John Rambo is met pensioen en woont op een boerderij in de Verenigde Staten. Op een dag hoort hij van Maria, een oude familievriendin en vastgoedmanager, dat zijn dochter is ontvoerd door een Mexicaans drugskartel. Al snel komt John terecht in de gewelddadige wereld van de sekshandel. Hij werkt samen met een journalist, wiens halfzus ook is ontvoerd, en moet al zijn vaardigheden inzetten om de meisjes te redden en een kwaadaardige misdaadbaas neer te halen.
Nee, helaas is Rambo: Last Blood nog niet beschikbaar op Netflix in Nederland.
| Crew | Dessy Slavova | Stunt Double |
| Crew | Radka Petkova | Stunts |
| Writing | Matthew Cirulnick | Screenplay |
| Production | Avi Lerner | Producer |
| Writing | Sylvester Stallone | Screenplay |
| Production | Kevin King Templeton | Producer |
| Production | Ariel Vromen | Executive Producer |
| Production | Christa Campbell | Executive Producer |
| Production | Lati Grobman | Executive Producer |
| Directing | Adrian Grünberg | Director |
| Art | David Temprano | Art Direction |
| Sound | Vladimir Kaloyanov | Sound Mixer |
| Art | Eduardo Hidalgo Jr. | Art Direction |
| Art | Franco-Giacomo Carbone | Production Design |
| Sound | Ryan Nowak | Sound Designer |
| Sound | Kiril Kaloyanov | Boom Operator |
| Writing | David Morrell | Characters |
| Editing | Todd E. Miller | Editor |
| Sound | Brian Tyler | Original Music Composer |
| Camera | Brendan Galvin | Director of Photography |
| Editing | Carsten Kurpanek | Editor |
| Production | Louis Arriola | Executive Producer |
| Production | Allen Dam | Executive Producer |
| Costume & Make-Up | Cristina Sopeña | Costume Designer |
| Production | Jonathan Yunger | Executive Producer |
| Production | Les Weldon | Producer |
| Production | Elijah Long | Co-Executive Producer |
| Production | Robert Van Norden | Executive Producer |
| Production | Jiewen Tan | Executive Producer |
| Production | Boaz Davidson | Executive Producer |
| Production | Damaine Radcliff | Co-Executive Producer |
| Production | Samuel Hadida | Co-Executive Producer |
| Production | Yariv Lerner | Producer |
| Production | Victor Hadida | Co-Executive Producer |
| Production | Zhang Qun | Executive Producer |
| Production | Jeff Gum | Executive Producer |
| Production | Jeffrey Greenstein | Executive Producer |
| Production | Liu Rong | Executive Producer |
| Production | Carla Hool | Casting |
| Production | Matthew O'Toole | Executive Producer |
| Camera | Miroslav Borisov | Key Grip |
| Production | Valentin Dimitrov | Line Producer |
| Crew | Georgi Manchev | Fight Choreographer |
| Crew | Cuco Usín | Stunt Coordinator |
| Directing | Charlie Watson | First Assistant Director |
| Art | Nieves Monterde | Set Decoration |
| Directing | Maralyn Causley | Script Supervisor |
| Production | Lonnie Ramati | Co-Executive Producer |
| Visual Effects | Aleksander Aleksiev | Visual Effects Supervisor |
| Sound | Tapio Liukkonen | Foley Artist |
| Art | Kess Bonnet | Supervising Art Director |
| Art | Valentina Mladenova | Set Decoration |
| Production | Alberto Poveda Rey | Unit Production Manager |
| Directing | Paul Taylor | Second Assistant Director |
| Art | Emil Gigov | Art Direction |
| Visual Effects | Richard Van Den Bergh | Special Effects Supervisor |
| Visual Effects | Pau Costa | Special Effects Supervisor |
| Production | Vessela Bannzurkova | Unit Production Manager |
| Sound | Boris Tanchev | Boom Operator |
| Crew | Diyan Hristov | Stunt Coordinator |
| Lighting | Konstantin Vladimirov | Gaffer |
| Art | Dirk Buchmann | Property Master |
| Directing | Vern Nobles | Second Unit Director |
| Sound | Kris Casavant | Supervising Sound Editor |
| Camera | Rafael Rodriguez Lamas | Digital Imaging Technician |
| Lighting | Eduardo Camprubí | Electrician |
| Camera | Borislav Belberov | First Assistant Camera |
| Camera | Ivailo Tzvetkov | First Assistant "A" Camera |
| Camera | Don Cherel | Camera Operator |
| Camera | Des Whelan | Camera Operator |
| Camera | Ivan Vatsov | Camera Operator |
| Lighting | Sven Vohser | Electrician |
| Lighting | Héctor Gabriel García | Electrician |
| Camera | Dawid Pietkiewicz | Camera Operator |
| Lighting | Ognian Atanasov | Electrician |
| Camera | Ivo Velkov | Digital Imaging Technician |
| Camera | Lyubomir Somov | First Assistant "A" Camera |
| Camera | Dimitar Krustev | Drone Pilot |
| Camera | Ivana Vladić | First Assistant Camera |
| Production | Steven Paul | Producer |
| Camera | Simon Varsano | Still Photographer |
| Camera | Dave Isern | Steadicam Operator |
| Camera | Paula Nenova | First Assistant "B" Camera |
| Camera | Aleksandar Ribarski | Grip |
| Camera | Héctor Quintero Domínguez | Focus Puller |
| Camera | Ivelin Metodiev | First Assistant "C" Camera |
| Camera | Luis Cesar Izquierdo | Focus Puller |
| Costume & Make-Up | Daniela Avramova | Key Makeup Artist |
| Production | Eliseo Ruiz | Casting Associate |
| Camera | Desislav Dimitrov | Grip |
| Production | Natalie Ballesteros | Casting Associate |
| Production | Patricia Amor | Casting Associate |
| Costume & Make-Up | Paula Barroso | Costumer |
| Costume & Make-Up | Gara Hamad | Costumer |
| Costume & Make-Up | Katarina Pavlova | Costumer |
| Costume & Make-Up | Yurena Cazorla | Makeup Artist |
| Production | Mark Sussman | ADR Voice Casting |
| Production | Camilla-Valentine Isola | Casting |
| Costume & Make-Up | Fernando García Brea | Assistant Costume Designer |
| Costume & Make-Up | Eva Fervenza | Costume Supervisor |
| Costume & Make-Up | Stephen Prouty | Prosthetic Designer |
| Crew | Vern Nobles | Second Unit Cinematographer |
| Costume & Make-Up | Tiptalee Chanaputtakun | Hairstylist |
| Costume & Make-Up | Jasmina Vasileva | Costume Supervisor |
| Camera | Biser Rulev | Grip |
| Production | Hrista Ilieva | Extras Casting |
| Production | Cristina Santacreu | Extras Casting Assistant |
| Camera | Valentin Stanimirov | Grip |
| Costume & Make-Up | Fionagh Cush | Makeup Artist |
| Costume & Make-Up | Nuria Barrio | Set Costumer |
| Costume & Make-Up | Desislava Manasieva | Makeup Artist |
| Costume & Make-Up | Ralitsa Roth | Makeup Artist |
| Art | Tatiana Urquiza | Art Department Assistant |
| Visual Effects | Svetoslav Mitev | Visual Effects Coordinator |
| Lighting | Daniel Arenas Cortes | Lighting Artist |
| Visual Effects | Pedro Domingo Luque | Visual Effects Producer |
| Visual Effects | Magnus Olsson | 3D Artist |
| Crew | Diego Gortázar | CG Supervisor |
| Visual Effects | Alice Olson-Coons | Visual Effects Coordinator |
| Visual Effects | Anna Rovira Macià | Visual Effects Production Manager |
| Visual Effects | Alexander Kadim | Visual Effects Supervisor |
| Visual Effects | Andres Mas | Visual Effects Production Assistant |
| Art | Nieves Monterde | Set Designer |
| Visual Effects | A. Martín Puentes | Animation Supervisor |
| Visual Effects | Łukasz Kołtunowicz | Visual Effects Producer |
| Visual Effects | Helena Holmes | Special Effects Supervisor |
| Art | Orlando Harris | Graphic Designer |
| Art | Marimar Lara | Standby Painter |
| Art | Nikolai Nikolov | Set Designer |
| Visual Effects | Aleksey Hrzhehorzhevskyi | Visual Effects Coordinator |
| Art | Anna Hadzhieva | Set Decorating Coordinator |
| Visual Effects | Dragostin Valev | Compositing Supervisor |
| Art | Joseph Díaz | Concept Artist |
| Visual Effects | Danail Hadzhiyski | Visual Effects Producer |
| Visual Effects | Kristian Talajic | Visual Effects Supervisor |
| Art | Evgeni Yordanov | Construction Manager |
| Visual Effects | David Andreu | Animation |
| Visual Effects | Julia Manolova | Visual Effects Coordinator |
| Art | Pavlina Petrova | Concept Artist |
| Art | Krista Vacheva | Storyboard Artist |
| Editing | Ivan Todorov Ivanov | Assistant Editor |
| Art | Cristina Acuña | Standby Painter |
| Editing | Nedelko Tudzharov | First Assistant Editor |
| Editing | Bradley Greer | Digital Intermediate Colorist |
| Editing | Damian F. Gomez | First Assistant Editor |
| Art | Neil D'Monte | Storyboard Artist |
| Writing | Dan Gordon | Screenstory |
| Writing | Sylvester Stallone | Screenstory |
| Crew | Max Kraus | Stunts |
