In de herfst van 1953 trekt de ambitieuze lerares Katherine Watson naar het Wellesley College, één van de meest prestigieuze meisjesscholen van de Verenigde Staten. Ze zal er kunstgeschiedenis gaan doceren. De aanpassing aan haar nieuwe omgeving verloopt echter moeizaam. Haar liefde voor moderne kunst en haar uitgesproken mening over de rol van de vrouw in de samenleving worden allesbehalve gewaardeerd door haar conservatieve collega's.
Nee, helaas is Mona Lisa Smile nog niet beschikbaar op Netflix in Nederland.
| Directing | Mike Newell | Director |
| Writing | Lawrence Konner | Screenplay |
| Production | Deborah Schindler | Producer |
| Production | Elaine Goldsmith-Thomas | Producer |
| Writing | Mark Rosenthal | Screenplay |
| Editing | Mick Audsley | Editor |
| Production | Paul Schiff | Producer |
| Production | Joe Roth | Executive Producer |
| Camera | Anastas N. Michos | Director of Photography |
| Costume & Make-Up | Frances Kolar | Key Makeup Artist |
| Sound | Peter Gleaves | ADR Mixer |
| Costume & Make-Up | Heidi Kulow | Makeup Artist |
| Sound | Colette D. Dahanne | ADR Mixer |
| Costume & Make-Up | Kristen Barry | Hairstylist |
| Sound | Daniel Laurie | ADR Editor |
| Costume & Make-Up | Joseph Farulla | Makeup Artist |
| Sound | Tim Cavagin | Sound Re-Recording Mixer |
| Sound | Colin Cooper | ADR Mixer |
| Costume & Make-Up | Carla Antonino | Makeup Artist |
| Costume & Make-Up | Michelle Johnson | Hairstylist |
| Sound | Steve Single | Sound Re-Recording Mixer |
| Costume & Make-Up | Kerrie R. Plant | Makeup Artist |
| Costume & Make-Up | Joe Rossi | Makeup Artist |
| Costume & Make-Up | Bonnie Clevering | Hairstylist |
| Costume & Make-Up | Paula Dion | Hairstylist |
| Costume & Make-Up | Brenda McNally | Hairstylist |
| Costume & Make-Up | Christine Leiter | Makeup Artist |
| Sound | Peter Burgis | Foley Artist |
| Sound | Derek Trigg | Foley Editor |
| Costume & Make-Up | Richard Dean | Makeup Artist |
| Costume & Make-Up | Donna Marie Fischetto | Hairstylist |
| Sound | Andie Derrick | Foley Artist |
| Costume & Make-Up | Robert Chiu | Hairstylist |
| Costume & Make-Up | John Quaglia | Hairstylist |
| Art | Patricia Woodbridge | Art Direction |
| Art | Susan Bode Tyson | Set Decoration |
| Directing | Lisa Katcher | Script Supervisor |
| Costume & Make-Up | Michael Dennison | Costume Design |
| Production | Richard Baratta | Co-Producer |
| Visual Effects | Randall Balsmeyer | Visual Effects Supervisor |
| Art | Jane Musky | Production Design |
| Sound | Rachel Portman | Original Music Composer |
| Costume & Make-Up | Margot Boccia | Makeup Department Head |
| Production | Ellen Chenoweth | Casting |
| Art | Chris Nickerson | Set Decoration |
| Production | Susie Farris | Casting |
| Directing | Paul Schiff | Second Unit Director |
| Sound | Mark Auguste | Supervising Sound Editor |
| Directing | Eddie Micallef | Second Assistant Director |
| Art | Ray Fisher | Leadman |
| Directing | Joseph P. Reidy | First Assistant Director |
| Art | Joseph S. Alfieri | Construction Coordinator |
| Sound | Daniel Laurie | Dialogue Editor |
