Vietnam-veteraan John Rambo leeft al geruime tijd in een afgezonderde levensstijl in Bangkok. Op een dag wordt hij ingehuurd door een groep christelijke zendelingen om hen per boot te vervoeren naar Birma. Niet veel later wordt het dorp waar de zendelingen hun humanitaire missie uitvoeren aangevallen. Dit komt Rambo te weten als hij door diezelfde christelijke beweging wordt ingehuurd om een groep huurlingen te brengen naar het punt waar hij ze heeft achtergelaten in Birma. Samen met het team gaat hij op zoek naar de vermiste zendelingen.
| Directing | Sylvester Stallone | Director |
| Writing | Art Monterastelli | Screenplay |
| Writing | Sylvester Stallone | Screenplay |
| Production | Avi Lerner | Producer |
| Production | John Thompson | Producer |
| Production | Danny Dimbort | Executive Producer |
| Production | Boaz Davidson | Executive Producer |
| Production | Trevor Short | Executive Producer |
| Editing | Sean Albertson | Editor |
| Writing | David Morrell | Original Story |
| Production | Kevin King Templeton | Producer |
| Production | Sheila Jaffe | Casting |
| Costume & Make-Up | Lizz Wolf | Costume Design |
| Costume & Make-Up | Scott H. Eddo | Makeup Department Head |
| Sound | Brian Tyler | Original Music Composer |
| Production | Kevin Bernhardt | Co-Producer |
| Production | Peter Block | Executive Producer |
| Production | Randall Emmett | Executive Producer |
| Production | Jon Feltheimer | Executive Producer |
| Production | George Furla | Executive Producer |
| Production | Josef Lautenschlager | Co-Producer |
| Production | Florian Lechner | Executive Producer |
| Production | Russell D. Markowitz | Line Producer |
| Production | Matthew O'Toole | Line Producer |
| Production | Christopher Petzel | Associate Producer |
| Production | Joachim Sturmes | Co-Producer |
| Production | Andreas Thiesmeyer | Executive Producer |
| Production | Bob Weinstein | Executive Producer |
| Production | Harvey Weinstein | Executive Producer |
| Camera | Glen MacPherson | Director of Photography |
| Art | Franco-Giacomo Carbone | Production Design |
| Art | Suchartanun 'Kai' Kuladee | Art Direction |
| Crew | Stanimir Stamatov | Stunt Double |
| Crew | Heidi Moneymaker | Stunt Double |
| Crew | Chad Stahelski | Stunt Coordinator |
| Art | Witoon Suanyai | Set Decoration |
| Art | Brandi Hugo | Art Department Coordinator |
| Art | Somm Suthinee Chantakarn | Art Department Coordinator |
| Art | Christine Reins | Assistant Art Director |
| Art | Audrey A. Johnson | Assistant Property Master |
| Costume & Make-Up | Pipat Sripradoo | On Set Dresser |
| Costume & Make-Up | Mark Brooks | On Set Dresser |
| Art | Kent H. Johnson | Property Master |
| Camera | Kenny Groom | Assistant Camera |
| Camera | Daniel Page McDonough | Camera Operator |
| Camera | Rittikorn Manonom | Camera Operator |
| Camera | Vern Nobles | Additional Photography |
| Camera | Richard Osborn Jr. | First Assistant Camera |
| Lighting | Michael Galbraith | Gaffer |
| Lighting | Chesda 'Pop' Smithsuth | Gaffer |
| Camera | Anusorn Poonsup | Grip |
| Camera | Boonleang Thaisaman | Grip |
| Camera | Michael E. Matteson | Key Grip |
| Lighting | Tom Starnes | Rigging Gaffer |
| Lighting | Pat Liampetchakul | Rigging Grip |
| Camera | Gilles Corbeil | Steadicam Operator |
| Camera | Ron Veto | Steadicam Operator |
| Camera | Karen Ballard | Still Photographer |
| Crew | Jimi Johnson | Video Assist Operator |
| Costume & Make-Up | Christy Wyatt | Assistant Hairstylist |
| Costume & Make-Up | Piyathida Phorung | Assistant Hairstylist |
| Costume & Make-Up | Makoree Waekaji | Assistant Makeup Artist |
| Costume & Make-Up | Sayun Santon | Hairstylist |
| Costume & Make-Up | Nicole Venables | Key Hair Stylist |
| Costume & Make-Up | Maneerath Vijob | Key Hair Stylist |
| Costume & Make-Up | Ngamta Somboon | Makeup Artist |
| Costume & Make-Up | Watana Garum | Makeup Artist |
| Costume & Make-Up | John Schoonraad | Prosthetics |
| Costume & Make-Up | Vasit Suchitta | Prosthetics |
| Production | Matt Rubenstein | Casting Assistant |
| Production | Susan Paley Abramson | Casting Associate |
| Production | Tanawat Punya | Extras Casting |
| Costume & Make-Up | Jaclyn Tamizato | Assistant Costume Designer |
| Costume & Make-Up | Sean Gundlach | Costume Supervisor |
| Costume & Make-Up | Preeyanan Suwannathada | Wardrobe Assistant |
| Crew | Harry Lu | Armorer |
| Crew | Pawin Chantanimi | Marine Coordinator |
| Crew | Daren Bailey | Marine Coordinator |
| Directing | Rebecca Poulos | Script Supervisor |
| Directing | Navarutt Roongaroon | Script Supervisor |
| Crew | Jeanmarie Murphy-Burke | Unit Publicist |
| Crew | Chidchanok Plodripu | Transportation Coordinator |
| Crew | Wanchai 'Jockey' Jaipongsai | Transportation Captain |
| Sound | Selena Arizanovic | Music Coordinator |
| Sound | Joe Lisanti | Music Editor |
| Sound | Gary Krause | Music Editor |
| Sound | Robert Elhai | Orchestrator |
| Sound | Jeff Toyne | Orchestrator |
| Sound | Michelle Pazer | ADR Editor |
| Sound | Eric Thompson | ADR Mixer |
| Sound | Pat Cassin | Boom Operator |
| Sound | Annop Jaikaew | Boom Operator |
| Sound | Kevin Zimmerman | First Assistant Sound Editor |
| Sound | James Bailey | Foley Artist |
| Sound | Kyle Billingsley | Foley Mixer |
| Sound | Nick Neutra | Foley Supervisor |
| Sound | Scott Sanders | Sound Designer |
| Sound | Donald Flick | Sound Editor |
| Sound | Rickley W. Dumm | Sound Effects Editor |
| Sound | Derek Vanderhorst | Sound Effects Editor |
| Sound | Greg Chapman | Sound Mixer |
| Sound | Gabriel J. Serrano | Sound Recordist |
| Sound | Chris David | Sound Re-Recording Mixer |
| Sound | Marshall Garlington | Sound Re-Recording Mixer |
| Sound | Leslie Shatz | Sound Re-Recording Mixer |
| Sound | Richard Dwan Jr. | Supervising Dialogue Editor |
| Sound | Scott Sanders | Supervising Sound Editor |
| Sound | Barney Cabral | Supervising Sound Editor |
| Sound | Perry Robertson | Supervising Sound Editor |
| Editing | Scott K. Wallace | Additional Editor |
| Editing | Nona Khodai | Assistant Editor |
| Editing | Evan Schiff | Assistant Editor |
| Editing | Harry Muller | Color Timer |
| Editing | Paul Bronkar | Digital Intermediate Colorist |
| Editing | Jon Pehlke | Digital Intermediate Editor |
| Editing | Allan Levine | Digital Intermediate Producer |
| Editing | Chris Ward | Digital Intermediate Producer |
| Editing | David Graubard | Digital Intermediate |
| Editing | David Walters | Digital Intermediate |
| Editing | Craig W. Smith | First Assistant Editor |
| Visual Effects | Yakim Petrov | Animation |
| Visual Effects | Boyan Stoyanov | Animation |
| Art | Lyubomir Grigorov | Concept Artist |
| Visual Effects | Ivaylo Andonov | Digital Compositor |
| Visual Effects | Svilen Aynadzhiev | Digital Compositor |
| Visual Effects | Konstantin Dimitrov | Digital Compositor |
| Visual Effects | Denitsa Dimitrova | Digital Compositor |
| Visual Effects | Ivelina Dobreva | Digital Compositor |
| Visual Effects | Anton Donchev | Digital Compositor |
| Visual Effects | Kiril Gizdov | Digital Compositor |
| Visual Effects | Rosen Ivanov | Digital Compositor |
| Visual Effects | Albena Ivanova | Digital Compositor |
| Visual Effects | Momchil Kirov | Digital Compositor |
| Visual Effects | Nikolay Mihailov | Digital Compositor |
| Visual Effects | Diana Moneva | Digital Compositor |
| Visual Effects | Julia Petrova | Digital Compositor |
| Visual Effects | Milan Stoyanov | Digital Compositor |
| Visual Effects | Dimitrina Torneva | Digital Compositor |
| Visual Effects | Desislava Valcheva | Digital Compositor |
| Visual Effects | Petko Zhivkov | Digital Compositor |
| Visual Effects | Maria Popova | Digital Compositor |
| Visual Effects | Elin Davidov | Matte Painter |
| Crew | Simeon Asenov | Visual Effects Art Director |
| Visual Effects | Momchil Koev | Visual Effects Compositor |
| Visual Effects | Milena Peneva | Visual Effects Coordinator |
| Visual Effects | Nick Peshunoff | Visual Effects Coordinator |
| Visual Effects | Plamen Statev | Visual Effects Coordinator |
| Crew | Desislava Lazarova | Visual Effects Editor |
| Crew | Jordan Markov | Visual Effects Editor |
| Crew | Migs Rustia | Visual Effects Editor |
| Crew | Paul Stemmer | Visual Effects Editor |
| Visual Effects | Scott Coulter | Visual Effects Producer |
| Visual Effects | Wes C. Caefer | Visual Effects Supervisor |
| Visual Effects | Stanislav Dragiev | Visual Effects Supervisor |
| Visual Effects | Nikolay Gachev | Visual Effects Supervisor |
| Visual Effects | Veselina Georgieva | Visual Effects Supervisor |
| Visual Effects | Velichko Ivanov | Visual Effects Supervisor |
| Visual Effects | Danny S. Kim | Visual Effects Supervisor |
| Visual Effects | Peter Tomov | Visual Effects Supervisor |
| Costume & Make-Up | John Schoonraad | Prosthetic Supervisor |
| Crew | Gerald McCrory | Pyrotechnician |
| Crew | Tristan Schoonraad | Pyrotechnician |
| Crew | Sawang Yodnen | Pyrotechnician |
| Crew | Rangsun Rangsimaporn | Special Effects Coordinator |
| Visual Effects | Alexander Gunn | Special Effects Supervisor |
| Visual Effects | John K. Stirber | Special Effects Supervisor |
| Production | Phasiri Panya | Casting |
