Vietnam-veteraan John Rambo leeft al geruime tijd in een afgezonderde levensstijl in Bangkok. Op een dag wordt hij ingehuurd door een groep christelijke zendelingen om hen per boot te vervoeren naar Birma. Niet veel later wordt het dorp waar de zendelingen hun humanitaire missie uitvoeren aangevallen. Dit komt Rambo te weten als hij door diezelfde christelijke beweging wordt ingehuurd om een groep huurlingen te brengen naar het punt waar hij ze heeft achtergelaten in Birma. Samen met het team gaat hij op zoek naar de vermiste zendelingen.
| Production | Danny Dimbort | Executive Producer |
| Editing | Sean Albertson | Editor |
| Writing | Art Monterastelli | Screenplay |
| Writing | Sylvester Stallone | Screenplay |
| Production | John Thompson | Producer |
| Production | Avi Lerner | Producer |
| Production | Trevor Short | Executive Producer |
| Production | Kevin King Templeton | Producer |
| Directing | Sylvester Stallone | Director |
| Production | Boaz Davidson | Executive Producer |
| Writing | David Morrell | Original Story |
| Production | Sheila Jaffe | Casting |
| Costume & Make-Up | Scott H. Eddo | Makeup Department Head |
| Costume & Make-Up | Lizz Wolf | Costume Design |
| Production | Andreas Thiesmeyer | Executive Producer |
| Production | Kevin Bernhardt | Co-Producer |
| Art | Franco-Giacomo Carbone | Production Design |
| Production | Peter Block | Executive Producer |
| Production | Florian Lechner | Executive Producer |
| Production | Bob Weinstein | Executive Producer |
| Art | Suchartanun 'Kai' Kuladee | Art Direction |
| Production | Harvey Weinstein | Executive Producer |
| Production | Joachim Sturmes | Co-Producer |
| Production | Matthew O'Toole | Line Producer |
| Production | Josef Lautenschlager | Co-Producer |
| Production | Randall Emmett | Executive Producer |
| Production | George Furla | Executive Producer |
| Production | Christopher Petzel | Associate Producer |
| Production | Jon Feltheimer | Executive Producer |
| Production | Russell D. Markowitz | Line Producer |
| Sound | Brian Tyler | Original Music Composer |
| Camera | Glen MacPherson | Director of Photography |
| Crew | Stanimir Stamatov | Stunt Double |
| Crew | Heidi Moneymaker | Stunt Double |
| Crew | Chad Stahelski | Stunt Coordinator |
| Camera | Anusorn Poonsup | Grip |
| Camera | Karen Ballard | Still Photographer |
| Crew | Daren Bailey | Marine Coordinator |
| Art | Audrey A. Johnson | Assistant Property Master |
| Costume & Make-Up | Pipat Sripradoo | On Set Dresser |
| Camera | Kenny Groom | Assistant Camera |
| Production | Tanawat Punya | Extras Casting |
| Crew | Wanchai 'Jockey' Jaipongsai | Transportation Captain |
| Art | Somm Suthinee Chantakarn | Art Department Coordinator |
| Camera | Vern Nobles | Additional Photography |
| Lighting | Michael Galbraith | Gaffer |
| Costume & Make-Up | Preeyanan Suwannathada | Wardrobe Assistant |
| Directing | Navarutt Roongaroon | Script Supervisor |
| Art | Brandi Hugo | Art Department Coordinator |
| Art | Christine Reins | Assistant Art Director |
| Lighting | Tom Starnes | Rigging Gaffer |
| Costume & Make-Up | Nicole Venables | Key Hair Stylist |
| Production | Susan Paley Abramson | Casting Associate |
| Camera | Rittikorn Manonom | Camera Operator |
| Costume & Make-Up | Sean Gundlach | Costume Supervisor |
| Camera | Daniel Page McDonough | Camera Operator |
| Costume & Make-Up | Sayun Santon | Hairstylist |
| Costume & Make-Up | Maneerath Vijob | Key Hair Stylist |
| Crew | Jeanmarie Murphy-Burke | Unit Publicist |
| Camera | Gilles Corbeil | Steadicam Operator |
| Costume & Make-Up | Watana Garum | Makeup Artist |
| Costume & Make-Up | John Schoonraad | Prosthetics |
| Art | Kent H. Johnson | Property Master |
| Costume & Make-Up | Makoree Waekaji | Assistant Makeup Artist |
| Art | Witoon Suanyai | Set Decoration |
| Camera | Richard Osborn Jr. | First Assistant Camera |
| Crew | Jimi Johnson | Video Assist Operator |
| Camera | Michael E. Matteson | Key Grip |
| Crew | Pawin Chantanimi | Marine Coordinator |
| Camera | Boonleang Thaisaman | Grip |
| Costume & Make-Up | Christy Wyatt | Assistant Hairstylist |
| Costume & Make-Up | Piyathida Phorung | Assistant Hairstylist |
| Directing | Rebecca Poulos | Script Supervisor |
| Costume & Make-Up | Mark Brooks | On Set Dresser |
| Lighting | Pat Liampetchakul | Rigging Grip |
| Costume & Make-Up | Ngamta Somboon | Makeup Artist |
| Production | Matt Rubenstein | Casting Assistant |
| Costume & Make-Up | Jaclyn Tamizato | Assistant Costume Designer |
| Sound | Gary Krause | Music Editor |
| Camera | Ron Veto | Steadicam Operator |
| Costume & Make-Up | Vasit Suchitta | Prosthetics |
| Lighting | Chesda 'Pop' Smithsuth | Gaffer |
| Crew | Harry Lu | Armorer |
| Crew | Chidchanok Plodripu | Transportation Coordinator |
| Sound | Robert Elhai | Orchestrator |
| Sound | Selena Arizanovic | Music Coordinator |
| Sound | Joe Lisanti | Music Editor |
| Sound | Jeff Toyne | Orchestrator |
| Sound | Michelle Pazer | ADR Editor |
| Sound | Derek Vanderhorst | Sound Effects Editor |
| Sound | Scott Sanders | Supervising Sound Editor |
| Editing | Harry Muller | Color Timer |
| Sound | Pat Cassin | Boom Operator |
| Sound | Kyle Billingsley | Foley Mixer |
| Sound | Gabriel J. Serrano | Sound Recordist |
| Editing | Allan Levine | Digital Intermediate Producer |
| Sound | James Bailey | Foley Artist |
| Sound | Donald Flick | Sound Editor |
| Editing | Paul Bronkar | Digital Intermediate Colorist |
| Sound | Nick Neutra | Foley Supervisor |
| Sound | Greg Chapman | Sound Mixer |
| Editing | Scott K. Wallace | Additional Editor |
| Sound | Scott Sanders | Sound Designer |
| Editing | Nona Khodai | Assistant Editor |
| Sound | Rickley W. Dumm | Sound Effects Editor |
| Visual Effects | Yakim Petrov | Animation |
| Sound | Marshall Garlington | Sound Re-Recording Mixer |
| Sound | Barney Cabral | Supervising Sound Editor |
| Editing | Jon Pehlke | Digital Intermediate Editor |
| Visual Effects | Boyan Stoyanov | Animation |
| Sound | Chris David | Sound Re-Recording Mixer |
| Editing | David Graubard | Digital Intermediate |
| Sound | Leslie Shatz | Sound Re-Recording Mixer |
| Sound | Richard Dwan Jr. | Supervising Dialogue Editor |
| Sound | Perry Robertson | Supervising Sound Editor |
| Sound | Kevin Zimmerman | First Assistant Sound Editor |
| Sound | Eric Thompson | ADR Mixer |
| Editing | Evan Schiff | Assistant Editor |
| Editing | Chris Ward | Digital Intermediate Producer |
| Editing | Craig W. Smith | First Assistant Editor |
| Sound | Annop Jaikaew | Boom Operator |
| Editing | David Walters | Digital Intermediate |
| Visual Effects | Ivaylo Andonov | Digital Compositor |
| Visual Effects | Ivelina Dobreva | Digital Compositor |
| Visual Effects | Milan Stoyanov | Digital Compositor |
| Visual Effects | Maria Popova | Digital Compositor |
| Visual Effects | Konstantin Dimitrov | Digital Compositor |
| Visual Effects | Desislava Valcheva | Digital Compositor |
| Crew | Simeon Asenov | Visual Effects Art Director |
| Crew | Desislava Lazarova | Visual Effects Editor |
| Visual Effects | Albena Ivanova | Digital Compositor |
| Visual Effects | Diana Moneva | Digital Compositor |
| Crew | Paul Stemmer | Visual Effects Editor |
| Visual Effects | Wes C. Caefer | Visual Effects Supervisor |
| Visual Effects | Kiril Gizdov | Digital Compositor |
| Visual Effects | Julia Petrova | Digital Compositor |
| Crew | Jordan Markov | Visual Effects Editor |
| Visual Effects | Dimitrina Torneva | Digital Compositor |
| Visual Effects | Milena Peneva | Visual Effects Coordinator |
| Visual Effects | Rosen Ivanov | Digital Compositor |
| Visual Effects | Denitsa Dimitrova | Digital Compositor |
| Visual Effects | Momchil Kirov | Digital Compositor |
| Visual Effects | Anton Donchev | Digital Compositor |
| Visual Effects | Momchil Koev | Visual Effects Compositor |
| Visual Effects | Scott Coulter | Visual Effects Producer |
| Visual Effects | Velichko Ivanov | Visual Effects Supervisor |
| Visual Effects | Plamen Statev | Visual Effects Coordinator |
| Visual Effects | Nikolay Gachev | Visual Effects Supervisor |
| Crew | Gerald McCrory | Pyrotechnician |
| Visual Effects | Stanislav Dragiev | Visual Effects Supervisor |
| Visual Effects | Veselina Georgieva | Visual Effects Supervisor |
| Visual Effects | Danny S. Kim | Visual Effects Supervisor |
| Visual Effects | Svilen Aynadzhiev | Digital Compositor |
| Visual Effects | Elin Davidov | Matte Painter |
| Crew | Migs Rustia | Visual Effects Editor |
| Visual Effects | Peter Tomov | Visual Effects Supervisor |
| Art | Lyubomir Grigorov | Concept Artist |
| Visual Effects | Nikolay Mihailov | Digital Compositor |
| Visual Effects | Nick Peshunoff | Visual Effects Coordinator |
| Visual Effects | Petko Zhivkov | Digital Compositor |
| Visual Effects | John K. Stirber | Special Effects Supervisor |
| Crew | Tristan Schoonraad | Pyrotechnician |
| Visual Effects | Alexander Gunn | Special Effects Supervisor |
| Crew | Rangsun Rangsimaporn | Special Effects Coordinator |
| Costume & Make-Up | John Schoonraad | Prosthetic Supervisor |
| Crew | Sawang Yodnen | Pyrotechnician |
| Production | Phasiri Panya | Casting |
