De centrale figuur in deze hallucinante film is Fred Madison, een saxofonist wiens huwelijk met Renee Madison bol staat van onuitgesproken spanningen. Die lopen nog hoger op wanneer ze anonieme videocassettes op hun stoep vinden, iets of iemand begluurt het huis en de bewoners.
Nee, helaas is Lost Highway nog niet beschikbaar op Netflix in Nederland.
| Directing | David Lynch | Director |
| Production | Deepak Nayar | Unit Production Manager |
| Production | Sabrina S. Sutherland | Production Supervisor |
| Directing | Cori Glazer | Script Supervisor |
| Art | Leslie Morales | Set Decoration |
| Costume & Make-Up | Debbie Zoller | Makeup Artist |
| Camera | Paul Hughen | Camera Operator |
| Camera | Suzanne Tenner | Still Photographer |
| Lighting | Michael LaViolette | Gaffer |
| Lighting | John Willis III | Best Boy Electric |
| Camera | Philip Sloan | Grip |
| Camera | Tim Collins | Grip |
| Camera | Todd Mitchell Griffith | Grip |
| Camera | Paul Wilkowsky | Grip |
| Camera | William Roy Eckert | Grip |
| Sound | Susumu Tokunow | Sound mixer |
| Sound | Kevin Kubota | Boom Operator |
| Production | Julie Duvic | Location Manager |
| Production | Karen R. Sachs | Production Manager |
| Production | Cynthia Wise | Production Accountant |
| Crew | Desmond Cannon | Post Production Supervisor |
| Sound | David Lynch | Sound Designer |
| Sound | Frank Gaeta | Supervising Sound Editor |
| Sound | John Ross | Sound Re-Recording Mixer |
| Sound | Frank Gaeta | Sound Re-Recording Mixer |
| Sound | Derek Marcil | Sound Re-Recording Mixer |
| Sound | David Lynch | Sound Re-Recording Mixer |
| Sound | Javier Bennassar | Sound Effects Editor |
| Sound | David Melhase | Sound Effects Editor |
| Sound | Benjamin L. Cook | Sound Effects Editor |
| Sound | Cormac Funge | Sound Effects Editor |
| Sound | Elmo Weber | Sound Effects Editor |
| Sound | Bill Brown | Sound Effects Editor |
| Sound | Dean Hovey | Sound Effects Editor |
| Sound | Frederick Howard | Sound Effects Editor |
| Sound | Marc Vanocur | Music Editor |
| Sound | Derek Marcil | ADR & Dubbing |
| Sound | Mary Erstad | Foley |
| Sound | Ossama Khuluki | Foley |
| Sound | Catherine Harper | Foley |
| Sound | Christopher Moriana | Foley |
| Sound | Ellen Heuer | Foley |
| Crew | Cassandra King | Post Production Assistant |
| Crew | David A. Poole | Special Effects |
| Crew | Michael Wilmot | Special Effects |
| Crew | Bart Barber | Special Effects |
| Art | Greg Polutonovich | Sculptor |
| Production | Ed Morris | Executive Consultant |
| Sound | Jiří Zobač | Sound Engineer |
| Production | Johanna Ray | Casting |
| Production | Elaine J. Huzzar | Casting |
| Editing | Mary Sweeney | Editor |
| Art | Patricia Norris | Production Design |
| Camera | Peter Deming | Director of Photography |
| Production | Tom Sternberg | Producer |
| Production | Mary Sweeney | Producer |
| Crew | Philip Bartko | Special Effects |
| Crew | Bruce Paul Barbour | Stunts |
| Production | Deepak Nayar | Producer |
| Writing | David Lynch | Writer |
| Writing | Barry Gifford | Writer |
| Crew | Chris Howell | Stunt Coordinator |
| Art | Eric DaRe | Property Buyer |
| Crew | Gene Hartline | Stunts |
| Crew | Joey Box | Stunts |
| Crew | Cole S. McKay | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Sound | David Grant | Dialogue Editor |
| Camera | Scott Andrew Ressler | First Assistant Camera |
| Sound | Angelo Badalamenti | Original Music Composer |
| Sound | Marilyn Graf | Foley Editor |
| Sound | David Mann | Foley Editor |
| Sound | Laura Laird | Foley Editor |
| Sound | Lucy Sustar | Foley Editor |
| Sound | Joshua E. Schneider | Foley Editor |
| Sound | Susan Shin | Dialogue Editor |
| Sound | Paul Longstaffe | Dialogue Editor |
| Sound | Louis Creveling | Dialogue Editor |
| Sound | Thomas Jones | Supervising Dialogue Editor |
| Art | Craig Sherman Hall | Property Master |
| Crew | Robert Jauregui | Stunts |
| Crew | Eliza Coleman | Stunts |
| Editing | Hilary Schroeder | Assistant Editor |
| Crew | Gilbert B. Combs | Stunts |
| Directing | Scott Cameron | First Assistant Director |
| Directing | Simone Farber | Second Assistant Director |
| Directing | Adam Rosen | Second Second Assistant Director |
| Costume & Make-Up | Patricia Miller | Hairstylist |
| Costume & Make-Up | Michael Burnett | Special Effects Makeup Artist |
| Costume & Make-Up | Hayley Cecile | Assistant Makeup Artist |
| Art | Russell J. Smith | Art Direction |
| Costume & Make-Up | Patricia Norris | Costume Design |
| Costume & Make-Up | Marisa Aboitiz | Set Costumer |
| Crew | Rick Seaman | Stunts |
| Costume & Make-Up | Marlene Lipman | Makeup Artist |
| Costume & Make-Up | Toni-Ann Walker | Hairstylist |
| Crew | Barry Adamson | Additional Music |
| Crew | David M. Barrett | Stunts |
| Crew | Terry Jackson | Stunts |
| Crew | Cole McLarty | Stunts |
| Crew | Jim Palmer | Stunts |
| Crew | Matt Sigloch | Stunts |
| Crew | Mike Watson | Stunts |
| Crew | Glen Yrigoyen | Stunts |
| Art | David Storm | Set Dresser |
| Art | Samuel J. Tell | Assistant Property Master |
| Costume & Make-Up | Maurizio Bizzarri | Costume Supervisor |
| Costume & Make-Up | Kathleen Norris | Assistant Hairstylist |
| Camera | Dan Kneece | Steadicam Operator |
| Camera | Stan McClain | Aerial Camera |
| Camera | Andrea Chesney | Second Assistant Camera |
| Editing | Brian Johnson | First Assistant Editor |
| Sound | Rammstein | Songs |
