In de nabije toekomst heeft Amerika de strijd tegen drugs verloren en laten geheimagenten naast hun identiteit ook hun gezicht veranderen. Fred (Keanu Reeves) is zo’n undercoveragent, die een probleem krijgt wanneer hij teveel drugs (het populaire Substance D.) gebruikt, waardoor hij schizofreen wordt. Hierdoor ontstaat Fred's alter ego Bob, een meedogenloze drugsdealer.
Nee, helaas is A Scanner Darkly nog niet beschikbaar op Netflix in Nederland.
| Art | Bruce Curtis | Production Design |
| Production | George Clooney | Executive Producer |
| Production | Steven Soderbergh | Executive Producer |
| Production | Palmer West | Producer |
| Editing | Sandra Adair | Editor |
| Writing | Richard Linklater | Screenplay |
| Camera | Shane F. Kelly | Director of Photography |
| Production | Anne Walker-McBay | Producer |
| Production | Jonah Smith | Producer |
| Sound | Graham Reynolds | Original Music Composer |
| Production | Denise Chamian | Casting |
| Production | Jennifer Fox | Executive Producer |
| Directing | Richard Linklater | Director |
| Production | Tommy Pallotta | Producer |
| Art | Joaquin A. Morin | Set Decoration |
| Production | Erwin Stoff | Producer |
| Writing | Philip K. Dick | Novel |
| Production | Ben Cosgrove | Executive Producer |
| Production | John Sloss | Executive Producer |
| Visual Effects | Sterling Allen | Lead Animator |
| Visual Effects | Evan Cagle | Lead Animator |
| Visual Effects | Nick Derington | Lead Animator |
| Sound | Tom Hammond | Sound Designer |
| Sound | Justin Hennard | Sound Effects Editor |
| Sound | Skip Lievsay | Sound Re-Recording Mixer |
| Visual Effects | Jason Archer | Head of Animation |
| Sound | Jeremy Peirson | Sound Re-Recording Mixer |
| Visual Effects | Richard Gordoa | Visual Effects Supervisor |
| Art | Fred Daniel | Art Department Coordinator |
| Directing | Brooke Satrazemis | Script Supervisor |
| Costume & Make-Up | Darylin Nagy | Makeup Department Head |
| Costume & Make-Up | Melanie Armstrong Fletcher | Costume Supervisor |
| Costume & Make-Up | Kari Perkins | Costume Design |
| Costume & Make-Up | Darylin Nagy | Hair Department Head |
| Art | Raymond Consing | Storyboard Artist |
| Sound | Gregg Barbanell | Foley Artist |
| Art | Michael P. Garza | Title Designer |
| Sound | Ajae Clearway | Dialogue Editor |
| Sound | Bruce Colson | Musician |
| Production | Shannon Blackburn | Production Secretary |
| Costume & Make-Up | Katina Gilkey | Hairstylist |
| Directing | Andrew Payer | Second Second Assistant Director |
| Directing | Kathie Tull | Second Assistant Director |
| Production | Beth Sepko | Local Casting |
| Sound | Tom Hammond | Supervising Sound Editor |
| Sound | Thomas J. O'Connell | ADR Mixer |
| Camera | Peter Simonite | First Assistant Camera |
| Sound | Peter Germansen | Sound Engineer |
| Production | Susan Kirr | Unit Production Manager |
| Production | Scout Masterson | Casting Associate |
| Production | Dustin Weaver | Assistant Location Manager |
| Sound | Tom Sturgis | Boom Operator |
| Crew | Tod Campbell | Loader |
| Production | Dominic Cancilla | Production Coordinator |
| Crew | Melody Lloyd | Set Medic |
| Sound | Ethan Andrus | Production Sound Mixer |
| Production | Peter Atherton | Location Manager |
| Production | Morgan Miles | Production Accountant |
| Crew | Tracey Schaefer | Unit Publicist |
| Art | Brad Blei | Set Dresser |
| Costume & Make-Up | Melanie Ferguson | On Set Dresser |
| Camera | Matt Lankes | Still Photographer |
| Lighting | Robert B. Reynolds | Chief Lighting Technician |
| Editing | Christopher Roldan | First Assistant Editor |
| Sound | Nic Ratner | Music Supervisor |
| Production | Sara Johnson | Associate Producer |
| Camera | Matt Cowan | Best Boy Grip |
| Camera | Aaron Atom Vyvial | Key Grip |
| Art | Ian Sebastian Kasnoff | Construction Coordinator |
| Crew | Jesus F. Tellez | Transportation Captain |
| Art | Erick Garibay | Assistant Property Master |
| Sound | Michael Swanner | Utility Sound |
| Crew | Lisa Del Dotto | Assistant Craft Service |
| Production | Erin Ferguson | Co-Producer |
| Directing | Vincent Palmo Jr. | First Assistant Director |
| Sound | Jason Piatt | Foley Mixer |
| Crew | Steve Krieger | Special Effects Coordinator |
| Sound | Ajae Clearway | ADR Editor |
| Crew | Ronald D. Chambers | Transportation Coordinator |
| Camera | Michael Reyes | Grip |
| Crew | Gil Dean | Animal Wrangler |
| Art | Stefan Wilcox | Property Master |
| Lighting | Josh Taylor | Assistant Chief Lighting Technician |
| Camera | Ralph Watson | Camera Operator |
