Frank Detorri heeft maar een hobby: eten. Alles wat eetbaar is en vooral snacks kan hij niet weerstaan. Frank is lui en heeft een hekel aan beweging. Als hij op zijn werk als verzorger in de dierentuin een hardgekookt ei op de grond laat vallen, bedenkt hij zich geen moment. Hij pakt het op, opent zijn mond en eet het vieze ei op. Vanaf dat moment is er paniek in het ongezonde lichaam van Frank. Osmosis Joses, een jonge witte bloedcel en politieagent, probeert de orde te handhaven in Frank City. Samen met de pijnstiller Drix gaat Osmosis de strijd aanbinden tegen het virus Thrax om Frank en de inwoners van Frank City te behoeden voor een fatale afloop.
Nee, helaas is Osmosis Jones nog niet beschikbaar op Netflix in Nederland.
| Production | Bobby Farrelly | Producer |
| Editing | Lois Freeman-Fox | Editor |
| Directing | Bobby Farrelly | Director |
| Sound | Randy Edelman | Original Music Composer |
| Production | Zak Penn | Producer |
| Editing | Stephen Schaffer | Editor |
| Writing | Marc Hyman | Screenplay |
| Editing | Sam Seig | Editor |
| Production | Peter Farrelly | Producer |
| Camera | Mark Irwin | Director of Photography |
| Production | Bradley Thomas | Producer |
| Directing | Peter Farrelly | Director |
| Visual Effects | Adam Beck | Animation |
| Crew | Jeannine Berger | Post Production Supervisor |
| Visual Effects | Paul Dutton | Animation |
| Directing | Audrey Stedman | Layout |
| Writing | Bob Camp | Storyboard |
| Directing | Karen Hamrock | Layout |
| Visual Effects | Eddie Rosas | Animation |
| Directing | Jennifer Yuan | Layout |
| Directing | Bill Perkins | Layout |
| Visual Effects | Earl A. Hibbert | Visual Effects |
| Visual Effects | Hani D. El-Masri | Visual Development |
| Writing | Steve Fonti | Storyboard |
| Crew | John Bermudes | Special Effects |
| Crew | William 'Billy Jack' Jakielaszek | Special Effects Coordinator |
| Art | Arlan Jay Vetter | Art Direction |
| Visual Effects | Chris Aguirre | Visual Development |
| Writing | Mark Andrews | Storyboard |
| Art | Carol Koch | Sculptor |
| Visual Effects | Kevin Johnson | Visual Development |
| Production | Marc S. Fischer | Co-Producer |
| Writing | Barry Caldwell | Storyboard |
| Visual Effects | Ruben Chavez | Visual Development |
| Art | Katherine C. Concepcion | Art Department Manager |
| Writing | Daan Jippes | Storyboard |
| Production | Aaron Parry | Associate Producer |
| Visual Effects | Darek Gogol | Visual Development |
| Crew | John Harajovic | Special Effects |
| Visual Effects | Ricardo F. Delgado | Visual Development |
| Crew | Leon Delaney | Stunt Coordinator |
| Production | John Walker | Associate Producer |
| Visual Effects | Jeff Etter | Visual Development |
| Visual Effects | Craig R. Maras | Animation |
| Visual Effects | Randy Sanchez | Animation |
| Directing | James P. Alles | Layout |
| Visual Effects | John Williamson | Animation |
| Visual Effects | Joe Giampapa | Animation |
| Visual Effects | Sam Chou | Animation |
| Visual Effects | Shane Prigmore | Animation |
| Visual Effects | Fred Cline | Visual Development |
| Costume & Make-Up | Brenda McNally | Hair Department Head |
| Directing | Hal Olofsson | First Assistant Director |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Visual Effects | Ian Mah | Visual Effects Supervisor |
| Crew | Darlie Brewster | Supervising Animator |
| Visual Effects | Steven Burch | Special Effects Supervisor |
| Costume & Make-Up | Joe Rossi | Makeup Department Head |
| Sound | Randy Thom | Sound Designer |
| Visual Effects | Stephan Franck | Lead Animator |
| Sound | Ken Ross | Music Supervisor |
| Art | Scott Jacobson | Set Decoration |
| Production | Rick Montgomery | Casting |
| Production | Dennis Edwards | Producer |
| Crew | Alan J. Hagge | Systems Administrators & Support |
| Directing | Louis Gonzales | Layout |
| Art | Moroni Taylor | Storyboard Artist |
