Diverse stelletjes worstelen met hun problemen en hun verhalen raken in elkaar verstrengeld. Antonio, een voormalige Napolitaanse apotheker en nu lid van het Europees Parlement, begint een relatie met Olga, die hij ontmoette in een hotel in München. Max, een verstrooide Romeinse architect, ligt in scheiding. Dan wordt hij verliefd op Sandra, niet wetende dat dit de advocaat is van zijn vrouw. Marco, net getrouwd met Floriana, komt na jaren Consuelo, een oude liefde, weer tegen en doet alsof hij niet getrouwd is. Fabio is suïcidaal nadat zijn vriendin het uitmaakte door middel van een sms. Bij de praktijk van zijn psychiater ontmoet hij Valentina.
Nee, helaas is Ex - Amici come prima! nog niet beschikbaar op Netflix in Nederland.
| Directing | Carlo Vanzina | Director |
| Sound | Giuliano Taviani | Original Music Composer |
| Sound | Carmelo Travia | Original Music Composer |
| Production | Alessandro Pantano | Production Secretary |
| Production | Federico Santangelo | Location Manager |
| Costume & Make-Up | Biasi Pierangela | Makeup Artist |
| Camera | Gianpaolo Majorana | Key Grip |
| Editing | Marina Verri | Assistant Editor |
| Writing | Enrico Vanzina | Story |
| Sound | Marco Grillo | Sound |
| Directing | Paola Mengoni | Script Supervisor |
| Editing | Shara Spinella | Assistant Editor |
| Art | Daniela Zorzetto | Set Decoration |
| Art | Anca Rafan | Assistant Production Design |
| Production | Giulio Steve | Delegated Producer |
| Production | Clara Mancini | Administration |
| Production | Rita Tamantini | Unit Manager |
| Production | Maria Raffaella Faggiano | Location Manager |
| Camera | Daniela Chioffi | Second Assistant Camera |
| Production | Federica Lucisano | Producer |
| Costume & Make-Up | Gino Tamagnini | Makeup Department Head |
| Editing | Raimondo Crociani | Editor |
| Directing | Giorgio Melidoni | First Assistant Director |
| Production | Aldo Piccapane | Production Secretary |
| Sound | Alessandro Giacco | Foley Artist |
| Art | Tonino Zera | Production Design |
| Production | Barbara Giordani | Casting |
| Visual Effects | Paola Trisoglio | Visual Effects Producer |
| Writing | Carlo Vanzina | Screenplay |
| Costume & Make-Up | Nicoletta Ercole | Costume Design |
| Camera | Duccio Maccari | First Assistant Camera |
| Camera | Maria Marin | Still Photographer |
| Sound | Andrea Lancia | Sound Mixer |
| Visual Effects | Stefano Marinoni | VFX Supervisor |
| Production | Simona Vescovi | Line Producer |
| Directing | Matteo Vicario | Second Assistant Director |
| Costume & Make-Up | Adel Saada | Hair Department Head |
| Production | Fulvio Lucisano | Producer |
| Sound | Claudio Paolucci | Boom Operator |
| Sound | Dave Tinsley | Sound Editor |
| Writing | Enrico Vanzina | Screenplay |
| Production | Salvatore Morello | Executive Producer |
| Camera | Sascia Ippoliti | Steadicam Operator |
| Art | Gaia Zambelli | Assistant Production Design |
| Writing | Carlo Vanzina | Story |
| Production | Edoardo Moracci | Unit Manager |
| Production | Andrea Zampetti | Production Accountant |
| Crew | Federico Cioccolanti | Post Production Supervisor |
| Camera | Roberto Luzzi | Camera Operator |
| Camera | Giacomo Zampieri | Second Assistant Camera |
| Camera | Carlo Tafani | Director of Photography |
| Production | Sabrina Serangeli | Production Coordinator |
| Lighting | Massimo Cecchini | Gaffer |
| Costume & Make-Up | Giammarco Gaeta | Hairstylist |
| Sound | Thomas Giorgi | Sound Effects Editor |