In de herfst van 1953 trekt de ambitieuze lerares Katherine Watson naar het Wellesley College, één van de meest prestigieuze meisjesscholen van de Verenigde Staten. Ze zal er kunstgeschiedenis gaan doceren. De aanpassing aan haar nieuwe omgeving verloopt echter moeizaam. Haar liefde voor moderne kunst en haar uitgesproken mening over de rol van de vrouw in de samenleving worden allesbehalve gewaardeerd door haar conservatieve collega's.
Nee, helaas is Mona Lisa Smile nog niet beschikbaar op Netflix in Nederland.
| Directing | Mike Newell | Director |
| Writing | Lawrence Konner | Screenplay |
| Writing | Mark Rosenthal | Screenplay |
| Production | Elaine Goldsmith-Thomas | Producer |
| Production | Paul Schiff | Producer |
| Production | Deborah Schindler | Producer |
| Production | Joe Roth | Executive Producer |
| Camera | Anastas N. Michos | Director of Photography |
| Editing | Mick Audsley | Editor |
| Costume & Make-Up | Frances Kolar | Key Makeup Artist |
| Sound | Peter Burgis | Foley Artist |
| Sound | Andie Derrick | Foley Artist |
| Sound | Tim Cavagin | Sound Re-Recording Mixer |
| Sound | Colette D. Dahanne | ADR Mixer |
| Sound | Colin Cooper | ADR Mixer |
| Sound | Peter Gleaves | ADR Mixer |
| Sound | Daniel Laurie | ADR Editor |
| Sound | Derek Trigg | Foley Editor |
| Sound | Steve Single | Sound Re-Recording Mixer |
| Costume & Make-Up | Carla Antonino | Makeup Artist |
| Costume & Make-Up | Kristen Barry | Hairstylist |
| Costume & Make-Up | Robert Chiu | Hairstylist |
| Costume & Make-Up | Bonnie Clevering | Hairstylist |
| Costume & Make-Up | Richard Dean | Makeup Artist |
| Costume & Make-Up | Paula Dion | Hairstylist |
| Costume & Make-Up | Joseph Farulla | Makeup Artist |
| Costume & Make-Up | Donna Marie Fischetto | Hairstylist |
| Costume & Make-Up | Michelle Johnson | Hairstylist |
| Costume & Make-Up | Heidi Kulow | Makeup Artist |
| Costume & Make-Up | Christine Leiter | Makeup Artist |
| Costume & Make-Up | Brenda McNally | Hairstylist |
| Costume & Make-Up | John Quaglia | Hairstylist |
| Costume & Make-Up | Joe Rossi | Makeup Artist |
| Costume & Make-Up | Kerrie R. Plant | Makeup Artist |
| Sound | Rachel Portman | Original Music Composer |
| Production | Susie Farris | Casting |
| Production | Ellen Chenoweth | Casting |
| Art | Jane Musky | Production Design |
| Art | Patricia Woodbridge | Art Direction |
| Costume & Make-Up | Michael Dennison | Costume Design |
| Costume & Make-Up | Margot Boccia | Makeup Department Head |
| Directing | Lisa Katcher | Script Supervisor |
| Production | Richard Baratta | Co-Producer |
| Art | Susan Bode Tyson | Set Decoration |
| Art | Chris Nickerson | Set Decoration |
| Visual Effects | Randall Balsmeyer | Visual Effects Supervisor |
| Directing | Paul Schiff | Second Unit Director |
| Directing | Eddie Micallef | Second Assistant Director |
| Sound | Mark Auguste | Supervising Sound Editor |
| Art | Ray Fisher | Leadman |
| Directing | Joseph P. Reidy | First Assistant Director |
| Art | Joseph S. Alfieri | Construction Coordinator |
| Sound | Daniel Laurie | Dialogue Editor |
| Visual Effects | Drew Jones | Visual Effects Production Manager |
