Carl en Molly Peterson zijn een pas getrouwd stelletje met een nieuw leven, nieuw huisje en pril geluk. Wanneer echter Carl's beste vriend Randy Dupree ontslagen wordt en in de goot belandt, nodigt Carl hem uit een tijdje bij hen te komen wonen. Dupree heeft het echter iets te goed naar zijn zin en Carl heeft het al moeilijk genoeg om de verantwoordelijke echtgenoot uit te hangen. Dan blijkt Dupree ook nog eens veel te goede maatjes te worden met Molly en haar vader..
Nee, helaas is You, Me and Dupree nog niet beschikbaar op Netflix in Nederland.
| Directing | Anthony Russo | Director |
| Production | Deborah Aquila | Casting |
| Sound | Theodore Shapiro | Original Music Composer |
| Art | Barbara Munch | Set Decoration |
| Production | Aaron Kaplan | Executive Producer |
| Production | Owen Wilson | Producer |
| Camera | Charles Minsky | Director of Photography |
| Editing | Peter B. Ellis | Editor |
| Editing | Debra Neil-Fisher | Editor |
| Directing | Joe Russo | Director |
| Costume & Make-Up | Karen Patch | Costume Design |
| Production | Scott Stuber | Producer |
| Production | Sean Perrone | Executive Producer |
| Writing | Michael LeSieur | Screenplay |
| Art | Barry Robison | Production Design |
| Production | Michael Fottrell | Executive Producer |
| Costume & Make-Up | Denise Dellavalle | Key Makeup Artist |
| Art | Chris Samp | Standby Painter |
| Costume & Make-Up | Medusah | Hair Department Head |
| Directing | Jennifer Carno | Script Coordinator |
| Costume & Make-Up | Kimberly Greene | Makeup Department Head |
| Art | Josh Lusby | Set Designer |
| Costume & Make-Up | Paula Hong | Hairstylist |
| Art | Paul Detlefson | Set Dresser |
| Costume & Make-Up | Elaine Perlmann | Assistant Costume Designer |
| Costume & Make-Up | Vickie Mynes | Key Hair Stylist |
| Art | Libby Morris | Set Decoration Buyer |
| Art | Bob Skemp | Greensman |
| Sound | Bob Beher | Foley Supervisor |
| Art | Rodolfo Damaggio | Production Illustrator |
| Sound | Roy Seeger | First Assistant Sound Editor |
| Lighting | James Keys | Rigging Gaffer |
| Visual Effects | Fumi Mashimo | Animation Supervisor |
| Costume & Make-Up | Hasmig Karaciosian | Seamstress |
| Sound | Carl Fischer | Boom Operator |
| Production | Catherine S. McComb | Production Supervisor |
| Crew | Jimmy N. Roberts | Stunt Coordinator |
| Art | Palma Bellardoni | Art Department Coordinator |
| Lighting | Jose F. Barrios | Rigging Grip |
| Sound | Andrew Spencer Dawson | Sound Editor |
| Crew | Jason Leib | Post Production Supervisor |
| Directing | Liliana M. Molina | Script Supervisor |
| Camera | Brian T. Pitts | Additional Camera |
| Crew | Anthony Woods | Set Medic |
| Costume & Make-Up | Amy Jo Hoppenfeld | Key Costumer |
| Art | Patricio M. Farrell | Assistant Art Director |
| Lighting | Ronald R. Koch Jr. | Lighting Technician |
| Crew | Marco Baccicalupi | Driver |
| Art | Greg Sanger | Leadman |
| Sound | Randall Poster | Music Supervisor |
| Camera | Sal Alvarez | Camera Loader |
| Art | Joey Genitempo | Set Painter |
| Crew | Ron Bolanowski | Special Effects Coordinator |
| Directing | Bob Roe | First Assistant Director |
| Editing | Ryan Helsley | Digital Intermediate |
| Camera | Mario Cisneros | Grip |
| Art | Bruce DiValerio | Construction Coordinator |
| Editing | Michael Eaves | Digital Color Timer |
| Art | Tommy Tomlinson | Property Master |
| Sound | Tony Blondal | Orchestrator |
| Sound | Thom Brennan | Foley Editor |
| Sound | Shawn Murphy | Scoring Mixer |
| Visual Effects | Andrew Tucker | 3D Artist |
| Crew | Cliff Fleming | Aerial Coordinator |
| Crew | Lesley Aletter | Utility Stunts |
| Sound | Benjamin Beardwood | Dialogue Editor |
| Production | Michael Fottrell | Unit Production Manager |
| Art | Fermin Davalos | Location Scout |
| Production | Jennifer L. Smith | Casting Associate |
| Sound | Philip Rogers | ADR Recordist |
| Sound | Jack Snyder | Sound Recordist |
| Editing | Sean Thompson | Additional Editor |
| Crew | Michael Rayle | Cableman |
| Art | Douglas J. Stewart | Textile Artist |
| Sound | Andrew Silver | Music Editor |
| Crew | Valerie Johnson | Set Production Assistant |
| Costume & Make-Up | Hilary Niederer | Costumer |
| Directing | Bernie Bonner Axelrod | Second Second Assistant Director |
| Directing | Adam Davidson | Second Unit Director |
| Production | Curtis Collins | Location Manager |
| Camera | Tommy Klines | First Assistant "A" Camera |
| Sound | Petur Hliddal | Sound Mixer |
| Art | Lance Ashton Slaton | Storyboard Artist |
| Visual Effects | Thad Beier | Visual Effects Supervisor |
| Sound | George Doering | Musician |
| Crew | Fred Teague | Transportation Captain |
| Crew | Ken Sale | Transportation Co-Captain |
| Production | Carlo Pratto | Post Production Accountant |
| Editing | Sam Seig | First Assistant Editor |
| Crew | Jesse Olivares | Video Assist Operator |
| Sound | Steven D. Williams | Supervising Sound Editor |
| Lighting | Danny Ault | Electrician |
| Sound | Andrea Horta | ADR Editor |
| Camera | Eric Budlong | Dolly Grip |
| Crew | Robert Castro | Stand In |
| Crew | Maxine Abarbara | Studio Teacher |
| Camera | Michael C. Price | Key Grip |
| Visual Effects | Melissa Brockman | Visual Effects Producer |
| Art | Jason Sweers | Graphic Designer |
| Sound | David Betancourt | Foley Recordist |
| Sound | Bruce Tanis | Sound Effects Editor |
| Costume & Make-Up | Dominic Gherardi | Tailor |
| Production | Alyssa Evans | Production Coordinator |
| Costume & Make-Up | Josh Ian Elliott | On Set Dresser |
| Costume & Make-Up | Lisa D. Quercioli | Set Costumer |
| Production | Patti Hawn | Publicist |
| Visual Effects | Collin Fowler | Visual Effects Coordinator |
| Crew | Steve Burnes | Propmaker |
| Crew | Dayne Ahuna | Craft Service |
| Crew | Victor Lozano | Marine Coordinator |
| Production | Donna Glasser-Hancock | Production Accountant |
| Crew | Jim Dunbar | Thanks |
| Lighting | Michelle LeDoux | Best Boy Electric |
| Sound | Jeff Gomillion | ADR Mixer |
| Camera | David E. Diano | "B" Camera Operator |
| Camera | Dale White | Second Assistant "A" Camera |
| Production | Caitlin McKenna | ADR Voice Casting |
| Crew | John A. Brubaker | Transportation Coordinator |
| Production | Alexandra Ward | Art Department Production Assistant |
| Production | Michele LaBrucherie | Key Set Production Assistant |
| Production | Mark Kurzweil | Second Assistant Accountant |
| Camera | Melissa Moseley | Still Photographer |
| Production | Erin Toner | Casting Assistant |
| Lighting | Jeff Murrell | Chief Lighting Technician |
| Art | Carolyn Lassek | Assistant Property Master |
| Editing | Mary Beth Smith | Negative Cutter |
| Production | Tammy L. Smith | Extras Casting |
| Camera | P. Scott Sakamoto | Camera Operator |
| Art | Catherine Leyba | Set Decorating Coordinator |
| Camera | Landon Ruddel | Best Boy Grip |
| Camera | Louie DeMarco | First Assistant "B" Camera |
| Sound | Dawn Fintor | Foley Artist |
| Lighting | Steve Reinhardt | Assistant Chief Lighting Technician |
| Production | Amy Denning Winfrey | Payroll Accountant |
| Costume & Make-Up | Charlene Amateau | Costume Supervisor |
| Production | Kirby Adams | First Assistant Accountant |
| Camera | Scott Whitbread | Second Assistant "B" Camera |
| Camera | Marcos O. Lopez | Second Assistant Camera |
| Sound | Bruce Babcock | Conductor |
| Editing | Mark Sachen | Colorist |
| Production | Adam Courier | Production Assistant |
| Crew | James A. Lundin | Base Camp Operator |
| Visual Effects | Chris Ryan | CG Artist |
| Sound | Stephen Coleman | Music Programmer |
| Production | Carrie Oyer | Assistant Production Coordinator |
| Production | Mary Parent | Producer |
| Art | Kevin Constant | Supervising Art Director |
| Art | Paul Sonski | Art Direction |
| Art | David Christopher Campbell | Construction Foreman |
| Crew | Erik Rondell | Stunts |
| Crew | Tanoai Reed | Stunts |
| Crew | Dick Ziker | Stunts |
| Production | Tricia Wood | Casting |
| Art | Dean Wolcott | Set Designer |
| Crew | Helena Barrett | Stunts |
| Costume & Make-Up | Valli O'Reilly | Makeup Artist |
| Costume & Make-Up | Kathryn Blondell | Hairstylist |
| Costume & Make-Up | Leslie Fuller | Makeup Artist |
