De film vertelt het verhaal van Blossom, Bubbles en Buttercup, drie jonge meiden die speciale krachten krijgen, superhelden worden en samenwerken om de slechtaardige gemuteerde aap Mojo te stoppen in zijn plan om de wereld te veroveren. Gebaseerd op de populaire gelijknamige televisie-serie.
Nee, helaas is The Powerpuff Girls Movie nog niet beschikbaar op Netflix in Nederland.
| Directing | Craig McCracken | Director |
| Directing | Dave Kupczyk | Layout |
| Editing | Rob Desales | Editor |
| Sound | James L. Venable | Original Music Composer |
| Production | Collette Sunderman | Casting |
| Production | Brian A. Miller | Executive Producer |
| Production | Nikki Vanzo | Executive In Charge Of Production |
| Production | Donna Castricone | Producer |
| Writing | Lauren Faust | Writer |
| Writing | Charlie Bean | Storyboard |
| Art | Mike Moon | Art Direction |
| Visual Effects | Genndy Tartakovsky | Animation Director |
| Production | Kathy Moore | Production Coordinator |
| Sound | Eric Freeman | Sound Editor |
| Writing | Amy Keating Rogers | Story |
| Writing | Craig McCracken | Writer |
| Writing | Don Shank | Story |
| Visual Effects | Shakeh Hagnazarian | Character Designer |
| Sound | Jim Hearn | Dialogue Editor |
| Writing | Paul Rudish | Writer |
| Production | Melissa Lugar | Production Manager |
| Art | Bruce Berkey | Background Designer |
| Production | Nancy Gorée | Production Coordinator |
| Sound | Joel Valentine | Sound Designer |
| Crew | Craig McCracken | Creator |
| Sound | Tom Syslo | Sound Editor |
| Writing | Don Shank | Writer |
| Writing | Lauren Faust | Storyboard |
| Writing | Don Shank | Storyboard |
| Production | Mark Norman | Co-Executive Producer |
| Writing | Paul Rudish | Story |
| Production | Mike Lazzo | Co-Executive Producer |
| Visual Effects | Chris Battle | Character Designer |
| Visual Effects | Andy Bialk | Character Designer |
| Visual Effects | Lauren Faust | Character Designer |
| Crew | Antonio Gonella | Technical Advisor |
| Writing | Charlie Bean | Story |
| Production | Jennifer Pelphrey | Supervising Producer |
| Art | Carey Yost | Storyboard Assistant |
| Visual Effects | Bob Logan | Character Designer |
| Visual Effects | Dexter Smith | Character Designer |
| Production | Linda Simensky | Co-Executive Producer |
| Writing | Craig McCracken | Story |
| Art | Paul Stec | Background Designer |
| Art | Keith Weesner | Background Designer |
| Writing | Paul Rudish | Storyboard |
| Sound | Roy Braverman | Sound Editor |
| Writing | Craig McCracken | Storyboard |
| Writing | Lauren Faust | Story |
| Art | Dexter Smith | Storyboard Assistant |
| Visual Effects | Carey Yost | Lead Character Designer |
| Visual Effects | Craig McCracken | Character Designer |
| Art | Frederick J. Gardner III | Background Designer |
| Production | Alicia Parkinson | Post Production Coordinator |
| Sound | Eric Freeman | Sound Re-Recording Mixer |
| Sound | Debra Mason | Foley Artist |
| Sound | Daisuke Sawa | Sound Editor |
| Sound | Jonathan McPherson | Foley Artist |
| Art | Justin K. Thompson | Background Designer |
| Art | Jim Worthy | Background Designer |
| Sound | Steve Worley | Foley Recordist |
| Editing | Ed Weyer | Color Timer |
| Editing | William DeBoer, Jr. | Negative Cutter |
| Sound | Joe Privitelli | Music Editor |
| Editing | Ron Sanders | Color Timer |
| Sound | Timothy J. Borquez | Sound Re-Recording Mixer |
| Production | Tammy List | Production Coordinator |
| Writing | Charlie Bean | Writer |
| Production | Craig McCracken | Executive Producer |
| Camera | Genndy Tartakovsky | Director of Photography |
