Frank Adler is een vrijgezel die zijn hoogbegaafde nichtje, Mary genaamd, opvoedt in een kustplaatsje in Florida. Frank probeert ervoor te zorgen dat Mary een normaal leven kan leiden. Zijn plannen worden gedwarsboomd als zijn moeder de wiskundige talenten van het meisje ontdekt en plannen maakt om Frank en Mary uit elkaar te halen.
| Directing | Marc Webb | Director |
| Writing | Tom Flynn | Writer |
| Production | Andy Cohen | Producer |
| Production | Karen Lunder | Producer |
| Editing | Bill Pankow | Editor |
| Sound | Tom Brown | Music Arranger |
| Camera | Stuart Dryburgh | Director of Photography |
| Sound | Rob Simonsen | Original Music Composer |
| Production | Glen Basner | Executive Producer |
| Production | Ben Browning | Executive Producer |
| Production | Molly Allen | Executive Producer |
| Costume & Make-Up | Abby O'Sullivan | Costume Design |
| Art | Laura Fox | Production Design |
| Production | David Rubin | Casting |
| Directing | Michael J. Leone | Script Supervisor |
| Production | T.K. Knowles | Associate Producer |
| Production | John O'Grady | Associate Producer |
| Production | Chuck Ryant | Associate Producer |
| Art | Charles Varga | Art Direction |
| Art | Vera Mills | Set Decoration |
| Costume & Make-Up | Michal Bigger | Makeup Department Head |
| Costume & Make-Up | Andrea Bowman | Key Hair Stylist |
| Costume & Make-Up | J.C. Davis | Hairstylist |
| Costume & Make-Up | Tiffany Lord | Hairstylist |
| Costume & Make-Up | Rita Parillo | Hair Department Head |
| Costume & Make-Up | Valerie Patterson | Makeup Artist |
| Costume & Make-Up | Susan Ransom | Key Makeup Artist |
| Costume & Make-Up | Joan Shay | Hairstylist |
| Costume & Make-Up | Nico Sohn | Makeup Artist |
| Production | Molly Allen | Unit Production Manager |
| Crew | Paul A. Levin | Post Production Supervisor |
| Production | Peggy Robinson | Production Supervisor |
| Directing | Jon Mallard | First Assistant Director |
| Directing | Mark C. Stevens | Second Assistant Director |
| Art | Gillian Albinski | Property Master |
| Crew | E. Paul Anderson | Prop Maker |
| Art | Steven P. Brown | Painter |
| Art | Patrick Fuhrman | Leadman |
| Art | Justin Nathaniel Kistler | Art Department Coordinator |
| Crew | Raymond Talley | Carpenter |
| Art | Scott B. Warner | Construction Foreman |
| Art | Scott D. Warner | Construction Coordinator |
| Art | Douglas G. Young | Assistant Property Master |
| Sound | Ron Bochar | Supervising Sound Editor |
| Sound | Timothy Cargioli | Boom Operator |
| Sound | Jason Chiodo | Sound Re-Recording Mixer |
| Sound | Patrick Christensen | ADR Mixer |
| Sound | Marko Costanzo | Foley Artist |
| Sound | Jesse Dodd | ADR Mixer |
| Sound | Mitch Dorf | ADR Mixer |
| Sound | Paul Hsu | Sound Effects Editor |
| Sound | Nick Jimenez | ADR Recordist |
| Sound | Bobby Johanson | ADR Mixer |
| Sound | Tony Kiernan | ADR Recordist |
| Sound | George A. Lara | Foley Mixer |
| Sound | Marissa Littlefield | ADR Editor |
| Sound | Michael Miller | ADR Mixer |
| Sound | Philip Stockton | Dialogue Editor |
| Sound | Sarah Streit | Assistant Sound Editor |
| Sound | Sara Stern | Dialogue Editor |
| Sound | Steven Visscher | Foley Editor |
| Sound | Dave Wilson | ADR Mixer |
| Visual Effects | Eran Dinur | Visual Effects Supervisor |
| Crew | Keith Adams | Stunt Coordinator |
| Crew | Chick Bernhard | Stunts |
| Crew | Rosie Bernhard | Stunts |
| Crew | Max Calder | Stunts |
| Crew | Laurence Chavez | Stunts |
| Crew | Stephen Conroy | Stunts |
| Crew | Eduardo Marques de Oliveira Jr. | Stunts |
| Crew | Nick DeKay | Stunt Double |
| Crew | Yan Dron | Stunts |
| Crew | Adam S. Katz | Stunts |
| Crew | Kevin LaRosa Jr. | Stunts |
| Crew | Deven MacNair | Stunts |
| Crew | Jeff Medeiros | Stunts |
| Lighting | Keith 'Zoot' Byrne | Gaffer |
| Lighting | Thomas H. Dean | Best Boy Electric |
| Lighting | Robyn Greer | Rigging Grip |
| Camera | Richard Henkels | Camera Operator |
| Camera | Michael Paul Jones | Camera Operator |
| Camera | Chris Koch | Dolly Grip |
| Camera | E.J. Misisco | First Assistant "A" Camera |
| Camera | John S. Moyer | Steadicam Operator |
| Camera | Kane Pearson | Second Assistant "B" Camera |
| Camera | Tim Rook | Dolly Grip |
| Camera | T. Daniel Scaringi | Key Grip |
| Camera | Wilson Webb | Still Photographer |
| Production | Melissa Pryor | Casting Associate |
| Costume & Make-Up | Suzy Freeman | Costume Supervisor |
| Costume & Make-Up | Gina Ruiz | Assistant Costume Designer |
| Editing | Misako Shimizu | First Assistant Editor |
| Production | Bass Hampton | Location Manager |
| Sound | Meghan Currier | Music Supervisor |
| Sound | Todd Kasow | Music Editor |
| Sound | Randall Poster | Music Supervisor |
| Crew | Bruce Cheek | Set Medic |
| Crew | Margaret King | Set Medic |
| Production | Phil LoGrippo | Production Accountant |
| Crew | Mary Ann Lynah | Studio Teacher |
| Production | Heather Neeld | Production Coordinator |
| Crew | Kevin R. Stephens | Set Medic |
| Crew | Lois Yaroshefsky | Studio Teacher |
| Crew | Trey Gordon | Special Effects Coordinator |
