De in Pakistaan geboren Kumail heeft een relatie met een Amerikaanse vrouw, Emily. Samen moet ze de verwachtingen zien te overwinnen van zijn familie en hun 1400 jaar oude tradities. Zijn ouders blijven hem onophoudelijk bestoken met potentiële bruiden voor een gearrangeerd huwelijk.
Nee, helaas is The Big Sick nog niet beschikbaar op Netflix in Nederland.
| Crew | Joe Schultz | Driver |
| Sound | Tara A. Paul | Sound Re-Recording Mixer |
| Directing | Michael Showalter | Director |
| Production | Judd Apatow | Producer |
| Production | Barry Mendel | Producer |
| Writing | Kumail Nanjiani | Screenplay |
| Writing | Emily V. Gordon | Screenplay |
| Costume & Make-Up | Sarah Mae Burton | Costume Designer |
| Production | Jeremy Kipp Walker | Executive Producer |
| Art | Brandon Tonner-Connolly | Production Design |
| Editing | Robert Nassau | Editor |
| Camera | Brian Burgoyne | Director of Photography |
| Sound | Michael Andrews | Original Music Composer |
| Art | Lauren J. Brown | Property Master |
| Art | William Smith | Set Dresser |
| Production | Gayle Keller | Casting |
| Sound | Joe Rudge | Music Supervisor |
| Production | Amanda Glaze | Co-Producer |
| Production | Glen Basner | Executive Producer |
| Production | Ben Browning | Executive Producer |
| Production | Kumail Nanjiani | Executive Producer |
| Production | Emily V. Gordon | Executive Producer |
| Production | Jeremy Kipp Walker | Unit Production Manager |
| Directing | Nicholas Bell | First Assistant Director |
| Directing | Adam J. Bernard | Second Assistant Director |
| Crew | Jeremy Sample | Stunt Coordinator |
| Production | Annie Tan | Production Supervisor |
| Directing | Mariana Hellmund | Script Supervisor |
| Camera | Yousheng Tang | Steadicam Operator |
| Camera | Alec Jarnagin | Steadicam Operator |
| Camera | Nicole Rivelli | Still Photographer |
| Camera | Brent Poleski | Key Grip |
| Camera | Larhn Laurens Davitt | Dolly Grip |
| Camera | Nuno Oliveira | Grip |
| Camera | Cliff Alphonse | Grip |
| Camera | Parissh McClean | Grip |
| Camera | Anthony F. Gamiello | Grip |
| Camera | Sally Foster | Grip |
| Art | Elizabeth Rodrick | Set Decoration |
| Art | Jack Mortellaro Jr. | Leadman |
| Art | Bill C. Bishop | Leadman |
| Art | Anthony Taratunio | Set Dresser |
| Costume & Make-Up | Maeve Kelly | Assistant Costume Designer |
| Costume & Make-Up | Christina Nickas | Wardrobe Supervisor |
| Costume & Make-Up | Megan Sanders | Wardrobe Supervisor |
| Costume & Make-Up | Lauren Colbert | Costume Coordinator |
| Lighting | Jason Velez | Gaffer |
| Lighting | Francesco Pinna | Best Boy Electric |
| Art | Andy Eklund | Art Direction |
| Art | Shane Aitchison | Art Department Coordinator |
| Art | Richard Hebrank | Construction Coordinator |
| Art | Anthony S. Calypso | Assistant Property Master |
| Crew | Jeff Brink | Special Effects Coordinator |
| Costume & Make-Up | Leo Won | Makeup Department Head |
| Costume & Make-Up | Kirsten Sylvester | Key Makeup Artist |
| Costume & Make-Up | Raquel Vivve | Makeup Artist |
| Production | Cynthia Chou | Production Coordinator |
| Production | Nicki Slack | Assistant Production Coordinator |
| Crew | Jocelyn Magsumbol | Production Office Assistant |
| Crew | Roberto González Arévalo | Production Office Assistant |
| Production | Jillian Stricker | Location Manager |
| Sound | Jerry 'Niru' Cox | Boom Operator |
| Sound | Paul Reed | Utility Sound |
| Sound | Junior Cyrus Baron | Utility Sound |
| Costume & Make-Up | Tonia Ciccone | Hair Department Head |
| Costume & Make-Up | Toni Roman-Grimm | Key Hair Stylist |
| Costume & Make-Up | Josh Gericke | Hairstylist |
| Costume & Make-Up | Bert Reo Anderson | Hairstylist |
| Production | Johnny Holland | Production Accountant |
| Crew | Brad Gage | Actor's Assistant |
| Crew | Adrienne Enderle | Set Production Assistant |
| Crew | Matthew McCoubry | Set Production Assistant |
| Crew | Matt Merksamer | Set Production Assistant |
| Crew | Anthony Pennachio | Set Production Assistant |
| Crew | Jon Santos | Set Production Assistant |
| Crew | Alex Lilja | Set Production Assistant |
| Crew | Alex Spear | Set Production Assistant |
| Crew | Jasmine Brotzman | Set Production Assistant |
| Crew | Liz Wagner | Set Production Assistant |
| Crew | Robert Maasin | Set Production Assistant |
| Crew | Yadeed Mellman | Set Production Assistant |
| Crew | Ava Myint | Set Production Intern |
| Crew | Lauren Meckleberg | Set Production Intern |
| Crew | Isaac Gotterer | Set Production Intern |
| Crew | Ella Gibney | Set Production Intern |
| Production | Allison Kirschner | Casting Associate |
| Production | Nicole P. Hearon | Casting Associate |
| Production | Aaron Schoonover | Casting Associate |
| Crew | George Holtzer | Transportation Captain |
| Crew | Peter Link | Driver |
| Crew | Bob Papini Jr. | Driver |
| Crew | Damon Tragni | Driver |
| Crew | PJ Ford | Driver |
| Crew | Ryan Murphy | Driver |
| Crew | Ed Elliot | Driver |
| Crew | Mike Devereaux | Driver |
| Crew | Mike McElroy | Driver |
| Crew | Mike Murphy | Driver |
| Crew | Michael Jackman | Post Production Supervisor |
| Editing | Luis Cuevas | Assistant Editor |
| Editing | Leah Tuscano | Assistant Editor |
| Sound | Tom Paul | Supervising Sound Editor |
| Sound | Bobby Mackston | Sound Editor |
| Sound | Dan Edelstein | ADR Editor |
| Sound | Sean Garnhart | Sound Effects Editor |
| Sound | Pam DeMetruis-Thomas | Foley Editor |
| Sound | Tom Paul | Sound Re-Recording Mixer |
| Sound | Mark Linden | Sound Re-Recording Mixer |
| Production | Dann Fink | ADR Voice Casting |
| Production | Bruce Winant | ADR Voice Casting |
| Sound | Azniv Korkejian | Music Editor |
| Visual Effects | Lucien Harriot | VFX Supervisor |
| Visual Effects | Fangge Chen | Digital Compositors |
| Visual Effects | Constance Conrad | Digital Compositors |
| Visual Effects | Saffia Rahimtoola | Digital Compositors |
| Visual Effects | Melissa Kivell | VFX Production Coordinator |
| Production | Adam Kersh | Publicist |
| Art | Aaron Becker | Title Designer |
| Sound | Bill Orrico | Dialogue Editor |
| Sound | Charles R. Hunt | Production Sound Mixer |
| Editing | Zach Wolf | Assistant Editor |
| Crew | Michael Elliott | Transportation Co-Captain |
| Crew | Dave Kloc | Thanks |
| Crew | Dana Gould | Thanks |
| Crew | Nicole Eckenroad | Thanks |
| Crew | Moshe Kasher | Thanks |
| Crew | Alec Berg | Thanks |
| Crew | Chuck Schumer | Thanks |
| Crew | Christine Nangle | Thanks |
| Crew | Lisa Goldberg | Thanks |
| Crew | Dominic Dierkes | Thanks |
| Crew | Sean Clements | Thanks |
| Crew | Casey Shaw | Thanks |
| Crew | Krister C. Johnson | Thanks |
| Crew | Jared Logan | Thanks |
| Crew | Pete Holmes | Thanks |
| Crew | James Gunn | Thanks |
| Crew | Emily Heller | Thanks |
| Crew | Glenn D. Feig | Legal Services |
| Crew | Noor Ahmed | Legal Services |
| Crew | Joshua Shabani | Legal Services |
| Crew | Brady Smoot | Legal Services |
| Crew | Dr. Jonathan Foster | Medical Consultant |
| Production | Rachel Schneider | Post Production Accountant |
| Visual Effects | Neal Jonas | Visual Effects |
| Sound | Todd Burke | Scoring Mixer |
| Sound | Sebastian Henshaw | Foley Artist |
| Sound | Carl Shillito | Foley Mixer |
| Camera | Keith Gordon | Best Boy Grip |
| Camera | Connor Dwyer | Best Boy Grip |
| Camera | Chris Keenan | Grip |
| Directing | Scott Bowers | Second Second Assistant Director |
| Camera | Ari Issler | "A" Camera Operator |
| Camera | Andrew Juhl | First Assistant "A" Camera |
| Camera | Blake Johnson | Second Assistant "A" Camera |
| Camera | Frank Larson | "B" Camera Operator |
| Camera | Pierrot Colonna | "B" Camera Operator |
| Camera | Htat Htut | First Assistant "B" Camera |
| Camera | Fillip Penson | First Assistant "B" Camera |
| Camera | Casey David Johnson | Second Assistant "B" Camera |
| Camera | Ashton Green | Second Assistant "B" Camera |
| Crew | Matt Harding | Loader |
| Costume & Make-Up | Nicole Capogna | Costumer |
| Costume & Make-Up | Eva Marie Lopez | Costumer |
| Costume & Make-Up | Ismyrne Geffrard | Costumer |
| Costume & Make-Up | Ember Roth | Costumer |
| Art | Scott Griswold | Set Dressing Buyer |
| Costume & Make-Up | Gregor Telfer | On Set Dresser |
| Costume & Make-Up | Andrew Schoentube | On Set Dresser |
| Sound | Paul Reed | Utility Sound |
| Costume & Make-Up | Isabelle Decauwert | Additional Hairstylist |
| Production | Brittany Sugarman | First Assistant Accountant |
| Production | Gabriel Gonzalez | Assistant Location Manager |
| Production | Michael L. Mizrahi | Assistant Location Manager |
| Production | Adam Williams | Location Assistant |
| Production | Sharmain Perry | Location Assistant |
| Crew | Alcy Sivyer | Assistant Craft Service |
| Crew | Wendy Cohen | Clearances Consultant |
| Crew | Stanley D. Burns | Medical Consultant |
| Crew | Liz Burns | Medical Consultant |
| Crew | France Iann | Medical Consultant |
| Crew | Susan Millard | Medical Consultant |
| Production | Carol A. Compton | Script Researcher |
| Crew | Umberto Ramero | Catering |
| Crew | Rich Elmiler | Catering |
| Crew | Brian Havens | Catering |
| Crew | Alvero Castillo | Catering |
| Crew | Rich Alfieri | Catering |
| Crew | Jorge Ramirez | Catering |
| Crew | Eric Vidomouels | Catering |
| Crew | John Lee | Catering |
| Production | Sam Fishell | Producer's Assistant |
| Production | Ryan Bernstein | Producer's Assistant |
| Production | Leigh Pruden | Producer's Assistant |
| Production | Hannah Getts | Executive Producer's Assistant |
| Editing | Alex Bickel | Digital Intermediate Colorist |
| Editing | Andrew McKay | Digital Intermediate Producer |
| Editing | Claudia Guevara | Digital Intermediate Producer |
| Editing | Sean R. Smith | Digital Conform Editor |
