De tieners Fred, Velma, Daphne en Shaggy worden beschuldigd van een grap en geschorst van Coolsville High. En hoewel ze elkaar niet kennen en hun karakters ver uiteenlopen, besluiten de vier tieners hun naam te zuiveren en samen te werken om het mysterie op te lossen. En hierbij werkt het viertal samen met de pratende detective-hond Scooby Doo.
Nee, helaas is Scooby-Doo! The Mystery Begins nog niet beschikbaar op Netflix in Nederland.
| Writing | Steven Altiere | Writer |
| Writing | Daniel Altiere | Writer |
| Directing | Brian Levant | Director |
| Crew | Owen Walstrom | Stunts |
| Editing | Eric E. Osmond | Editor |
| Production | Brian Levant | Producer |
| Production | Brian J. Gilbert | Producer |
| Sound | David Newman | Original Music Composer |
| Camera | Jan Kiesser | Director of Photography |
| Art | Brentan Harron | Production Design |
| Costume & Make-Up | Kate Main | Costume Design |
| Production | Stuart Aikins | Casting |
| Visual Effects | Peter V. Ware | Visual Effects Producer |
| Production | Chris Foss | Line Producer |
| Production | Harriet Greenspan | Casting |
| Production | Sean Cossey | Casting |
| Directing | Josy Capkun | Second Assistant Director |
| Costume & Make-Up | April Boyes | Key Makeup Artist |
| Art | Roger Busque | Construction Foreman |
| Camera | Karl Herrmann | "B" Camera Operator |
| Camera | Adriene Wyse | Second Assistant "B" Camera |
| Camera | Ed Araquel | Still Photographer |
| Production | Karen Pelrine | Assistant Production Coordinator |
| Camera | John Kuchera | Key Grip |
| Sound | Lars Ekstrom | Sound Mixer |
| Sound | Ian Tarasoff | Utility Sound |
| Directing | Carl Mason | First Assistant Director |
| Art | Tyler Bishop Harron | Art Direction |
| Camera | Carrie Wilson | Second Assistant "A" Camera |
| Sound | Roderick Matte | Boom Operator |
| Production | Chris Foss | Unit Production Manager |
| Camera | Junichi Hosoi | "A" Camera Operator |
| Camera | Stephen J. McKnight | First Assistant "B" Camera |
| Costume & Make-Up | Joel Echallier | Makeup Effects Designer |
| Camera | Paul Arnel | Best Boy Grip |
| Crew | Darren Marcoux | Special Effects Coordinator |
| Art | Victoria Söderholm | Set Decoration |
| Crew | Eric Lemay | Special Effects Coordinator |
| Camera | Kieran Humphries | First Assistant "A" Camera |
| Directing | Karin Behrenz | Third Assistant Director |
| Art | Dean McQuillen | Construction Coordinator |
| Production | Ken Brooker | Location Manager |
| Art | Valentine Pavuls | Property Master |
| Crew | James Kozier | Special Effects |
| Production | Michele MacInnes | Production Office Coordinator |
| Production | Melyssa Rose | Assistant Production Coordinator |
| Costume & Make-Up | Danna Rutherford | Key Hair Stylist |
| Lighting | Derrick Garland | Rigging Grip |
| Production | Paul Russell | Assistant Location Manager |
| Art | David Manske | Set Dresser |
| Lighting | Timothy Hedgecock | Rigging Gaffer |
| Camera | David Kershaw | Dolly Grip |
| Crew | Ron Kozier | Special Effects |
| Crew | Sean P. Aislabie | Craft Service |
| Costume & Make-Up | Allison Chretien | Costumer |
| Lighting | Rory Soderman | Assistant Chief Lighting Technician |
| Art | Dylan Dowd | Greensman |
| Crew | Bob Dennett | Transportation Coordinator |
| Crew | Jan Kikumoto | Post Production Supervisor |
| Art | D. Martin Myatt | Props |
| Crew | Steve Woodley | Animal Wrangler |
| Costume & Make-Up | Moira Fentum | Costumer |
| Lighting | Darren McLean | Chief Lighting Technician |
| Crew | Darcy Woodley | Animal Wrangler |
| Production | Natasha Tony | Extras Casting |
| Crew | Dave Byerley | Transportation Captain |
| Directing | Jules Stewart | Script Supervisor |
| Costume & Make-Up | Paulette Nelson | Assistant Costume Designer |
| Camera | Sylvia Pranaitis | Dolly Grip |
| Art | Mark McQuillen | Construction Foreman |
| Production | Jane Mason | Production Accountant |
| Art | Laura Schneider | Assistant Property Master |
| Editing | Travis Dultz | First Assistant Editor |
| Sound | Kelly Vandever | Sound Re-Recording Mixer |
| Sound | Bryon Speller | Dialogue Editor |
| Sound | Alexander Pugh | Sound Effects Editor |
| Crew | Wilt Henderson | Visual Effects Editor |
| Visual Effects | Mark A.Z. Dippé | Visual Effects Supervisor |
| Visual Effects | Park Min-su | Visual Effects Supervisor |
| Sound | Mark A. Rozett | Sound Re-Recording Mixer |
| Sound | Steven Utt | Assistant Sound Editor |
| Sound | Brian S.M. Wroth | Dialogue Editor |
| Sound | Steven Avila | Sound Effects Editor |
| Sound | Peter D. Lago | Sound Effects Editor |
| Sound | Ben Whitver | ADR Mixer |
| Sound | Sean Madsen | Assistant Sound Editor |
| Sound | Jason Shaffer | Sound Effects Editor |
| Sound | Trip Brock | Supervising Sound Editor |
| Sound | Peter D. Lago | Sound Designer |
| Sound | Doug Latislaw | ADR Mixer |
| Sound | Steven Avila | Sound Designer |
| Sound | Caleb Easter | Foley Editor |
| Sound | Kyle Tilbury | Assistant Sound Editor |
| Editing | Sue Gates | Colorist |
| Sound | Zac Anderson | Foley Editor |
| Sound | Greg Mauer | Foley Mixer |
| Sound | Rick Owens | Foley Artist |
| Crew | Chad Sayn | Stunts |
| Crew | Hugo Steele | Stunts |
