Kal Ho Naa Ho vertelt het verhaal van de drie, in New York wonende, vrienden Aman, Rohit en Naina. De essentie van ware vriendschap en het omgaan met geluk en verdriet staan centraal in het verhaal.
| Writing | Karan Johar | Screenplay |
| Directing | Nikkhil Advani | Director |
| Production | Yash Johar | Producer |
| Art | Sharmishta Roy | Production Design |
| Production | Karan Johar | Producer |
| Editing | Sanjay Sankla | Editor |
| Camera | Anil Mehta | Director of Photography |
| Writing | Karan Johar | Story |
| Directing | Mamta Anand | Assistant Director |
| Directing | Punit Malhotra | Assistant Director |
| Directing | Arjun Kapoor | Assistant Director |
| Crew | Imtiaz Ansari | Production Controller |
| Visual Effects | Pankaj Khandpur | Visual Effects |
| Directing | Kapil Chopra | Assistant Director |
| Production | Manoj Mittra | Production Executive |
| Art | Mohammed Kasam Sayyad | Assistant Art Director |
| Production | Fabio Martinez | Location Manager |
| Production | Joseph White | Location Manager |
| Directing | Ana Cuadra | First Assistant Director |
| Directing | David Coombs | First Assistant Director |
| Production | Hiroo Johar | Associate Producer |
| Production | Sean Powers | Casting Director |
| Sound | Loy Mendonsa | Original Music Composer |
| Sound | Shankar Singh Raghuvanshi | Sound Editor |
| Production | Rita Powers | Casting Director |
| Writing | Niranjan Iyengar | Dialogue |
| Sound | Anuj Mathur | Sound Designer |
| Sound | Ali Merchant | Sound Editor |
| Crew | Farah Khan | Choreographer |
| Directing | Shiraz Siddique | Assistant Director |
| Production | Alex Schimel | Production Executive |
| Sound | Ajay Kumar P. B. | Location Sound Recordist |
| Production | Gopal Babel | Production Manager |
| Sound | Parikshit Lalwani | Sound Editor |
| Sound | Anuj Mathur | Sound Assistant |
| Directing | Tarun Mansukhani | First Assistant Director |
| Production | Ganesh Nankoosingh | Line Producer |
| Production | Prashant Kunder | Production Manager |
| Crew | Rashid Abbasi | Production Controller |
| Costume & Make-Up | Manish Malhotra | Costume Design |
| Production | Malaika Johnson | Location Manager |
| Production | Driss Benyaklef | Production Manager |
| Sound | Shankar Mahadevan | Original Music Composer |
| Production | Anadil Hossain | Line Producer |
| Costume & Make-Up | Mickey Contractor | Makeup Artist |
| Sound | Ehsaan Noorani | Original Music Composer |
| Sound | Kuldip Sood | Location Sound Recordist |
| Sound | Kunal Uday Mehta | Sound Editor |
| Sound | Vikram Biswas | Foley Artist |
| Sound | Prashant Nayar | Sound Re-Recording Mixer |
| Sound | Sonu Nigam | Playback Singer |
| Sound | Alka Yagnik | Playback Singer |
| Sound | Vasundhara Das | Playback Singer |
| Sound | Sadhana Sargam | Playback Singer |
| Sound | Shankar Mahadevan | Playback Singer |
| Sound | Udit Narayan | Playback Singer |
| Sound | KK | Playback Singer |
| Sound | Richa Sharma | Playback Singer |
