Dr. Misty Calhoun wordt gevraagd mee te werken aan een topgeheim experiment. Tijdens het experiment zullen haaien genetisch gemanipuleerd worden in een laboratorium onder water. Aan het hoofd staat Carl Durant, een miljardair die zijn vermogen verdiend heeft met medicijnen.
Nee, helaas is Deep Blue Sea 2 nog niet beschikbaar op Netflix in Nederland.
| Writing | Donna Powers | Characters |
| Writing | Duncan Kennedy | Characters |
| Writing | Wayne Powers | Characters |
| Production | Riaan Cordier | Production Accountant |
| Visual Effects | Hein Oosthuizen | 3D Artist |
| Costume & Make-Up | Carren Marchant | Costume Standby |
| Editing | Kyle Landman | Dailies Operator |
| Production | Mayra Garcia | Production Coordinator |
| Editing | Christopher Obal | Digital Intermediate Editor |
| Production | Shannyn Zorab | Production Assistant |
| Lighting | Gilles Boisacq | Gaffer |
| Directing | Darin Scott | Director |
| Camera | Thomas L. Callaway | Director of Photography |
| Art | Franz Lewis | Production Design |
| Editing | Michael Trent | Editor |
| Production | David Wicht | Co-Producer |
| Writing | Hans Rodionoff | Story |
| Sound | Sean Murray | Original Music Composer |
| Production | Tom Keniston | Executive Producer |
| Production | Harriet Greenspan | Casting |
| Production | Tom Siegrist | Producer |
| Camera | Jonathan Kyle | Focus Puller |
| Lighting | Julius Ndakwa | Electrician |
| Visual Effects | Christopher Bekker | Digital Compositor |
| Visual Effects | David Jose Ferreira | Digital Compositor |
| Crew | Maria Friesen | Visual Effects Editor |
| Camera | Zaheer Ismail | Grip |
| Camera | Brendon Bennett | Underwater Camera |
| Production | Craig Swanepoel | Extras Casting |
| Production | Johan van Huyssteen | Location Manager |
| Crew | Sven Hohmeier | Compositor |
| Sound | Christopher M. Foster | Music Editor |
| Art | Mark Risk | Storyboard Artist |
| Sound | Jason Oliver | ADR Mixer |
| Sound | Fred Paragano | Sound Re-Recording Mixer |
| Crew | Dylan Palmboom | Compositor |
| Visual Effects | Carelize Jacobs | Digital Compositor |
| Camera | Damien Walsh | Focus Puller |
| Crew | Lise-Marie Bothma | Special Effects Coordinator |
| Camera | Sven Vosloo | "A" Camera Operator |
| Camera | Adrian Boerlage | First Assistant Camera |
| Crew | Fraser James | Marine Coordinator |
| Sound | Barry Donnelly | ADR Recordist |
| Sound | Travis Crotts | Foley Editor |
| Editing | Bruce Lomet | Digital Intermediate Producer |
| Crew | Darrin Hofmeyr | CG Supervisor |
| Visual Effects | Mathapo Tlou | Digital Compositor |
| Camera | Guy Hodgen | "B" Camera Operator |
| Camera | Jason Venter | Best Boy Grip |
| Camera | Casey van der Touw | Camera Loader |
| Lighting | Moses Makateng | Electrician |
| Sound | Clayton Weber | Supervising Sound Editor |
| Camera | Anele Thobi | Assistant Grip |
| Camera | Mark Forster | Key Grip |
| Costume & Make-Up | Juanette Van Der Merwe | Key Makeup Artist |
| Camera | Roderick Dean Smith | Key Grip |
| Camera | Jan Du Toit | Epk Camera Operator |
| Crew | Norman Jardim | Carpenter |
| Art | Hugo Queiroga | Construction Manager |
| Sound | Travis Crotts | Dialogue Editor |
| Visual Effects | Byron Tofas | Compositing Lead |
| Camera | Lwazi Jokazi | Assistant Grip |
| Lighting | Justice Amadi | Electrician |
| Art | Shakeela Kingzley | Art Department Coordinator |
| Camera | Sven Vosloo | Second Unit Director of Photography |
| Lighting | Guy Stallard | Gaffer |
| Editing | Matt McFarland | Digital Intermediate Colorist |
| Crew | Stephanie Traut | Visual Effects Editor |
| Visual Effects | Marc Bloch | Visual Effects Supervisor |
| Directing | Ashley Aldworth | Script Supervisor |
| Crew | Helene Turvey | Unit Publicist |
| Visual Effects | Annel Rautenbach | Digital Compositor |
| Visual Effects | Tyla Koen | Digital Compositor |
| Visual Effects | Douw van Niekerk | Digital Compositor |
| Costume & Make-Up | Misha du Toit | Costume Supervisor |
| Directing | Andre Weavind | First Assistant Director |
| Sound | Claire Hesom | Boom Operator |
| Visual Effects | Marco Raposo de Barbosa | Visual Effects Supervisor |
| Camera | Riyaad Majiet | Best Boy Grip |
| Camera | Wayne Richards | Grip |
| Writing | Hans Rodionoff | Teleplay |
| Writing | Erik Patterson | Teleplay |
| Writing | Jessica Scott | Teleplay |
| Costume & Make-Up | Niqui da Silva | Makeup Designer |
| Sound | Clayton Weber | Sound Re-Recording Mixer |
| Visual Effects | Max Poolman | Special Effects Supervisor |
| Crew | Angelo Beceiro Collinicos | Compositor |
| Camera | Ezra Van Schalkwyk | Camera Loader |
| Camera | Nigel Tompkins | Digital Imaging Technician |
| Costume & Make-Up | Dihantus Engelbrecht | Costume Design |
| Sound | Kurt Godwin | Sound Mix Technician |
