Armando Alvarez (Will Ferrell) heeft zijn hele leven op de Mexicaanse ranch van zijn vader gewerkt. Wanneer de ranch in financiële problemen komt verschijnt Armando's jongere broer Raul (Diego Luna) met zijn nieuwe verloofde Sonia (Genesis Rodriguez). Het lijkt er op dat Rauls succes als internationale zakenman de redding voor de ranch kan betekenen als hij belooft alle schulden op zich te nemen. Maar wanneer Armando voor Sonia valt en Rauls zakelijk activiteiten niet geheel legaal blijken te zijn breekt de hel los, en komen ze in oorlog met de meest gevreesde drugsbaron van Mexico, de machtige Onza (Gael Garcia Bernal).
Nee, helaas is Casa de Mi Padre nog niet beschikbaar op Netflix in Nederland.
| Art | Kevin Kavanaugh | Production Design |
| Art | Meg Everist | Set Decoration |
| Sound | John Nau | Original Music Composer |
| Production | Allison Jones | Casting |
| Costume & Make-Up | Trayce Gigi Field | Costume Design |
| Sound | Andrew Feltenstein | Original Music Composer |
| Directing | Matt Piedmont | Director |
| Editing | David Trachtenberg | Editor |
| Art | Naaman Marshall | Art Direction |
| Production | Brittany Petros | Location Manager |
| Crew | Melissa R. Stubbs | Stunt Double |
| Crew | Mark De Alessandro | Stunts |
| Production | Kevin J. Messick | Executive Producer |
| Production | Billy Rovzar | Executive Producer |
| Production | Rudy Scalese | Co-Producer |
| Sound | Derek Somaru | Music Editor |
| Crew | Ricky Damazio | Transportation Coordinator |
| Crew | Ben Barsky | Transportation Captain |
| Production | Bernadette Gonzales | Production Office Coordinator |
| Production | Darlene Caamano Loquet | Producer |
| Production | Adam McKay | Producer |
| Production | Damien Lubiak | Production Supervisor |
| Crew | Todd Bryant | Stunt Coordinator |
| Writing | Harper Steele | Writer |
| Camera | Ramsey Nickell | Director of Photography |
| Crew | Michael Tinger | Post Production Supervisor |
| Production | D. Scott Lumpkin | Unit Production Manager |
| Production | Emilio Diez Barroso | Producer |
| Production | Harper Steele | Producer |
| Production | D. Scott Lumpkin | Executive Producer |
| Camera | John Estes | Still Photographer |
| Art | Jennifer Durban | Set Decoration Buyer |
| Production | Jessica Elbaum | Executive Producer |
| Production | Will Ferrell | Producer |
| Directing | Eric Fox Hays | First Assistant Director |
| Production | Fernando Rovzar | Executive Producer |
| Directing | Hope Garrison | Second Assistant Director |
| Camera | Stephan Collins | Camera Operator |
| Sound | Michael B. Koff | Sound Mixer |
| Production | Alex García | Executive Producer |
| Art | Benjamin Nowicki | Art Department Coordinator |
| Production | Maggie Means | Production Accountant |
| Directing | Liliana M. Molina | Script Supervisor |
| Production | Kei Rowan-Young | Location Manager |
| Crew | Lance Jay Velazco | Video Assist Operator |
| Costume & Make-Up | Nicole Artmont | Key Makeup Artist |
| Costume & Make-Up | Steve Artmont | Makeup Department Head |
| Costume & Make-Up | Stephanie Colin | Costume Supervisor |
| Sound | Michael J. Anastasi | Sound Designer |
| Costume & Make-Up | Bridget Cook | Hair Department Head |
| Sound | Nash Cubero Jr. | Foley Editor |
| Costume & Make-Up | Darrell Redleaf-Fielder | Key Hair Stylist |
| Sound | Richard Kitting | Sound Re-Recording Mixer |
| Sound | Michael J. Anastasi | Supervising Sound Editor |
| Sound | Jonathan Wales | Sound Re-Recording Mixer |
| Sound | James Heraz | Assistant Sound Editor |
| Sound | Andres Velasquez | Sound Effects Editor |
| Sound | Steven Iba | ADR Mixer |
| Sound | Daniel Norwick | Assistant Sound Editor |
| Sound | Angela Hemingway | Dialogue Editor |
| Sound | Jason Gaya | ADR Mixer |
| Sound | Joshua Adeniji | Sound Effects Editor |
| Sound | Angela Hemingway | ADR Editor |
| Sound | Chris Terhune | Assistant Sound Editor |
| Sound | Darren Lodwick | Assistant Sound Editor |
