CIA agent Sean Davidson en zijn hulpje Carl moeten het opnemen tegen de sadistische Britse ex-soldaat Mulgrew, om een stel gevangengenomen Delta Force Commando's te redden. Als Sean, Carl en de mooie dokter, Sarah, in problemen komen, komt Joe Armstrong te hulp om de snode plannen van Mulgrew te stoppen.
Nee, helaas is American Ninja 4: The Annihilation nog niet beschikbaar op Netflix in Nederland.
| Writing | Gideon Amir | Characters |
| Editing | Claudio M. Cutry | Editor |
| Art | Ruth Strimling | Production Design |
| Writing | Avi Kleinberger | Characters |
| Sound | Nic. tenBroek | Original Music Composer |
| Production | Avi Lerner | Executive Producer |
| Directing | Cedric Sundstrom | Director |
| Production | Ovidio G. Assonitis | Producer |
| Production | Christopher Pearce | Producer |
| Camera | Yossi Wein | Director of Photography |
| Production | Gianna Pisanello | Casting |
| Writing | David Geeves | Screenplay |
| Directing | Leigh Page | Third Assistant Director |
| Directing | Guy Stodel | Second Assistant Director |
| Sound | Stanley B. Gill | Sound Recordist |
| Sound | Andy Newell | Sound Effects Editor |
| Directing | Nicole Perrow | Second Assistant Director |
| Costume & Make-Up | Cleone Johnson | Makeup & Hair Assistant |
| Sound | Thierry J. Couturier | Sound Editor |
| Sound | Ian McFarlane | Sound Mixer |
| Visual Effects | Greg Pitts | Special Effects Supervisor |
| Costume & Make-Up | Richard Miranda | Special Effects Makeup Artist |
| Sound | Jim McKee | Sound Effects Editor |
| Art | Emilia Roux | Set Decoration |
| Directing | Willie Naude | First Assistant Director |
| Directing | Rozelle Vogelman | Continuity |
