Gefrustreerd door de koers die de Katholieke Kerk vaart, vraagt kardinaal Bergoglio (Jonathan Pryce) toestemming van paus Benedictus (Anthony Hopkins) om in 2012 met pensioen te gaan. In plaats van het ontslag te aanvaarden, roept de introverte paus Benedictus, geconfronteerd met laster en gebrek aan zelfvertrouwen, zijn meedogenloze criticaster en toekomstige opvolger van Rome op om een geheim te onthullen dat de fundamenten van de Katholieke Kerk op hun grondvesten doet schudden. Achter de Vaticaanse muren begint een tweestrijd tussen traditie en vooruitgang, schuld en vergeving. Onderwijl proberen deze twee zeer verschillende mannen hun eigen verleden het hoofd te bieden om op die manier een gemeenschappelijke basis te vinden en een toekomstperspectief te creëren voor de kerk en haar miljard volgers wereldwijd.
| Production | Mark Bauch | Executive Producer |
| Art | Mark Tildesley | Production Design |
| Costume & Make-Up | Beatriz Di Benedetto | Costume Designer |
| Costume & Make-Up | Marese Langan | Makeup Designer |
| Costume & Make-Up | Marese Langan | Hair Designer |
| Production | Javier Braier | Casting |
| Production | Gabriel Villegas | Casting |
| Production | Barbara Giordani | Casting |
| Production | Francesco Vedovati | Casting |
| Production | Leticia Cristi | Producer |
| Production | Diego Robino | Executive Producer |
| Sound | Lilly Blazewicz | Foley Editor |
| Sound | Peter Burgis | Foley Artist |
| Sound | Martin Cantwell | Sound Editor |
| Sound | Mike Dowson | Sound Re-Recording Mixer |
| Sound | Glen Gathard | Foley Mixer |
| Sound | Phil Lee | Sound Effects Editor |
| Sound | Jemma Riley-Tolch | Foley Mixer |
| Sound | Jason Swanscott | Foley Artist |
| Sound | Adam Bourne | Foley Editor |
| Costume & Make-Up | Denise Stocker | Makeup Artist |
| Costume & Make-Up | Stefania Trippa | Makeup Artist |
| Costume & Make-Up | Daniela Bayarres | Makeup Artist |
| Costume & Make-Up | Stuart Richards | Special Effects Makeup Artist |
| Costume & Make-Up | Jorge Palacios | Hairstylist |
| Costume & Make-Up | Victoria Holt | Special Effects Makeup Artist |
| Costume & Make-Up | Angela Garacija | Makeup Artist |
| Art | Matías Martínez | Art Direction |
| Art | Rudy Campanella | Set Decoration |
| Art | Natalia Mendiburu | Set Decoration |
| Art | German nagl | Set Decoration |
| Art | Alessio Panzironi | Set Decoration |
| Visual Effects | Karl Kuehn | Visual Effects Producer |
| Sound | Kath Pollard | Sound Re-Recording Mixer |
| Visual Effects | David Mir | Digital Compositor |
| Directing | Fernando Meirelles | Director |
| Sound | Bryce Dessner | Original Music Composer |
| Production | Dan Lin | Producer |
| Production | Jonathan Eirich | Producer |
| Production | Tracey Seaward | Producer |
| Camera | César Charlone | Director of Photography |
| Editing | Fernando Stutz | Editor |
| Production | Mark Tildesley | Production Designer |
| Art | Saverio Sammali | Art Direction |
| Costume & Make-Up | Luca Canfora | Costume Designer |
| Art | Livia Del Priore | Set Decoration |
| Art | Véronique Melery | Set Decoration |
| Production | Nina Gold | Casting |
| Writing | Anthony McCarten | Screenplay |
