Terwijl Emily worstelt om zich thuis en op school aan te passen, ontdekt ze een kleine rode puppy die voorbestemd is om haar beste vriend te worden. Wanneer Clifford op magische wijze een enorme groeispurt doormaakt, een gigantische hond wordt en de aandacht trekt van een geneticabedrijf, moeten Emily en haar oom Casey de hebzuchtige krachten bevechten terwijl ze door New York City vluchten. Onderweg beïnvloedt Clifford de levens van iedereen om hem heen en leert Emily en haar oom de ware betekenis van acceptatie en onvoorwaardelijke liefde.
Nee, helaas is Clifford de grote rode hond nog niet beschikbaar op Netflix in Nederland.
| Production | Brian Bell | Executive Producer |
| Production | Amanda Mackey | Casting |
| Production | Bradley J. Fischer | Executive Producer |
| Visual Effects | Allen Battino | Character Designer |
| Camera | Peter Lyons Collister | Director of Photography |
| Production | Lisa Crnic | Executive Producer |
| Production | Deborah Forte | Executive Producer |
| Production | Brian Oliver | Executive Producer |
| Production | Jonathan Hook | Line Producer |
| Writing | Norman Bridwell | Characters |
| Costume & Make-Up | Milagros Medina-Cerdeira | Key Makeup Artist |
| Art | Naomi Shohan | Production Design |
| Production | Cathy Sandrich Gelfond | Casting |
| Production | Caitlin Friedman | Executive Producer |
| Sound | John Debney | Original Music Composer |
| Production | Stephen Vincent | Casting |
| Art | Christopher Minard | Art Direction |
| Production | Valerii An | Executive Producer |
| Editing | Sabrina Plisco | Editor |
| Production | Sig De Miguel | Casting |
| Costume & Make-Up | Susan Lyall | Costume Design |
| Costume & Make-Up | Barbara Lacy | Makeup Artist |
| Costume & Make-Up | Mindy Hall | Makeup Department Head |
| Costume & Make-Up | Donyale McRae | Makeup Artist |
| Costume & Make-Up | Jessica Toth | Makeup Artist |
| Costume & Make-Up | Cassandra Keating | Makeup Artist |
| Sound | Anna Behlmer | Sound Re-Recording Mixer |
| Art | Michelle Schluter-Ford | Set Decoration |
| Costume & Make-Up | Kristen Alimena | Makeup Artist |
| Costume & Make-Up | Etzel Ecleston | Makeup Artist |
| Sound | Joanna Fang | Foley Artist |
| Sound | Bennet Maples | ADR Recordist |
| Sound | Ryan Collison | Foley Mixer |
| Sound | Connor Nagy | Foley Mixer |
| Sound | Ken Strain | Boom Operator |
| Sound | Thomas Varga | Sound Mixer |
| Sound | Andrew DeCristofaro | Supervising Sound Editor |
| Sound | Judah Getz | ADR Mixer |
| Sound | Terry Porter | Sound Re-Recording Mixer |
| Sound | Ryan Collins | Sound Designer |
| Sound | Will Files | Sound Designer |
| Sound | Chris Navarro | ADR Mixer |
| Sound | Laura Heinzinger | Foley Editor |
| Sound | Leslie Bloome | Foley Artist |
| Costume & Make-Up | Laura Snider | Set Costumer |
| Visual Effects | Will Newis | Visual Effects Producer |
| Visual Effects | Irene Armit | Visual Effects Producer |
| Visual Effects | Blair Clark | Visual Effects Supervisor |
| Costume & Make-Up | Erica Suzanne Scott | Set Costumer |
| Art | Grant M Guilliams | Assistant Art Director |
| Costume & Make-Up | Shannon Gorman | Set Costumer |
| Art | Eric Fehlberg | Assistant Art Director |
| Visual Effects | Susan MacLeod | Visual Effects Producer |
| Costume & Make-Up | Tim McKelvey | Costume Supervisor |
| Costume & Make-Up | Esther J. Han | Set Costumer |
| Costume & Make-Up | Clifford Wray | Set Costumer |
| Art | Keith Stiegelbauer | Set Dresser |
| Art | Lisa Ramos | Set Dresser |
| Writing | Ellen Rapoport | Story |
| Writing | Blaise Hemingway | Screenplay |
| Writing | Justin Malen | Story |
| Visual Effects | Victor Rivas Alvarez | Digital Compositor |
| Lighting | Tarik Morgan | Electrician |
| Crew | Chris Cenatiempo | Stunts |
| Directing | Walt Becker | Director |
| Writing | David Ronn | Screenplay |
| Production | Jordan Kerner | Producer |
| Production | Deborah Forte | Producer |
| Writing | Jay Scherick | Screenplay |
| Camera | Joe Fugallo | Other |
