Enola Holmes, de jongere zus van Sherlock en Mycroft, wordt in de negentiende eeuw door haar excentrieke moeder Eudoria opgevoed. Wanneer haar moeder op haar zestiende verjaardag spoorloos verdwijnt, vindt Enola verborgen aanwijzingen die haar moeder heeft achtergelaten. Om haar zoektocht te vergemakkelijken, geeft Enola zich uit voor een man en trekt ze naar Londen.
| Art | Matt Curtis | Title Designer |
| Crew | Tom Hannibal | Visual Effects Editor |
| Visual Effects | Pratik Chaudhari | Visual Effects |
| Sound | Markus Andreas | Sound Assistant |
| Writing | Arthur Conan Doyle | Characters |
| Production | Millie Bobby Brown | Producer |
| Writing | Nancy Springer | Novel |
| Writing | Jack Thorne | Screenplay |
| Directing | Harry Bradbeer | Director |
| Production | Paige Brown | Producer |
| Editing | Adam Bosman | Editor |
| Production | Jina Jay | Casting |
| Art | Michael Carlin | Production Design |
| Costume & Make-Up | Consolata Boyle | Costume Design |
| Production | Michael Dreyer | Executive Producer |
| Production | Ali Mendes | Producer |
| Production | Harry Bradbeer | Executive Producer |
| Camera | Giles Nuttgens | Director of Photography |
| Production | Mary Parent | Producer |
| Production | Michael Dreyer | Unit Production Manager |
| Directing | Jack Ravenscroft | First Assistant Director |
| Production | Simon Fraser | Unit Production Manager |
| Sound | Daniel Pemberton | Original Music Composer |
| Production | Alex Garcia | Producer |
| Directing | Joe Barlow | Second Assistant Director |
| Production | Joshua Grode | Executive Producer |
| Production | Jane Houston | Co-Producer |
| Crew | Jo McLaren | Stunt Coordinator |
| Crew | Juliette Cheveley | Stunt Double |
| Crew | Ian Pead | Fight Choreographer |
| Crew | Fizz Hood | Stunt Double |
| Crew | Hasit Savani | Stunt Double |
| Crew | Matthew Bell | Stunts |
| Art | Ashley Winter | Art Direction |
| Art | Choi Ho Man | Supervising Art Director |
| Crew | Nicholas Daines | Stunts |
| Crew | Kim McGarrity | Stunts |
| Crew | Ruth Nelson | Stunts |
| Crew | Will Deville | Stunts |
| Crew | Nadia Hansell | Stunts |
| Crew | Shane Roberts | Stunts |
| Art | Martin Hitchcock | Art Direction |
| Art | Andrew Munro | Art Direction |
| Crew | Nina Armstrong | Stunts |
| Crew | Liam Coote | Stunts |
| Crew | James O'Daly | Stunts |
| Camera | Paul Edwards | Steadicam Operator |
| Art | Suzanna Smith | Assistant Art Director |
| Lighting | Dave Thom | Best Boy Electric |
| Costume & Make-Up | Sian Grigg | Hair Designer |
| Camera | Ray Meere | First Assistant "A" Camera |
| Crew | Chus Lucas | Stunts |
| Crew | Marlow Warrington-Mattei | Stunts |
| Crew | Sarah Lochlan | Stunts |
| Crew | Adrian McGaw | Stunts |
| Crew | Luke Scott | Stunts |
| Camera | Spencer Murray | First Assistant "B" Camera |
| Camera | Adam Shell | Digital Imaging Technician |
| Directing | Jane Houston | Script Supervisor |
| Camera | Alex Bailey | Still Photographer |
| Art | Lisa Chugg | Set Decoration |
| Camera | Paul Edwards | "B" Camera Operator |
| Lighting | Andy Cole | Gaffer |
| Camera | Harry Wingate | Second Assistant "A" Camera |
| Crew | Alli Ryan | Stunts |
| Camera | Giles Nuttgens | "A" Camera Operator |
| Sound | Will Whale | Production Sound Mixer |
| Crew | Annabel Wood | Stunts |
| Costume & Make-Up | Sian Grigg | Makeup Designer |
| Art | Lorna Houlihan | Assistant Art Director |
| Camera | Alistair King | Second Assistant "B" Camera |
| Lighting | Alan Graham | Rigging Gaffer |
| Visual Effects | Mark Holt | Special Effects Supervisor |
| Crew | Aimee Watret | Special Effects Coordinator |
| Costume & Make-Up | Bethany Cross | Costume Coordinator |
| Art | Roy Chapman | Property Master |
| Production | Jess MacDonald | Location Manager |
| Costume & Make-Up | Joanne Lees | Assistant Costume Designer |
| Camera | Bernd Mayer | Key Grip |
| Costume & Make-Up | Marion Weise | Costume Supervisor |
| Costume & Make-Up | Carol Hemming | Hairstylist |
| Editing | Emanuele Giraldo | First Assistant Editor |
| Costume & Make-Up | Sarah Nuth | Makeup & Hair |
| Production | Fiona Harper | Production Coordinator |
| Crew | Emma Zee | Post Production Supervisor |
| Costume & Make-Up | Claudia Stolze | Makeup & Hair |
| Production | Chris Bevan | Assistant Production Coordinator |
| Visual Effects | Helen Judd | Visual Effects Producer |
| Sound | Dario Swade | Foley Editor |
| Visual Effects | Michael Bruce Ellis | Visual Effects Supervisor |
| Production | Eleanor Coverdale | Assistant Production Coordinator |
| Production | Olivia Brittain | Casting Associate |
| Sound | Ben Smithers | Music Editor |
| Sound | Oliver Ferris | Foley Artist |
| Sound | Maria Kelly | ADR Recordist |
| Crew | David Beminster | Transportation Captain |
| Sound | Alison Litton | Music Supervisor |
| Production | Nessa King | Production Accountant |
| Sound | Amy Felton | Dialogue Editor |
| Sound | Sophia Hardman | Foley Mixer |
| Visual Effects | Catherine Hébert | Visual Effects Supervisor |
| Production | Catherine Garlick | Casting Assistant |
| Sound | Eilam Hoffman | Supervising Sound Editor |
| Sound | Samir Fočo | Sound Designer |
| Sound | Andrew Skeet | Orchestrator |
| Sound | Sue Harding | Foley Artist |
| Art | Warren Lever | Construction Manager |
| Sound | Peter Afterman | Music Supervisor |
| Sound | Jane Berry | Music Coordinator |
| Art | Jools Faiers | Graphic Designer |
| Crew | Mason Durrell | Transportation Co-Captain |
| Camera | Peter Talbot | Second Unit Director of Photography |
| Crew | Rob Harris | Unit Publicist |
| Sound | Louise Burton | Assistant Sound Editor |
| Art | Amandeep Rahi | Set Decoration Buyer |
| Sound | Nina Hartstone | Supervising Sound Editor |
| Sound | Steve Browell | Sound Effects Editor |
| Art | Sian Lyn-Jones | Construction Coordinator |
| Crew | Rachel Bucknor | Unit Medic |
| Sound | Mike Tehrani | ADR Mixer |
| Production | Rebecca Rossmaur | Casting Assistant |
| Sound | Jens Rosenlund Petersen | Supervising Dialogue Editor |
| Art | Molly Blake | Art Department Coordinator |
| Crew | Nicola Graydon-Harris | Unit Publicist |
| Crew | Penny Dyer | Dialect Coach |
| Sound | Andrew Skeet | Conductor |
| Production | Valentina König | Assistant Production Coordinator |
| Art | Sav Akyüz | Storyboard Artist |
| Production | Verity Naughton | Additional Casting |
| Production | Harry Skinner | Payroll Accountant |
| Sound | Tom Sayers | Sound Designer |
