Nadat de tweeling Milo en Maggie, die van elkaar vervreemd zijn geraakt, op dezelfde dag allebei toevallig aan de dood ontsnappen, besluiten ze samen te komen en hun levens onder de loep te nemen. Ze vragen zich allebei af hoe hun levens zo verkeerd hebben kunnen lopen. Maggie zal haar huwelijk met de brave Lance herbekijken, terwijl haar homoseksuele broer Milo zijn oude vlam Rich opzoekt. De tweeling beseft gaandeweg dat hun onderlinge relatie de sleutel tot een gelukkig leven is.
Nee, helaas is The Skeleton Twins nog niet beschikbaar op Netflix in Nederland.
| Production | Roxie Rodriguez | Associate Producer |
| Directing | Craig Johnson | Director |
| Writing | Mark Heyman | Writer |
| Writing | Craig Johnson | Writer |
| Camera | Reed Morano | Director of Photography |
| Sound | Nathan Larson | Original Music Composer |
| Production | Stephanie Langhoff | Producer |
| Production | Jennifer Lee | Producer |
| Production | Jacob Pechenik | Producer |
| Production | Avy Kaufman | Casting |
| Sound | Anton Gold | Sound Mixer |
| Production | Mark Duplass | Executive Producer |
| Production | Jared Ian Goldman | Executive Producer |
| Editing | Jennifer Lee | Editor |
| Costume & Make-Up | Mikaela Wohl | Costume Design |
| Art | Lauren DeTitta | Set Decoration |
| Art | Ola Maslik | Production Design |
| Costume & Make-Up | Valerie Velez | Hair Department Head |
| Costume & Make-Up | Leo Won | Makeup Department Head |
| Sound | Daniel Heffernan | Sound Editor |
| Sound | Matt Schoenfeld | Sound Designer |
| Camera | Reed Morano | Camera Operator |
| Directing | Joseph Ciccarella | First Assistant Director |
| Directing | Anne Marie Dentici | Second Assistant Director |
| Production | Jay Duplass | Executive Producer |
| Costume & Make-Up | Tamika Jackson | Costume Supervisor |
| Sound | Ian Stynes | Sound Re-Recording Mixer |
| Sound | Ian Stynes | Sound Designer |
| Sound | Ian Stynes | Supervising Sound Editor |
| Sound | Shaun Brennan | Foley Artist |
| Camera | Clay Enos | Still Photographer |
