Een schip van het Amerikaans leger zinkt vlakbij een eiland. Het blijkt dat er aan boord van het schip genetisch gemanipuleerde piranha's zijn. Anne Kimbrough komt hier achter omdat ze de dood van haar zoon heeft onderzocht, ze wil alarm slaan maar een hotelmanager is het daarmee niet eens.
Nee, helaas is Piranha II: The Spawning nog niet beschikbaar op Netflix in Nederland.
| Directing | James Cameron | Director |
| Production | Ovidio G. Assonitis | Executive Producer |
| Production | Jeff Schechtman | Producer |
| Production | 筑波久子 | Producer |
| Sound | Stelvio Cipriani | Original Music Composer |
| Crew | Roberto D'Ettorre Piazzoli | Cinematography |
| Writing | James Cameron | Screenplay |
| Writing | Ovidio G. Assonitis | Screenplay |
| Writing | Charles H. Eglee | Screenplay |
| Art | Vincenzo Medusa | Art Direction |
| Editing | Roberto Silvi | Editor |
| Art | Stefano Paltrinieri | Art Direction |
| Art | Franco Vanorio | Art Direction |
| Costume & Make-Up | Nicoletta Ercole | Costume Design |
| Costume & Make-Up | Mirella De Rossi | Hairstylist |
| Costume & Make-Up | Maurizio Trani | Makeup Artist |
| Directing | Ruggero Salvadori | Assistant Director |
| Directing | Alessandro Vivarelli | Assistant Director |
| Art | Stephane Goulet | Property Master |
| Art | Ronnie Lombard | Greensman |
| Sound | Roberto Edwin Forrest | Boom Operator |
| Sound | Alessandro Peticca | Sound Editor |
| Visual Effects | Giannetto De Rossi | Special Effects Supervisor |
| Camera | Ennio Brizzolari | Key Grip |
| Camera | Gianni Caramanico | Still Photographer |
| Camera | Roberto Forges Davanzati | Underwater Camera |
| Camera | Roberto D'Ettorre Piazzoli | Underwater Director of Photography |
| Camera | Erich Heindl | Underwater Camera |
| Camera | Carlo Tafani | Camera Operator |
| Lighting | Gino Pasquallini | Electrician |
| Editing | Ada Grimaldi | Assistant Editor |
| Camera | Roberto D'Ettorre Piazzoli | Director of Photography |
