FBI-agent Malcolm Turner moet weer eens undercover gaan en neemt opnieuw de gedaante aan van 'Big Momma'. Ditmaal moet er iemand in de gaten gehouden worden en Big Momma neemt hiervoor een baan aan als huishoudster bij de verdachte. Het blijkt dat de verdachte echter ook drie nogal vervelende kinderen heeft waar Big Momma het mee aan de stok krijgt.
Nee, helaas is Big Momma's House 2 nog niet beschikbaar op Netflix in Nederland.
| Production | Jeff Kwatinetz | Executive Producer |
| Production | Arnon Milchan | Executive Producer |
| Sound | George S. Clinton | Original Music Composer |
| Directing | John Whitesell | Director |
| Production | David T. Friendly | Producer |
| Production | Martin Lawrence | Executive Producer |
| Production | Michael Green | Producer |
| Editing | Priscilla Nedd-Friendly | Editor |
| Camera | Mark Irwin | Director of Photography |
| Writing | Don Rhymer | Screenplay |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Dane Farwell | Stunts |
| Crew | Al Goto | Stunts |
| Crew | Chick Bernhard | Stunt Double |
| Writing | Darryl Quarles | Characters |
| Crew | Mark Norby | Stunts |
| Production | Nancy Foy | Casting |
| Production | Sean Lampkin | Executive Assistant |
| Costume & Make-Up | Debrae Little | Costume Design |
| Art | Craig Stearns | Production Design |
| Art | Ellen Totleben | Set Decoration |
| Art | Charlie Daboub | Art Direction |
| Crew | Charles Croughwell | Stunt Coordinator |
| Directing | Charles Croughwell | Second Unit Director |
| Crew | Gary J. Wayton | Stunts |
| Crew | Denney Pierce | Stunts |
| Production | Mark Fincannon | Casting |
| Production | Lisa Mae Fincannon | Casting |
| Art | Clara Blyth | Runner Art Department |
