In 1939 vernietigt de jonge professor Bruttenholm Erzsebet Ondrushko, een vampier die in het bloed baadde van onschuldige vrouwen om jong te blijven nadat ze haar ziel had verkocht aan de Koningin van de Heksen, de godin Hecate. Jaren later hoort het BPRD van een behekst huis in New York.
Nee, helaas is Hellboy Animated: Blood and Iron nog niet beschikbaar op Netflix in Nederland.
| Crew | Tad Stones | Additional Writing |
| Production | Scott Greenberg | Executive Producer |
| Writing | Mike Mignola | Characters |
| Directing | Tad Stones | Director |
| Production | Lawrence Gordon | Executive Producer |
| Directing | Victor Cook | Director |
| Production | Sidney Clifton | Executive Producer |
| Writing | Kevin Hopps | Screenplay |
| Writing | Guillermo del Toro | Creative Producer |
| Sound | Christopher Drake | Original Music Composer |
| Writing | Mike Mignola | Comic Book |
| Production | Stephanie Elliott | Producer |
| Production | Stephen R. Brown | Executive Producer |
| Production | Mike Mignola | Consulting Producer |
| Production | Mike Richardson | Executive Producer |
| Production | Tad Stones | Supervising Producer |
| Writing | Mike Mignola | Story |
| Production | Lloyd Levin | Executive Producer |
| Writing | Tad Stones | Story |
| Production | Michael Wolf | Executive Producer |
| Production | Morris Berger | Executive Producer |
| Production | John W. Hyde | Executive Producer |
| Editing | Matt Steinauer | Editor |
| Production | Scott Hemming | Executive Producer |
