Een reeks moorden vindt plaats in de stad. Als de politie er niet in slaagt een oplossing te vinden, gaat een team van CBI-officieren onder leiding van CBI-officier Sethurama Iyer over tot het onderzoek om het mysterie op te lossen.
Ja! de film CBI 5: The Brain is nu beschikbaar om te kijken op Netflix in Nederland.
| Editing | Sreekar Prasad | Editor |
| Production | Babu Shahir | Executive Producer |
| Costume & Make-Up | Stephy Zaviour | Costume Designer |
| Crew | Aroma Mohan | Production Controller |
| Production | Saneesh Abraham | Co-Producer |
| Sound | Vicky Rk | Sound Designer |
| Costume & Make-Up | Pradeep Rangan | Makeup Designer |
| Camera | Saleesh Peringottukara | Still Photographer |
| Production | Manish Abraham | Co-Producer |
| Editing | Moksha Post | Digital Intermediate |
| Production | Anand Rajendran | Publicist |
| Sound | M. R. Rajakrishnan | Sound Mixer |
| Art | Cyril Kuruvilla | Production Design |
| Art | Sarathvinu | Title Designer |
| Editing | Shanmuga Pandian M | Colorist |
| Costume & Make-Up | S. George | Makeup Designer |
| Camera | Akhil George | Director of Photography |
| Sound | Jakes Bejoy | Original Music Composer |
| Production | Swargachitra Appachan | Producer |
| Sound | Aswaghosh Vidhya | Sound Recordist |
| Directing | K. Madhu | Director |
| Writing | S. N. Swamy | Writer |
