Nadat de tweeling Milo en Maggie, die van elkaar vervreemd zijn geraakt, op dezelfde dag allebei toevallig aan de dood ontsnappen, besluiten ze samen te komen en hun levens onder de loep te nemen. Ze vragen zich allebei af hoe hun levens zo verkeerd hebben kunnen lopen. Maggie zal haar huwelijk met de brave Lance herbekijken, terwijl haar homoseksuele broer Milo zijn oude vlam Rich opzoekt. De tweeling beseft gaandeweg dat hun onderlinge relatie de sleutel tot een gelukkig leven is.
Nee, helaas is The Skeleton Twins nog niet beschikbaar op Netflix in Nederland.
| Production | Roxie Rodriguez | Associate Producer |
| Writing | Craig Johnson | Writer |
| Directing | Craig Johnson | Director |
| Production | Stephanie Langhoff | Producer |
| Production | Jacob Pechenik | Producer |
| Camera | Reed Morano | Director of Photography |
| Sound | Nathan Larson | Original Music Composer |
| Production | Jennifer Lee | Producer |
| Writing | Mark Heyman | Writer |
| Production | Avy Kaufman | Casting |
| Costume & Make-Up | Leo Won | Makeup Department Head |
| Sound | Anton Gold | Sound Mixer |
| Production | Mark Duplass | Executive Producer |
| Costume & Make-Up | Valerie Velez | Hair Department Head |
| Production | Jared Ian Goldman | Executive Producer |
| Camera | Reed Morano | Camera Operator |
| Costume & Make-Up | Mikaela Wohl | Costume Design |
| Art | Ola Maslik | Production Design |
| Directing | Joseph Ciccarella | First Assistant Director |
| Directing | Anne Marie Dentici | Second Assistant Director |
| Sound | Matt Schoenfeld | Sound Designer |
| Art | Lauren DeTitta | Set Decoration |
| Sound | Daniel Heffernan | Sound Editor |
| Editing | Jennifer Lee | Editor |
| Production | Jay Duplass | Executive Producer |
| Costume & Make-Up | Tamika Jackson | Costume Supervisor |
| Sound | Ian Stynes | Supervising Sound Editor |
| Sound | Ian Stynes | Sound Designer |
| Sound | Shaun Brennan | Foley Artist |
| Sound | Ian Stynes | Sound Re-Recording Mixer |
| Camera | Clay Enos | Still Photographer |
