Frank Detorri heeft maar een hobby: eten. Alles wat eetbaar is en vooral snacks kan hij niet weerstaan. Frank is lui en heeft een hekel aan beweging. Als hij op zijn werk als verzorger in de dierentuin een hardgekookt ei op de grond laat vallen, bedenkt hij zich geen moment. Hij pakt het op, opent zijn mond en eet het vieze ei op. Vanaf dat moment is er paniek in het ongezonde lichaam van Frank. Osmosis Joses, een jonge witte bloedcel en politieagent, probeert de orde te handhaven in Frank City. Samen met de pijnstiller Drix gaat Osmosis de strijd aanbinden tegen het virus Thrax om Frank en de inwoners van Frank City te behoeden voor een fatale afloop.
Nee, helaas is Osmosis Jones nog niet beschikbaar op Netflix in Nederland.
| Directing | Bobby Farrelly | Director |
| Writing | Marc Hyman | Screenplay |
| Production | Bobby Farrelly | Producer |
| Production | Peter Farrelly | Producer |
| Production | Zak Penn | Producer |
| Production | Bradley Thomas | Producer |
| Sound | Randy Edelman | Original Music Composer |
| Camera | Mark Irwin | Director of Photography |
| Editing | Lois Freeman-Fox | Editor |
| Editing | Stephen Schaffer | Editor |
| Editing | Sam Seig | Editor |
| Directing | Peter Farrelly | Director |
| Visual Effects | Adam Beck | Animation |
| Visual Effects | Paul Dutton | Animation |
| Crew | Jeannine Berger | Post Production Supervisor |
| Directing | Audrey Stedman | Layout |
| Directing | Karen Hamrock | Layout |
| Writing | Bob Camp | Storyboard |
| Visual Effects | Eddie Rosas | Animation |
| Directing | Bill Perkins | Layout |
| Directing | Jennifer Yuan | Layout |
| Visual Effects | Earl A. Hibbert | Visual Effects |
| Production | Marc S. Fischer | Co-Producer |
| Production | Aaron Parry | Associate Producer |
| Production | John Walker | Associate Producer |
| Art | Arlan Jay Vetter | Art Direction |
| Visual Effects | Chris Aguirre | Visual Development |
| Writing | Mark Andrews | Storyboard |
| Writing | Barry Caldwell | Storyboard |
| Visual Effects | Ruben Chavez | Visual Development |
| Art | Katherine C. Concepcion | Art Department Manager |
| Visual Effects | Ricardo F. Delgado | Visual Development |
| Visual Effects | Hani D. El-Masri | Visual Development |
| Visual Effects | Jeff Etter | Visual Development |
| Writing | Steve Fonti | Storyboard |
| Visual Effects | Darek Gogol | Visual Development |
| Writing | Daan Jippes | Storyboard |
| Visual Effects | Kevin Johnson | Visual Development |
| Crew | Leon Delaney | Stunt Coordinator |
| Crew | John Bermudes | Special Effects |
| Crew | John Harajovic | Special Effects |
| Crew | William 'Billy Jack' Jakielaszek | Special Effects Coordinator |
| Art | Carol Koch | Sculptor |
| Visual Effects | Craig R. Maras | Animation |
| Visual Effects | Randy Sanchez | Animation |
| Directing | James P. Alles | Layout |
| Visual Effects | John Williamson | Animation |
| Visual Effects | Joe Giampapa | Animation |
| Visual Effects | Sam Chou | Animation |
| Visual Effects | Shane Prigmore | Animation |
| Visual Effects | Fred Cline | Visual Development |
| Visual Effects | Stephan Franck | Lead Animator |
| Visual Effects | Ian Mah | Visual Effects Supervisor |
| Crew | Darlie Brewster | Supervising Animator |
| Production | Rick Montgomery | Casting |
| Visual Effects | Steven Burch | Special Effects Supervisor |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Art | Scott Jacobson | Set Decoration |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Costume & Make-Up | Brenda McNally | Hair Department Head |
| Costume & Make-Up | Joe Rossi | Makeup Department Head |
| Directing | Hal Olofsson | First Assistant Director |
| Sound | Ken Ross | Music Supervisor |
| Sound | Randy Thom | Sound Designer |
| Production | Dennis Edwards | Producer |
| Crew | Alan J. Hagge | Systems Administrators & Support |
| Directing | Louis Gonzales | Layout |
| Art | Moroni Taylor | Storyboard Artist |
