Wanneer een onbekende, vermoedelijk een mutant met buitengewone krachten, de president aanvalt krijgen de mutanten met nog meer argwaan en discriminatie te maken dan al het geval was. Er komt bredere steun in de samenleving voor een registratieplicht voor mutanten. Militair leider William Stryker is één van de grootste voorstanders van dit plan, en leidt een aanval op de X-Men opleiding. De ontsnapte Magneto begint een opmerkelijke samenwerking met Professor Xavier om Stryker te stoppen. Ondertussen begint Wolverine een onderzoek naar zijn verleden.
Nee, helaas is X-Men 2 nog niet beschikbaar op Netflix in Nederland.
| Writing | Zak Penn | Story |
| Writing | David Hayter | Story |
| Writing | Bryan Singer | Story |
| Writing | Michael Dougherty | Screenplay |
| Writing | Dan Harris | Screenplay |
| Writing | David Hayter | Screenplay |
| Directing | Bryan Singer | Director |
| Crew | Terry Notary | Choreographer |
| Editing | Elliot Graham | Co-Editor |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Costume & Make-Up | Gordon J. Smith | Special Effects Makeup Artist |
| Production | Ross T. Fanger | Unit Production Manager |
| Production | Stewart Bethune | Unit Production Manager |
| Directing | Lee Cleary | First Assistant Director |
| Directing | David Arnold | Second Assistant Director |
| Production | Jason McGatlin | Production Supervisor |
| Art | Barbara Wilson | Assistant Art Director |
| Art | Brentan Harron | Assistant Art Director |
| Art | Ignacio McBurney | Assistant Set Decoration |
| Art | Ron Sowden | Assistant Set Decoration |
| Art | Franziska Keller | Art Department Coordinator |
| Art | Aimee Rousey | Art Department Coordinator |
| Directing | Gerrod Shully | Second Second Assistant Director |
| Directing | Silver Butler | Third Assistant Director |
| Camera | Tim Merkel | Steadicam Operator |
| Camera | Tim Merkel | "B" Camera Operator |
| Camera | Jimmy E. Jensen | First Assistant "A" Camera |
| Camera | Sean M. Harding | First Assistant "B" Camera |
| Camera | Kerry Hayes | Still Photographer |
| Camera | Doane Gregory | Still Photographer |
| Sound | Rob Young | Sound Mixer |
| Sound | Jon Lavender | Boom Operator |
| Crew | Andy Bishop | Cableman |
| Art | Jimmy Chow | Property Master |
| Art | Catherine Leighton | Assistant Property Master |
| Art | Jason B. Landels | Assistant Property Master |
| Crew | Rob Fournier | Armorer |
| Camera | Steve Smith | Key Grip |
| Costume & Make-Up | Cathy Crandall | Assistant Costume Designer |
| Costume & Make-Up | Janice Swayze | Costume Coordinator |
| Editing | Dov Samuel | First Assistant Editor |
| Sound | John A. Larsen | Supervising Sound Editor |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Sound | Michael Herbick | Sound Re-Recording Mixer |
| Sound | Susan Dawes | Dialogue Editor |
| Sound | Jim Brookshire | Dialogue Editor |
| Sound | Donald Sylvester | ADR Supervisor |
| Sound | Laura Graham | ADR Editor |
| Sound | John Morris | Foley Supervisor |
| Sound | Amanda Goodpaster | Music Editor |
| Editing | Gary Burritt | Negative Cutter |
| Editing | Jim Passon | Color Timer |
| Editing | Chris Regan | Color Timer |
| Editing | Elliot Graham | Editor |
| Production | Lauren Shuler Donner | Producer |
| Production | Ralph Winter | Producer |
| Camera | Newton Thomas Sigel | Director of Photography |
| Editing | John Ottman | Editor |
| Art | Guy Hendrix Dyas | Production Design |
| Art | Helen Jarvis | Art Direction |
| Art | Elizabeth Wilcox | Set Decoration |
| Costume & Make-Up | Louise Mingenbach | Costume Design |
| Crew | Dane Farwell | Stunts |
| Production | Roger Mussenden | Casting |
| Visual Effects | Angie Jones | Animation |
| Visual Effects | Andy Asperin | Animation |
| Crew | Lauro David Chartrand-DelValle | Stunts |
| Crew | James Bamford | Stunts |
| Crew | J.J. Makaro | Stunts |
| Crew | Doug Chapman | Stunts |
| Sound | Michael Herbick | Sound Mixer |
| Art | Geoff Hubbard | Supervising Art Director |
| Crew | Jeffrey Cassidy | Video Assist Operator |
| Production | Kevin Feige | Co-Producer |
| Directing | Christine Wilson | Script Supervisor |
| Visual Effects | Andrew Tamandl | VFX Artist |
| Sound | John Ottman | Original Music Composer |
| Art | Rick Newsome | Storyboard Designer |
| Crew | Melissa R. Stubbs | Stunt Coordinator |
| Crew | Rick Pearce | Stunts |
| Crew | Marny Eng | Stunt Double |
| Production | Avi Arad | Executive Producer |
| Production | Tom DeSanto | Executive Producer |
| Production | Ross T. Fanger | Co-Producer |
| Production | David Gorder | Associate Producer |
| Production | Stan Lee | Executive Producer |
| Production | John H. Radulovic | Line Producer |
| Production | Selwyn Roberts | Line Producer |
| Production | Bryan Singer | Executive Producer |
| Directing | Brian Smrz | Second Unit Director |
| Visual Effects | Ray McIntyre Jr. | Visual Effects Supervisor |
| Art | Melanie Cassidy | Art Department Assistant |
