Twee Neanderthalers en de bijbel! Zed en Oh zijn primitieve holbewoners die uit hun dorp worden verbannen en besluiten een epische reis door de oudheid te maken. De ene is een stuntelige jager, de andere een zachtaardige vruchtenplukker. Dit tweetal geraakt onverwacht verwikkeld in een paar van de belangrijkste bijbelse gebeurtenissen.
| Production | Judd Apatow | Producer |
| Writing | Gene Stupnitsky | Screenplay |
| Writing | Lee Eisenberg | Screenplay |
| Production | Rodney Rothman | Executive Producer |
| Writing | Harold Ramis | Screenplay |
| Production | Clayton Townsend | Producer |
| Directing | Harold Ramis | Director |
| Crew | Matt Leonard | Stunts |
| Crew | Tom Elliott | Stunts |
| Art | Dorree Cooper | Set Decoration |
| Production | Harold Ramis | Producer |
| Art | Richard Fojo | Art Direction |
| Sound | George H. Anderson | Supervising Sound Editor |
| Sound | Gary C. Bourgeois | Sound Re-Recording Mixer |
| Sound | James Matheny | Dialogue Editor |
| Camera | Monty Rowan | Camera Operator |
| Camera | Chris Squires | Steadicam Operator |
| Production | Tara Duncil | Extras Casting |
| Art | Jefferson Sage | Production Design |
| Sound | Alison Fisher | ADR Editor |
| Sound | Susan Kurtz | ADR Editor |
| Sound | Ulrika Akander | ADR Editor |
| Editing | Steve Welch | Editor |
| Production | Barrett J. Leigh | Production Supervisor |
| Camera | Suzanne Hanover | Still Photographer |
| Camera | Jerry G. Callaway | Second Unit Director of Photography |
| Sound | Pamela Kahn | Foley Artist |
| Sound | Larry Kemp | Dialogue Editor |
| Production | Jeanne McCarthy | Casting |
| Sound | Joe Schiff | Foley Supervisor |
| Directing | Anne Rapp | Script Supervisor |
| Sound | Michael T. Ryan | Music Editor |
| Editing | Craig Herring | Editor |
| Production | Laurel A. Ward | Co-Producer |
| Production | Andrew Epstein | Associate Producer |
| Sound | Theodore Shapiro | Original Music Composer |
| Costume & Make-Up | Debra McGuire | Costume Design |
| Sound | Bill W. Benton | Sound Re-Recording Mixer |
| Sound | Sally Boldt | Music Editor |
| Camera | Chris Squires | Camera Operator |
| Camera | Alar Kivilo | Director of Photography |
| Art | Dwight Benjamin-Creel | Property Master |
| Sound | Thomas S. Drescher | Music Editor |
| Production | Clayton Townsend | Unit Production Manager |
| Production | Brinkley A. Maginnis | Extras Casting |
| Sound | Howard London | ADR Mixer |
| Sound | Tammy Fearing | Supervising ADR Editor |
| Directing | E.J. Foerster | Second Unit Director |
| Camera | Charles Libin | Second Unit Director of Photography |
| Sound | Cindy Marty | Sound Effects Editor |
| Sound | Vincent Guisetti | Foley Artist |
| Sound | Kyle Rochlin | Foley Mixer |
| Sound | Steve C. Aaron | Production Sound Mixer |
