CIA agent Sean Davidson en zijn hulpje Carl moeten het opnemen tegen de sadistische Britse ex-soldaat Mulgrew, om een stel gevangengenomen Delta Force Commando's te redden. Als Sean, Carl en de mooie dokter, Sarah, in problemen komen, komt Joe Armstrong te hulp om de snode plannen van Mulgrew te stoppen.
Nee, helaas is American Ninja 4: The Annihilation nog niet beschikbaar op Netflix in Nederland.
| Writing | Avi Kleinberger | Characters |
| Art | Ruth Strimling | Production Design |
| Production | Ovidio G. Assonitis | Producer |
| Production | Christopher Pearce | Producer |
| Editing | Claudio M. Cutry | Editor |
| Camera | Yossi Wein | Director of Photography |
| Writing | Gideon Amir | Characters |
| Production | Gianna Pisanello | Casting |
| Sound | Nic. tenBroek | Original Music Composer |
| Production | Avi Lerner | Executive Producer |
| Directing | Cedric Sundstrom | Director |
| Writing | David Geeves | Screenplay |
| Directing | Rozelle Vogelman | Continuity |
| Sound | Andy Newell | Sound Effects Editor |
| Sound | Ian McFarlane | Sound Mixer |
| Costume & Make-Up | Cleone Johnson | Makeup & Hair Assistant |
| Visual Effects | Greg Pitts | Special Effects Supervisor |
| Sound | Jim McKee | Sound Effects Editor |
| Art | Emilia Roux | Set Decoration |
| Directing | Guy Stodel | Second Assistant Director |
| Sound | Stanley B. Gill | Sound Recordist |
| Directing | Nicole Perrow | Second Assistant Director |
| Directing | Leigh Page | Third Assistant Director |
| Sound | Thierry J. Couturier | Sound Editor |
| Costume & Make-Up | Richard Miranda | Special Effects Makeup Artist |
| Directing | Willie Naude | First Assistant Director |
