Het voormalige schurken team van Megamind, The Doom Syndicate, is teruggekeerd. Onze nieuw gekroonde blauwe held moet nu de kwade schijn ophouden totdat hij zijn vrienden (Roxanne, Ol' Chum en Keiko) kan verzamelen om te voorkomen dat zijn voormalige kwaadaardige teamgenoten Metro City naar de maan lanceren.
Nee, helaas is Megamind vs. the Doom Syndicate nog niet beschikbaar op Netflix in Nederland.
| Production | J.D. Ryznar | Co-Executive Producer |
| Writing | Alan Schoolcraft | Writer |
| Production | Brent Simons | Executive Producer |
| Production | Alan Schoolcraft | Executive Producer |
| Writing | Brent Simons | Writer |
| Directing | Eric Fogel | Director |
| Sound | Alex Seaver | Main Title Theme Composer |
| Production | Katie Galvan | Casting |
| Art | Renee Howerton | Storyboard Artist |
| Art | Hadas Rosen | Storyboard Artist |
| Art | Jason Horychun | Storyboard Artist |
| Art | Solomon Fong | Storyboard Artist |
| Production | Ania O'Hare | Casting |
| Art | Jessica Bulinski | Art Direction |
| Visual Effects | Jeff Solway | Character Designer |
| Production | Gregg Goldin | Executive In Charge Of Production |
| Art | Dennis Crawford | Storyboard Artist |
| Art | Karen Poon | Art Direction |
| Production | Eric Fogel | Executive Producer |
| Production | Nora Lewis-Borbely | Line Producer |
| Art | Alejandra Wiechers | Storyboard Artist |
| Production | Michael Moragne | Line Producer |
| Production | Sarah Wall | Line Producer |
| Art | Nicola Kwit | Background Designer |
| Visual Effects | Allyssa Clemente | Color Designer |
| Sound | Adam McGhie | Foley Artist |
| Art | Rod Filbrandt | Prop Designer |
| Production | David Wiebe | Executive In Charge Of Production |
| Art | Amy Fielder | Background Designer |
| Sound | Kirk Furniss | Sound Editor |
| Visual Effects | Margot Senchyna | Matte Painter |
| Art | Stephanie Foley | Prop Designer |
| Art | Mariel Abella | Prop Designer |
| Sound | Marcel Duperreault | Sound Re-Recording Mixer |
| Art | Gareth Sharples | Background Designer |
| Visual Effects | Stacey Chomiak | Color Designer |
| Production | Peter Cacioppo | Executive In Charge Of Production |
| Sound | Todd Araki | Sound Editor |
| Sound | Jason Fredrickson | Sound Editor |
| Sound | Matthew Janszen | Original Music Composer |
| Sound | Bryan Winslow | Original Music Composer |
| Sound | Lauren Vogel | Music Supervisor |
| Sound | Vivian Aguiar-Buff | Music Supervisor |
