke nog niet beschikbaar op Netflix in Nederland.
| Production | John Beug | Associate Producer |
| Camera | Gene Polito | Director of Photography |
| Editing | Scott Conrad | Editor |
| Writing | Cheech Marin | Writer |
| Production | Lou Lombardo | Producer |
| Editing | Lou Lombardo | Supervising Editor |
| Directing | Lou Adler | Director |
| Art | Leon Ericksen | Art Direction |
| Writing | Tommy Chong | Writer |
| Production | Lou Adler | Producer |
| Costume & Make-Up | Wes Dawn | Makeup Artist |
| Sound | Patrick Mitchell | Sound Mixer |
| Art | Jerry Kobold | Assistant Property Master |
| Costume & Make-Up | Ernest Misko | Wardrobe Supervisor |
| Costume & Make-Up | Lola 'Skip' McNalley | Hairstylist |
| Editing | Barry B. Leirer | Assistant Editor |
| Camera | Sidney Ray Baldwin | Still Photographer |
| Directing | Pamela Alch | Script Supervisor |
| Production | Monica Lauer | Casting |
| Directing | Mike Moder | Assistant Director |
| Camera | Bernie Schwartz | Dolly Grip |
| Editing | Lori Jane Coleman | Assistant Editor |
| Sound | John Wilkinson | Sound Re-Recording Mixer |
| Directing | William S. Beasley | Second Assistant Director |
| Camera | Gaylin P. Schultz | Key Grip |
| Camera | Jack Willoughby | Additional Photography |
| Lighting | Lon Massey III | Gaffer |
| Art | Sidney H. Greenwood | Property Master |
| Production | Mike Moder | Unit Production Manager |
