Enola Holmes, de jongere zus van Sherlock en Mycroft, wordt in de negentiende eeuw door haar excentrieke moeder Eudoria opgevoed. Wanneer haar moeder op haar zestiende verjaardag spoorloos verdwijnt, vindt Enola verborgen aanwijzingen die haar moeder heeft achtergelaten. Om haar zoektocht te vergemakkelijken, geeft Enola zich uit voor een man en trekt ze naar Londen.
| Art | Matt Curtis | Title Designer |
| Crew | Tom Hannibal | Visual Effects Editor |
| Visual Effects | Pratik Chaudhari | Visual Effects |
| Sound | Markus Andreas | Sound Assistant |
| Writing | Arthur Conan Doyle | Characters |
| Production | Millie Bobby Brown | Producer |
| Writing | Nancy Springer | Novel |
| Directing | Harry Bradbeer | Director |
| Writing | Jack Thorne | Screenplay |
| Production | Paige Brown | Producer |
| Production | Michael Dreyer | Executive Producer |
| Editing | Adam Bosman | Editor |
| Production | Jina Jay | Casting |
| Art | Michael Carlin | Production Design |
| Costume & Make-Up | Consolata Boyle | Costume Design |
| Sound | Daniel Pemberton | Original Music Composer |
| Production | Mary Parent | Producer |
| Production | Ali Mendes | Producer |
| Production | Alex Garcia | Producer |
| Production | Joshua Grode | Executive Producer |
| Production | Harry Bradbeer | Executive Producer |
| Camera | Giles Nuttgens | Director of Photography |
| Production | Michael Dreyer | Unit Production Manager |
| Production | Simon Fraser | Unit Production Manager |
| Directing | Jack Ravenscroft | First Assistant Director |
| Directing | Joe Barlow | Second Assistant Director |
| Production | Jane Houston | Co-Producer |
| Crew | Jo McLaren | Stunt Coordinator |
| Crew | Fizz Hood | Stunt Double |
| Crew | Hasit Savani | Stunt Double |
| Crew | Juliette Cheveley | Stunt Double |
| Crew | Ian Pead | Fight Choreographer |
| Art | Choi Ho Man | Supervising Art Director |
| Art | Martin Hitchcock | Art Direction |
| Art | Andrew Munro | Art Direction |
| Art | Ashley Winter | Art Direction |
| Crew | Nina Armstrong | Stunts |
| Crew | Matthew Bell | Stunts |
| Crew | Liam Coote | Stunts |
| Crew | Nicholas Daines | Stunts |
| Crew | Will Deville | Stunts |
| Crew | Nadia Hansell | Stunts |
| Crew | Sarah Lochlan | Stunts |
| Crew | Chus Lucas | Stunts |
| Crew | Kim McGarrity | Stunts |
| Crew | Adrian McGaw | Stunts |
| Crew | Ruth Nelson | Stunts |
| Crew | James O'Daly | Stunts |
| Crew | Shane Roberts | Stunts |
| Crew | Alli Ryan | Stunts |
| Crew | Luke Scott | Stunts |
| Crew | Marlow Warrington-Mattei | Stunts |
| Crew | Annabel Wood | Stunts |
| Camera | Giles Nuttgens | "A" Camera Operator |
| Art | Lisa Chugg | Set Decoration |
| Art | Lorna Houlihan | Assistant Art Director |
| Art | Suzanna Smith | Assistant Art Director |
| Camera | Paul Edwards | Steadicam Operator |
| Camera | Paul Edwards | "B" Camera Operator |
| Camera | Ray Meere | First Assistant "A" Camera |
| Camera | Harry Wingate | Second Assistant "A" Camera |
| Camera | Spencer Murray | First Assistant "B" Camera |
| Camera | Alistair King | Second Assistant "B" Camera |
| Camera | Adam Shell | Digital Imaging Technician |
| Camera | Alex Bailey | Still Photographer |
| Directing | Jane Houston | Script Supervisor |
| Sound | Will Whale | Production Sound Mixer |
| Lighting | Andy Cole | Gaffer |
| Lighting | Dave Thom | Best Boy Electric |
| Lighting | Alan Graham | Rigging Gaffer |
| Camera | Bernd Mayer | Key Grip |
| Visual Effects | Mark Holt | Special Effects Supervisor |
| Crew | Aimee Watret | Special Effects Coordinator |
| Production | Jess MacDonald | Location Manager |
| Art | Roy Chapman | Property Master |
| Costume & Make-Up | Marion Weise | Costume Supervisor |
| Costume & Make-Up | Joanne Lees | Assistant Costume Designer |
| Costume & Make-Up | Bethany Cross | Costume Coordinator |
| Costume & Make-Up | Sian Grigg | Hair Designer |
| Costume & Make-Up | Sian Grigg | Makeup Designer |
| Costume & Make-Up | Carol Hemming | Hairstylist |
| Costume & Make-Up | Sarah Nuth | Makeup & Hair |
| Costume & Make-Up | Claudia Stolze | Makeup & Hair |
| Editing | Emanuele Giraldo | First Assistant Editor |
| Crew | Emma Zee | Post Production Supervisor |
| Visual Effects | Helen Judd | Visual Effects Producer |
| Visual Effects | Michael Bruce Ellis | Visual Effects Supervisor |
| Production | Fiona Harper | Production Coordinator |
| Production | Valentina König | Assistant Production Coordinator |
| Production | Chris Bevan | Assistant Production Coordinator |
| Production | Eleanor Coverdale | Assistant Production Coordinator |
| Art | Jools Faiers | Graphic Designer |
| Art | Sav Akyüz | Storyboard Artist |
| Art | Molly Blake | Art Department Coordinator |
| Art | Amandeep Rahi | Set Decoration Buyer |
| Production | Olivia Brittain | Casting Associate |
| Production | Rebecca Rossmaur | Casting Assistant |
| Production | Catherine Garlick | Casting Assistant |
| Production | Verity Naughton | Additional Casting |
| Crew | Penny Dyer | Dialect Coach |
| Crew | Nicola Graydon-Harris | Unit Publicist |
| Crew | Rob Harris | Unit Publicist |
| Production | Nessa King | Production Accountant |
| Production | Harry Skinner | Payroll Accountant |
| Sound | Nina Hartstone | Supervising Sound Editor |
| Sound | Eilam Hoffman | Supervising Sound Editor |
| Sound | Jens Rosenlund Petersen | Supervising Dialogue Editor |
| Sound | Amy Felton | Dialogue Editor |
| Sound | Samir Fočo | Sound Designer |
| Sound | Tom Sayers | Sound Designer |
| Sound | Steve Browell | Sound Effects Editor |
| Sound | Louise Burton | Assistant Sound Editor |
| Sound | Mike Tehrani | ADR Mixer |
| Sound | Sue Harding | Foley Artist |
| Sound | Oliver Ferris | Foley Artist |
| Sound | Sophia Hardman | Foley Mixer |
| Sound | Dario Swade | Foley Editor |
| Sound | Maria Kelly | ADR Recordist |
| Art | Warren Lever | Construction Manager |
| Art | Sian Lyn-Jones | Construction Coordinator |
| Crew | David Beminster | Transportation Captain |
| Crew | Mason Durrell | Transportation Co-Captain |
| Crew | Rachel Bucknor | Unit Medic |
| Camera | Peter Talbot | Second Unit Director of Photography |
| Sound | Alison Litton | Music Supervisor |
| Sound | Peter Afterman | Music Supervisor |
| Sound | Jane Berry | Music Coordinator |
| Sound | Andrew Skeet | Orchestrator |
| Sound | Andrew Skeet | Conductor |
| Sound | Ben Smithers | Music Editor |
| Visual Effects | Catherine Hébert | Visual Effects Supervisor |
