De tieners Fred, Velma, Daphne en Shaggy worden beschuldigd van een grap en geschorst van Coolsville High. En hoewel ze elkaar niet kennen en hun karakters ver uiteenlopen, besluiten de vier tieners hun naam te zuiveren en samen te werken om het mysterie op te lossen. En hierbij werkt het viertal samen met de pratende detective-hond Scooby Doo.
Nee, helaas is Scooby-Doo! The Mystery Begins nog niet beschikbaar op Netflix in Nederland.
| Directing | Brian Levant | Director |
| Writing | Steven Altiere | Writer |
| Writing | Daniel Altiere | Writer |
| Crew | Owen Walstrom | Stunts |
| Production | Brian J. Gilbert | Producer |
| Sound | David Newman | Original Music Composer |
| Camera | Jan Kiesser | Director of Photography |
| Editing | Eric E. Osmond | Editor |
| Production | Brian Levant | Producer |
| Art | Brentan Harron | Production Design |
| Costume & Make-Up | Kate Main | Costume Design |
| Production | Harriet Greenspan | Casting |
| Production | Chris Foss | Line Producer |
| Sound | Lars Ekstrom | Sound Mixer |
| Camera | Ed Araquel | Still Photographer |
| Costume & Make-Up | Moira Fentum | Costumer |
| Art | D. Martin Myatt | Props |
| Production | Karen Pelrine | Assistant Production Coordinator |
| Art | Valentine Pavuls | Property Master |
| Production | Chris Foss | Unit Production Manager |
| Sound | Ian Tarasoff | Utility Sound |
| Costume & Make-Up | April Boyes | Key Makeup Artist |
| Costume & Make-Up | Danna Rutherford | Key Hair Stylist |
| Art | Mark McQuillen | Construction Foreman |
| Art | Roger Busque | Construction Foreman |
| Production | Michele MacInnes | Production Office Coordinator |
| Art | Dylan Dowd | Greensman |
| Production | Sean Cossey | Casting |
| Camera | Carrie Wilson | Second Assistant "A" Camera |
| Camera | Junichi Hosoi | "A" Camera Operator |
| Camera | Adriene Wyse | Second Assistant "B" Camera |
| Production | Melyssa Rose | Assistant Production Coordinator |
| Visual Effects | Peter V. Ware | Visual Effects Producer |
| Art | Victoria Söderholm | Set Decoration |
| Sound | Roderick Matte | Boom Operator |
| Camera | Karl Herrmann | "B" Camera Operator |
| Costume & Make-Up | Allison Chretien | Costumer |
| Lighting | Rory Soderman | Assistant Chief Lighting Technician |
| Camera | David Kershaw | Dolly Grip |
| Crew | Eric Lemay | Special Effects Coordinator |
| Directing | Carl Mason | First Assistant Director |
| Art | Tyler Bishop Harron | Art Direction |
| Camera | Kieran Humphries | First Assistant "A" Camera |
| Camera | Stephen J. McKnight | First Assistant "B" Camera |
| Production | Stuart Aikins | Casting |
| Production | Jane Mason | Production Accountant |
| Costume & Make-Up | Paulette Nelson | Assistant Costume Designer |
| Camera | John Kuchera | Key Grip |
| Art | David Manske | Set Dresser |
| Production | Paul Russell | Assistant Location Manager |
| Crew | Darren Marcoux | Special Effects Coordinator |
| Lighting | Timothy Hedgecock | Rigging Gaffer |
| Lighting | Derrick Garland | Rigging Grip |
| Lighting | Darren McLean | Chief Lighting Technician |
| Art | Laura Schneider | Assistant Property Master |
| Directing | Jules Stewart | Script Supervisor |
| Camera | Sylvia Pranaitis | Dolly Grip |
| Art | Dean McQuillen | Construction Coordinator |
| Production | Ken Brooker | Location Manager |
| Directing | Josy Capkun | Second Assistant Director |
| Directing | Karin Behrenz | Third Assistant Director |
| Costume & Make-Up | Joel Echallier | Makeup Effects Designer |
| Camera | Paul Arnel | Best Boy Grip |
| Crew | Steve Woodley | Animal Wrangler |
| Crew | Darcy Woodley | Animal Wrangler |
| Crew | Dave Byerley | Transportation Captain |
| Production | Natasha Tony | Extras Casting |
| Visual Effects | Mark A.Z. Dippé | Visual Effects Supervisor |
| Crew | Ron Kozier | Special Effects |
| Crew | Sean P. Aislabie | Craft Service |
| Crew | Bob Dennett | Transportation Coordinator |
| Crew | Jan Kikumoto | Post Production Supervisor |
| Crew | James Kozier | Special Effects |
| Sound | Bryon Speller | Dialogue Editor |
| Sound | Steven Avila | Sound Designer |
| Sound | Trip Brock | Supervising Sound Editor |
| Visual Effects | Park Min-su | Visual Effects Supervisor |
| Sound | Jason Shaffer | Sound Effects Editor |
| Sound | Peter D. Lago | Sound Designer |
| Sound | Alexander Pugh | Sound Effects Editor |
| Sound | Steven Avila | Sound Effects Editor |
| Crew | Wilt Henderson | Visual Effects Editor |
| Editing | Travis Dultz | First Assistant Editor |
| Sound | Brian S.M. Wroth | Dialogue Editor |
| Sound | Mark A. Rozett | Sound Re-Recording Mixer |
| Sound | Kelly Vandever | Sound Re-Recording Mixer |
| Sound | Peter D. Lago | Sound Effects Editor |
| Sound | Doug Latislaw | ADR Mixer |
| Sound | Zac Anderson | Foley Editor |
| Sound | Ben Whitver | ADR Mixer |
| Sound | Kyle Tilbury | Assistant Sound Editor |
| Sound | Steven Utt | Assistant Sound Editor |
| Sound | Greg Mauer | Foley Mixer |
| Sound | Sean Madsen | Assistant Sound Editor |
| Sound | Caleb Easter | Foley Editor |
| Sound | Rick Owens | Foley Artist |
| Editing | Sue Gates | Colorist |
| Crew | Chad Sayn | Stunts |
| Crew | Hugo Steele | Stunts |
