Gefrustreerd door de koers die de Katholieke Kerk vaart, vraagt kardinaal Bergoglio (Jonathan Pryce) toestemming van paus Benedictus (Anthony Hopkins) om in 2012 met pensioen te gaan. In plaats van het ontslag te aanvaarden, roept de introverte paus Benedictus, geconfronteerd met laster en gebrek aan zelfvertrouwen, zijn meedogenloze criticaster en toekomstige opvolger van Rome op om een geheim te onthullen dat de fundamenten van de Katholieke Kerk op hun grondvesten doet schudden. Achter de Vaticaanse muren begint een tweestrijd tussen traditie en vooruitgang, schuld en vergeving. Onderwijl proberen deze twee zeer verschillende mannen hun eigen verleden het hoofd te bieden om op die manier een gemeenschappelijke basis te vinden en een toekomstperspectief te creëren voor de kerk en haar miljard volgers wereldwijd.
| Production | Mark Bauch | Executive Producer |
| Production | Javier Braier | Casting |
| Production | Gabriel Villegas | Casting |
| Costume & Make-Up | Beatriz Di Benedetto | Costume Designer |
| Production | Francesco Vedovati | Casting |
| Costume & Make-Up | Marese Langan | Makeup Designer |
| Art | Mark Tildesley | Production Design |
| Production | Barbara Giordani | Casting |
| Costume & Make-Up | Marese Langan | Hair Designer |
| Sound | Lilly Blazewicz | Foley Editor |
| Sound | Jason Swanscott | Foley Artist |
| Art | Matías Martínez | Art Direction |
| Art | Alessio Panzironi | Set Decoration |
| Sound | Adam Bourne | Foley Editor |
| Costume & Make-Up | Stefania Trippa | Makeup Artist |
| Production | Diego Robino | Executive Producer |
| Costume & Make-Up | Angela Garacija | Makeup Artist |
| Costume & Make-Up | Denise Stocker | Makeup Artist |
| Costume & Make-Up | Jorge Palacios | Hairstylist |
| Costume & Make-Up | Victoria Holt | Special Effects Makeup Artist |
| Costume & Make-Up | Stuart Richards | Special Effects Makeup Artist |
| Sound | Phil Lee | Sound Effects Editor |
| Sound | Jemma Riley-Tolch | Foley Mixer |
| Sound | Peter Burgis | Foley Artist |
| Sound | Martin Cantwell | Sound Editor |
| Art | Natalia Mendiburu | Set Decoration |
| Art | German nagl | Set Decoration |
| Production | Leticia Cristi | Producer |
| Costume & Make-Up | Daniela Bayarres | Makeup Artist |
| Art | Rudy Campanella | Set Decoration |
| Sound | Mike Dowson | Sound Re-Recording Mixer |
| Sound | Glen Gathard | Foley Mixer |
| Visual Effects | Karl Kuehn | Visual Effects Producer |
| Sound | Kath Pollard | Sound Re-Recording Mixer |
| Visual Effects | David Mir | Digital Compositor |
| Directing | Fernando Meirelles | Director |
| Camera | César Charlone | Director of Photography |
| Production | Tracey Seaward | Producer |
| Art | Livia Del Priore | Set Decoration |
| Editing | Fernando Stutz | Editor |
| Costume & Make-Up | Luca Canfora | Costume Designer |
| Writing | Anthony McCarten | Screenplay |
| Sound | Bryce Dessner | Original Music Composer |
| Production | Dan Lin | Producer |
| Art | Saverio Sammali | Art Direction |
| Production | Mark Tildesley | Production Designer |
| Art | Véronique Melery | Set Decoration |
| Production | Nina Gold | Casting |
| Production | Jonathan Eirich | Producer |
