Terwijl Emily worstelt om zich thuis en op school aan te passen, ontdekt ze een kleine rode puppy die voorbestemd is om haar beste vriend te worden. Wanneer Clifford op magische wijze een enorme groeispurt doormaakt, een gigantische hond wordt en de aandacht trekt van een geneticabedrijf, moeten Emily en haar oom Casey de hebzuchtige krachten bevechten terwijl ze door New York City vluchten. Onderweg beïnvloedt Clifford de levens van iedereen om hem heen en leert Emily en haar oom de ware betekenis van acceptatie en onvoorwaardelijke liefde.
Nee, helaas is Clifford de grote rode hond nog niet beschikbaar op Netflix in Nederland.
| Production | Deborah Forte | Executive Producer |
| Production | Valerii An | Executive Producer |
| Production | Jonathan Hook | Line Producer |
| Production | Stephen Vincent | Casting |
| Visual Effects | Allen Battino | Character Designer |
| Production | Brian Oliver | Executive Producer |
| Writing | Norman Bridwell | Characters |
| Camera | Peter Lyons Collister | Director of Photography |
| Production | Brian Bell | Executive Producer |
| Sound | John Debney | Original Music Composer |
| Production | Amanda Mackey | Casting |
| Production | Caitlin Friedman | Executive Producer |
| Production | Sig De Miguel | Casting |
| Production | Bradley J. Fischer | Executive Producer |
| Editing | Sabrina Plisco | Editor |
| Production | Lisa Crnic | Executive Producer |
| Art | Naomi Shohan | Production Design |
| Production | Cathy Sandrich Gelfond | Casting |
| Costume & Make-Up | Cassandra Keating | Makeup Artist |
| Costume & Make-Up | Kristen Alimena | Makeup Artist |
| Sound | Anna Behlmer | Sound Re-Recording Mixer |
| Costume & Make-Up | Etzel Ecleston | Makeup Artist |
| Costume & Make-Up | Barbara Lacy | Makeup Artist |
| Costume & Make-Up | Donyale McRae | Makeup Artist |
| Costume & Make-Up | Jessica Toth | Makeup Artist |
| Costume & Make-Up | Susan Lyall | Costume Design |
| Art | Michelle Schluter-Ford | Set Decoration |
| Costume & Make-Up | Mindy Hall | Makeup Department Head |
| Costume & Make-Up | Milagros Medina-Cerdeira | Key Makeup Artist |
| Art | Christopher Minard | Art Direction |
| Sound | Judah Getz | ADR Mixer |
| Sound | Ryan Collins | Sound Designer |
| Sound | Joanna Fang | Foley Artist |
| Sound | Andrew DeCristofaro | Supervising Sound Editor |
| Sound | Ryan Collison | Foley Mixer |
| Sound | Connor Nagy | Foley Mixer |
| Sound | Leslie Bloome | Foley Artist |
| Sound | Bennet Maples | ADR Recordist |
| Sound | Laura Heinzinger | Foley Editor |
| Sound | Terry Porter | Sound Re-Recording Mixer |
| Sound | Ken Strain | Boom Operator |
| Sound | Thomas Varga | Sound Mixer |
| Sound | Will Files | Sound Designer |
| Sound | Chris Navarro | ADR Mixer |
| Costume & Make-Up | Shannon Gorman | Set Costumer |
| Costume & Make-Up | Esther J. Han | Set Costumer |
| Visual Effects | Blair Clark | Visual Effects Supervisor |
| Costume & Make-Up | Erica Suzanne Scott | Set Costumer |
| Art | Eric Fehlberg | Assistant Art Director |
| Art | Grant M Guilliams | Assistant Art Director |
| Visual Effects | Will Newis | Visual Effects Producer |
| Visual Effects | Irene Armit | Visual Effects Producer |
| Costume & Make-Up | Tim McKelvey | Costume Supervisor |
| Visual Effects | Susan MacLeod | Visual Effects Producer |
| Costume & Make-Up | Laura Snider | Set Costumer |
| Costume & Make-Up | Clifford Wray | Set Costumer |
| Art | Lisa Ramos | Set Dresser |
| Art | Keith Stiegelbauer | Set Dresser |
| Writing | Blaise Hemingway | Screenplay |
| Writing | Justin Malen | Story |
| Writing | Ellen Rapoport | Story |
| Visual Effects | Victor Rivas Alvarez | Digital Compositor |
| Lighting | Tarik Morgan | Electrician |
| Crew | Chris Cenatiempo | Stunts |
| Directing | Walt Becker | Director |
| Production | Jordan Kerner | Producer |
| Writing | David Ronn | Screenplay |
| Production | Deborah Forte | Producer |
| Writing | Jay Scherick | Screenplay |
