Twee Neanderthalers en de bijbel! Zed en Oh zijn primitieve holbewoners die uit hun dorp worden verbannen en besluiten een epische reis door de oudheid te maken. De ene is een stuntelige jager, de andere een zachtaardige vruchtenplukker. Dit tweetal geraakt onverwacht verwikkeld in een paar van de belangrijkste bijbelse gebeurtenissen.
| Production | Clayton Townsend | Producer |
| Production | Judd Apatow | Producer |
| Writing | Harold Ramis | Screenplay |
| Writing | Gene Stupnitsky | Screenplay |
| Directing | Harold Ramis | Director |
| Writing | Lee Eisenberg | Screenplay |
| Production | Rodney Rothman | Executive Producer |
| Crew | Matt Leonard | Stunts |
| Crew | Tom Elliott | Stunts |
| Camera | Suzanne Hanover | Still Photographer |
| Camera | Monty Rowan | Camera Operator |
| Camera | Alar Kivilo | Director of Photography |
| Costume & Make-Up | Debra McGuire | Costume Design |
| Sound | Sally Boldt | Music Editor |
| Art | Dwight Benjamin-Creel | Property Master |
| Sound | Michael T. Ryan | Music Editor |
| Sound | Joe Schiff | Foley Supervisor |
| Sound | Thomas S. Drescher | Music Editor |
| Sound | Bill W. Benton | Sound Re-Recording Mixer |
| Production | Jeanne McCarthy | Casting |
| Sound | Susan Kurtz | ADR Editor |
| Camera | Chris Squires | Steadicam Operator |
| Camera | Chris Squires | Camera Operator |
| Editing | Craig Herring | Editor |
| Editing | Steve Welch | Editor |
| Production | Barrett J. Leigh | Production Supervisor |
| Sound | Larry Kemp | Dialogue Editor |
| Production | Harold Ramis | Producer |
| Production | Clayton Townsend | Unit Production Manager |
| Sound | Gary C. Bourgeois | Sound Re-Recording Mixer |
| Art | Jefferson Sage | Production Design |
| Art | Dorree Cooper | Set Decoration |
| Production | Laurel A. Ward | Co-Producer |
| Sound | Theodore Shapiro | Original Music Composer |
| Art | Richard Fojo | Art Direction |
| Directing | Anne Rapp | Script Supervisor |
| Sound | Ulrika Akander | ADR Editor |
| Production | Andrew Epstein | Associate Producer |
| Sound | George H. Anderson | Supervising Sound Editor |
| Sound | James Matheny | Dialogue Editor |
| Sound | Alison Fisher | ADR Editor |
| Sound | Vincent Guisetti | Foley Artist |
| Production | Tara Duncil | Extras Casting |
| Sound | Tammy Fearing | Supervising ADR Editor |
| Camera | Jerry G. Callaway | Second Unit Director of Photography |
| Camera | Charles Libin | Second Unit Director of Photography |
| Sound | Cindy Marty | Sound Effects Editor |
| Directing | E.J. Foerster | Second Unit Director |
| Sound | Kyle Rochlin | Foley Mixer |
| Sound | Steve C. Aaron | Production Sound Mixer |
| Sound | Pamela Kahn | Foley Artist |
| Production | Brinkley A. Maginnis | Extras Casting |
| Sound | Howard London | ADR Mixer |
| Crew | Carrick O'Quinn | Stunts |
