Kal Ho Naa Ho vertelt het verhaal van de drie, in New York wonende, vrienden Aman, Rohit en Naina. De essentie van ware vriendschap en het omgaan met geluk en verdriet staan centraal in het verhaal.
| Editing | Sanjay Sankla | Editor |
| Production | Yash Johar | Producer |
| Camera | Anil Mehta | Director of Photography |
| Production | Karan Johar | Producer |
| Art | Sharmishta Roy | Production Design |
| Writing | Karan Johar | Screenplay |
| Directing | Nikkhil Advani | Director |
| Writing | Karan Johar | Story |
| Directing | Mamta Anand | Assistant Director |
| Production | Ganesh Nankoosingh | Line Producer |
| Production | Gopal Babel | Production Manager |
| Sound | Anuj Mathur | Sound Assistant |
| Directing | Tarun Mansukhani | First Assistant Director |
| Directing | Arjun Kapoor | Assistant Director |
| Directing | Punit Malhotra | Assistant Director |
| Production | Manoj Mittra | Production Executive |
| Directing | Shiraz Siddique | Assistant Director |
| Directing | Ana Cuadra | First Assistant Director |
| Writing | Niranjan Iyengar | Dialogue |
| Directing | David Coombs | First Assistant Director |
| Sound | Shankar Singh Raghuvanshi | Sound Editor |
| Production | Prashant Kunder | Production Manager |
| Production | Sean Powers | Casting Director |
| Costume & Make-Up | Manish Malhotra | Costume Design |
| Costume & Make-Up | Mickey Contractor | Makeup Artist |
| Directing | Kapil Chopra | Assistant Director |
| Crew | Imtiaz Ansari | Production Controller |
| Crew | Rashid Abbasi | Production Controller |
| Sound | Ajay Kumar P. B. | Location Sound Recordist |
| Crew | Farah Khan | Choreographer |
| Production | Fabio Martinez | Location Manager |
| Production | Joseph White | Location Manager |
| Production | Malaika Johnson | Location Manager |
| Art | Mohammed Kasam Sayyad | Assistant Art Director |
| Production | Rita Powers | Casting Director |
| Sound | Shankar Mahadevan | Original Music Composer |
| Production | Anadil Hossain | Line Producer |
| Production | Driss Benyaklef | Production Manager |
| Sound | Ehsaan Noorani | Original Music Composer |
| Sound | Vikram Biswas | Foley Artist |
| Production | Alex Schimel | Production Executive |
| Sound | Anuj Mathur | Sound Designer |
| Visual Effects | Pankaj Khandpur | Visual Effects |
| Production | Hiroo Johar | Associate Producer |
| Sound | Loy Mendonsa | Original Music Composer |
| Sound | Parikshit Lalwani | Sound Editor |
| Sound | Kuldip Sood | Location Sound Recordist |
| Sound | Ali Merchant | Sound Editor |
| Sound | Kunal Uday Mehta | Sound Editor |
| Sound | Prashant Nayar | Sound Re-Recording Mixer |
| Sound | Sonu Nigam | Playback Singer |
| Sound | Alka Yagnik | Playback Singer |
| Sound | Vasundhara Das | Playback Singer |
| Sound | Sadhana Sargam | Playback Singer |
| Sound | Shankar Mahadevan | Playback Singer |
| Sound | Udit Narayan | Playback Singer |
| Sound | KK | Playback Singer |
| Sound | Richa Sharma | Playback Singer |
