FBI-agent Malcolm Turner moet weer eens undercover gaan en neemt opnieuw de gedaante aan van 'Big Momma'. Ditmaal moet er iemand in de gaten gehouden worden en Big Momma neemt hiervoor een baan aan als huishoudster bij de verdachte. Het blijkt dat de verdachte echter ook drie nogal vervelende kinderen heeft waar Big Momma het mee aan de stok krijgt.
Nee, helaas is Big Momma's House 2 nog niet beschikbaar op Netflix in Nederland.
| Production | David T. Friendly | Producer |
| Production | Jeff Kwatinetz | Executive Producer |
| Camera | Mark Irwin | Director of Photography |
| Production | Michael Green | Producer |
| Directing | John Whitesell | Director |
| Writing | Don Rhymer | Screenplay |
| Sound | George S. Clinton | Original Music Composer |
| Production | Arnon Milchan | Executive Producer |
| Editing | Priscilla Nedd-Friendly | Editor |
| Production | Martin Lawrence | Executive Producer |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Dane Farwell | Stunts |
| Crew | Al Goto | Stunts |
| Crew | Chick Bernhard | Stunt Double |
| Writing | Darryl Quarles | Characters |
| Crew | Mark Norby | Stunts |
| Production | Nancy Foy | Casting |
| Production | Sean Lampkin | Executive Assistant |
| Art | Ellen Totleben | Set Decoration |
| Art | Craig Stearns | Production Design |
| Costume & Make-Up | Debrae Little | Costume Design |
| Art | Charlie Daboub | Art Direction |
| Crew | Charles Croughwell | Stunt Coordinator |
| Directing | Charles Croughwell | Second Unit Director |
| Crew | Gary J. Wayton | Stunts |
| Crew | Denney Pierce | Stunts |
| Production | Lisa Mae Fincannon | Casting |
| Production | Mark Fincannon | Casting |
| Art | Clara Blyth | Runner Art Department |
