Er heeft zich een vreemde mutatie voorgedaan in de vampierenwereld, genaamd The Reaper. De bloeddorst van deze vampieren is zo groot dat ze het op zowel mensen als andere vampiers voorzien hebben. Blade en Whistler besluiten samen te werken met The Bloodpackt, een elite team vampiers, aangezien ze dit maal een gezamenlijk doel hebben.
Nee, helaas is Blade II nog niet beschikbaar op Netflix in Nederland.
| Directing | Guillermo del Toro | Director |
| Writing | David S. Goyer | Writer |
| Writing | Marv Wolfman | Characters |
| Writing | Gene Colan | Characters |
| Production | Peter Frankfurt | Producer |
| Production | Patrick J. Palmer | Producer |
| Production | Wesley Snipes | Producer |
| Production | Avi Arad | Executive Producer |
| Production | Michael De Luca | Executive Producer |
| Production | Toby Emmerich | Executive Producer |
| Production | David S. Goyer | Executive Producer |
| Production | Lynn Harris | Executive Producer |
| Production | Stan Lee | Executive Producer |
| Sound | Marco Beltrami | Original Music Composer |
| Camera | Gabriel Beristain | Director of Photography |
| Editing | Peter Amundson | Editor |
| Production | Nancy Foy | Casting |
| Costume & Make-Up | Wendy Partridge | Costume Design |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Clay Cullen | Stunts |
| Art | Carol Spier | Production Design |
| Art | Dan Morski | Co-Art Director |
| Art | Jaromír Švarc | Art Direction |
| Art | James F. Truesdale | Art Direction |
| Art | Jeffrey Kushon | Set Decoration |
| Art | Peter Nicolakakos | Set Decoration |
| Costume & Make-Up | Nikita Rae | Makeup Artist |
| Costume & Make-Up | Michelle Taylor | Makeup Artist |
| Costume & Make-Up | Jeanette Freeman | Hairstylist |
| Production | Pavel Typolt | Production Manager |
| Production | Michelle Weller | Production Supervisor |
| Production | Wendy Cox | Production Supervisor |
| Art | Mike Hyrman | Art Department Coordinator |
| Art | Phillip Tellez | Construction Coordinator |
| Art | Bruce DiValerio | Construction Coordinator |
| Art | Milena Koubková | Set Designer |
| Art | Michael Madden | Set Designer |
| Art | Gordon White | Set Designer |
| Art | Martin Vačkář | Assistant Art Director |
| Art | Constantine Sekeris | Conceptual Design |
| Sound | Scott Martin Gershin | Supervising Sound Editor |
| Sound | Scott Martin Gershin | Sound Designer |
| Sound | Mathew Waters | Supervising Sound Editor |
| Sound | Michael Keller | Sound Re-Recording Mixer |
| Sound | John Ross | Sound Re-Recording Mixer |
| Crew | Barbora Kolarova | Special Effects Coordinator |
| Visual Effects | Terry Bradley | Visual Effects Supervisor |
| Visual Effects | Nicholas Brooks | Visual Effects Supervisor |
| Visual Effects | Blair Clark | Visual Effects Supervisor |
| Visual Effects | Robert Duncan | Visual Effects Supervisor |
| Crew | Peter S. Elliot | Visual Effects Editor |
| Visual Effects | Craig Hayes | Visual Effects Supervisor |
| Visual Effects | Justin Martin | Visual Effects Supervisor |
| Visual Effects | Bob Munroe | Visual Effects Supervisor |
| Visual Effects | Dominic Parker | Visual Effects Supervisor |
| Visual Effects | Nordin Rahhali | Visual Effects Supervisor |
| Crew | Sarah Schubart | Visual Effects Editor |
| Visual Effects | David Sosalla | Visual Effects Supervisor |
| Crew | Dirk Westervelt | Visual Effects Editor |
| Visual Effects | Ruth Greenberg | Visual Effects Producer |
| Visual Effects | Edward Irastorza | Visual Effects Producer |
| Visual Effects | Susan MacLeod | Visual Effects Producer |
| Visual Effects | George Macri | Visual Effects Producer |
| Visual Effects | Dominic Sidoli | Visual Effects Producer |
| Crew | Pavel Cajzl | Stunt Coordinator |
| Camera | Klaus Fuxjäger | Camera Operator |
| Camera | Anthony Gaudioz | Camera Operator |
| Camera | Craig Fikse | Steadicam Operator |
| Camera | Guy Hodgen | Additional Camera |
| Crew | Viktor Lonek | Video Assist Operator |
| Lighting | Jaromir Simek | Gaffer |
| Lighting | H. Mark Vuille | Gaffer |
| Sound | Bill Abbott | Music Editor |
| Sound | Brian Richards | Music Editor |
| Crew | Vaclav Mottl | Transportation Coordinator |
| Crew | Aaron Skalka | Transportation Coordinator |
| Production | Douglas Dresser | Location Manager |
| Production | Pavel Sterba | Location Manager |
| Crew | Jon Sperry | Dialect Coach |
| Crew | Marianna Krenova | Stand In |
| Crew | Moira Houlihan | Unit Publicist |
| Crew | Lane Leavitt | Stunts |
| Production | John T. Sweeney | Production Coordinator |
| Art | Jan Kodera | Leadman |
| Art | Tim Larsen | Painter |
| Art | John Weldy | Sculptor |
| Camera | Ladislav Hrubý | First Assistant Camera |
| Costume & Make-Up | Kelly Fraser | Assistant Costume Designer |
| Costume & Make-Up | Marese Langan | Key Hair Stylist |
| Costume & Make-Up | David Dupuis | Prosthetic Supervisor |
| Crew | Danny Saber | Additional Music |
| Crew | James Weston | Armorer |
| Crew | Chris Sposa | Cableman |
| Crew | Mark Fattibene | CG Supervisor |
| Crew | Ladislav Beran | Choreographer |
| Crew | Chris Ferrence | Driver |
| Crew | Jeff Ward | Martial Arts Choreographer |
| Crew | Jayson Wall | Post Production Assistant |
| Crew | Sara Romilly | Post Production Supervisor |
| Crew | Alex Matcham | Production Controller |
| Crew | Eva Dvorakova | Set Medic |
| Crew | Phred Lender | Systems Administrators & Support |
| Crew | Keith D. Fisher | Transportation Captain |
| Crew | Freddy Bouciegues | Utility Stunts |
| Directing | Claudine Strasser | Script Supervisor |
| Editing | Dan Muscarella | Color Timer |
| Editing | Laura Rindner | First Assistant Editor |
| Lighting | Ben Bowling | Electrician |
| Lighting | Mike Macias | Lighting Technician |
| Lighting | Petr Svoboda | Rigging Gaffer |
| Lighting | Michal Houzvicka | Rigging Grip |
| Production | Robert Bernacchi | Associate Producer |
| Production | Jon Divens | Co-Producer |
| Production | Andrew J. Horne | Co-Producer |
| Production | Andrea Clark | Casting Associate |
| Production | Jiri Tichacek | Production Accountant |
| Production | Sissy Grover | Production Coordinator |
| Sound | Peter Eusebe | Boom Operator |
| Sound | Happy Walters | Music Supervisor |
| Sound | Mark Holding | Production Sound Mixer |
| Sound | John Kurlander | Scoring Mixer |
| Sound | Hector C. Gika | Sound Editor |
| Sound | Bryan Bowen | Sound Effects Editor |
| Sound | Nerses Gezalyan | Sound mixer |
| Visual Effects | Asregadoo Arundi | Digital Compositors |
| Visual Effects | Nick Allder | Special Effects Supervisor |
| Visual Effects | Kandece Brown | Visual Effects Coordinator |
| Writing | Jason Brubaker | Storyboard |
| Visual Effects | Wayne D. Barlowe | Creature Design |
| Visual Effects | Steve Watson | 24 Frame Playback |
| Visual Effects | David Rosenthal | I/O Supervisor |
| Visual Effects | Vicki Wong | I/O Manager |
| Production | Robert Bernacchi | Unit Production Manager |
| Art | Elinor Rose Galbraith | Supervising Art Director |
| Art | Miroslav Čáslavka | Set Dresser |
| Camera | Alexandre Szabo-Fresnais | Camera Loader |
| Camera | Bill Daimant | Dolly Grip |
| Camera | Malcolm Sheehan | Key Grip |
| Camera | John Emory | Grip |
| Costume & Make-Up | Heather Moore | Key Costumer |
| Costume & Make-Up | David Dupuis | Key Makeup Artist |
| Costume & Make-Up | Nigel Booth | Prosthetic Makeup Artist |
| Crew | Clayton J. Barber | Fight Choreographer |
| Crew | Libor Hatas | Pilot |
| Directing | Julian Wall | First Assistant Director |
| Directing | Philip Seeger | Third Assistant Director |
| Editing | Jana Lynn Gold | Associate Editor |
| Editing | Gary Burritt | Negative Cutter |
| Production | Stephani Hunter | Assistant Production Coordinator |
| Production | Clive Miles | Assistant Production Manager |
| Production | Minna Pyyhkala | Casting Assistant |
| Sound | Michael Hertlein | ADR Editor |
| Sound | Thomas Jones | ADR Supervisor |
| Sound | Susan Cahill | Assistant Sound Editor |
| Sound | Pete Anthony | Conductor |
| Sound | Craig Jurkiewicz | Foley Editor |
| Sound | Tom Boyd | Musician |
| Visual Effects | Paul Anderson | 3D Artist |
| Visual Effects | Jerry Corda-Stanley | CG Animator |
| Visual Effects | Warren J.W. Leathem | Lead Animator |
| Crew | Jonathan Eusebio | Stunts |
| Art | Greg Runnels | Swing |
| Sound | Robert Getty | Dialogue Editor |
| Sound | Louis Creveling | Dialogue Editor |
| Sound | Jed M. Dodge | Dialogue Editor |
| Sound | Michael Hertlein | Dialogue Editor |
| Sound | Greg Zimmerman | Foley Recordist |
| Sound | Matt Colleran | Sound Recordist |
| Camera | Simon Werry | Aerial Camera |
| Art | Gert Broekema | Property Master |
| Art | Michael Lindsay | Property Master |
| Directing | Mark Taylor | Second Assistant Director |
| Crew | Gary Powell | Stunts |
| Costume & Make-Up | Barrie Gower | Prosthetic Makeup Artist |
| Costume & Make-Up | Jemma Scott-Knox-Gore | Contact Lens Technician |
| Directing | Martina Götthansova | Second Second Assistant Director |
| Art | TyRuben Ellingson | Concept Artist |
| Art | Leo Duranona | Storyboard Artist |
| Sound | Ron Bedrosian | ADR Mixer |
| Sound | Brian Basham | ADR Recordist |
| Sound | Nerses Gezalyan | Foley Mixer |
| Crew | Jan Beran | Special Effects Technician |
| Visual Effects | Ian Unterreiner | Visual Effects Production Assistant |
| Visual Effects | Lisa Bechard | Visual Effects Production Manager |
| Crew | Nikki Berwick | Stunt Double |
| Camera | Kenny Groom | Assistant Camera |
| Camera | Darrel Griffin | Data Wrangler |
| Camera | Chas Bain | Focus Puller |
| Camera | Alexander Bscheidl | Second Assistant Camera |
| Editing | Josh Campbell | Assistant Editor |
| Editing | Jim Garrow | Colorist |
| Editing | Adam Glasman | Digital Colorist |
| Production | Betty Burkhart | Post Production Coordinator |
| Production | David Antol | Location Assistant |
| Sound | Dave Jordan | Music Consultant |
| Sound | Jim Ervin | Music Producer |
| Crew | Natasha Ivanova | Additional Dialogue |
| Production | Vera Trousilová | Assistant Accountant |
| Lighting | Michael K. O'Melia | Assistant Chief Lighting Technician |
| Visual Effects | Clay Dale | CG Artist |
| Visual Effects | Avtar Bains | Compositing Artist |
| Production | Petr Brodsky | Extras Casting |
| Production | Rob Seager | First Assistant Accountant |
| Production | Ray Scalice | General Manager |
| Production | Alonzo Ruvalcaba | Head of Production |
| Crew | John Bannister | Key Scenic Artist |
| Production | Jennifer Hunt Pedevilla | Payroll Accountant |
| Production | Tyler Ham | Production Assistant |
| Production | Leon Dudevoir | Production Executive |
| Production | Cammeron Truesdale | Production Runner |
| Visual Effects | Dan Feinstein | Rotoscoping Artist |
| Visual Effects | Ray McIntyre Jr. | Visual Effects Supervisor |
| Crew | 甄子丹 | Martial Arts Choreographer |
| Directing | Gregory Palmer | Second Assistant Director |
| Visual Effects | Drew Jones | Visual Effects Producer |
