Gefrustreerd door de koers die de Katholieke Kerk vaart, vraagt kardinaal Bergoglio (Jonathan Pryce) toestemming van paus Benedictus (Anthony Hopkins) om in 2012 met pensioen te gaan. In plaats van het ontslag te aanvaarden, roept de introverte paus Benedictus, geconfronteerd met laster en gebrek aan zelfvertrouwen, zijn meedogenloze criticaster en toekomstige opvolger van Rome op om een geheim te onthullen dat de fundamenten van de Katholieke Kerk op hun grondvesten doet schudden. Achter de Vaticaanse muren begint een tweestrijd tussen traditie en vooruitgang, schuld en vergeving. Onderwijl proberen deze twee zeer verschillende mannen hun eigen verleden het hoofd te bieden om op die manier een gemeenschappelijke basis te vinden en een toekomstperspectief te creëren voor de kerk en haar miljard volgers wereldwijd.
| Costume & Make-Up | Beatriz Di Benedetto | Costume Designer |
| Production | Javier Braier | Casting |
| Costume & Make-Up | Marese Langan | Makeup Designer |
| Art | Mark Tildesley | Production Design |
| Production | Mark Bauch | Executive Producer |
| Costume & Make-Up | Marese Langan | Hair Designer |
| Production | Gabriel Villegas | Casting |
| Production | Barbara Giordani | Casting |
| Production | Francesco Vedovati | Casting |
| Sound | Martin Cantwell | Sound Editor |
| Sound | Glen Gathard | Foley Mixer |
| Sound | Jemma Riley-Tolch | Foley Mixer |
| Sound | Mike Dowson | Sound Re-Recording Mixer |
| Costume & Make-Up | Jorge Palacios | Hairstylist |
| Costume & Make-Up | Stuart Richards | Special Effects Makeup Artist |
| Art | Matías Martínez | Art Direction |
| Sound | Phil Lee | Sound Effects Editor |
| Art | Natalia Mendiburu | Set Decoration |
| Production | Leticia Cristi | Producer |
| Sound | Lilly Blazewicz | Foley Editor |
| Sound | Jason Swanscott | Foley Artist |
| Sound | Adam Bourne | Foley Editor |
| Costume & Make-Up | Daniela Bayarres | Makeup Artist |
| Costume & Make-Up | Angela Garacija | Makeup Artist |
| Art | Alessio Panzironi | Set Decoration |
| Costume & Make-Up | Denise Stocker | Makeup Artist |
| Costume & Make-Up | Stefania Trippa | Makeup Artist |
| Production | Diego Robino | Executive Producer |
| Costume & Make-Up | Victoria Holt | Special Effects Makeup Artist |
| Sound | Peter Burgis | Foley Artist |
| Art | Rudy Campanella | Set Decoration |
| Art | German nagl | Set Decoration |
| Visual Effects | Karl Kuehn | Visual Effects Producer |
| Sound | Kath Pollard | Sound Re-Recording Mixer |
| Visual Effects | David Mir | Digital Compositor |
| Directing | Fernando Meirelles | Director |
| Costume & Make-Up | Luca Canfora | Costume Designer |
| Production | Dan Lin | Producer |
| Editing | Fernando Stutz | Editor |
| Camera | César Charlone | Director of Photography |
| Production | Tracey Seaward | Producer |
| Sound | Bryce Dessner | Original Music Composer |
| Production | Jonathan Eirich | Producer |
| Art | Saverio Sammali | Art Direction |
| Writing | Anthony McCarten | Screenplay |
| Art | Livia Del Priore | Set Decoration |
| Art | Véronique Melery | Set Decoration |
| Production | Nina Gold | Casting |
| Production | Vito Colazzo | Unit Production Manager |
