Roberta, de jonge gefrustreerde echtgenote van een verkoper van badkuipen, is helemaal gefascineerd door een oproepje in de krant. 'Wanhopig gezocht: Susan' luidt de tekst, en de afzender is een zekere Jim die een afspraak wil maken in het New Yorkse Battery Park. Roberta besluit naar de afgesproken plek te gaan en daar wordt ze prompt met Susan verwisseld. Zo ontmoet ze Dez, de vriend van Jim, die zeer van haar gecharmeerd is. Maar hij is niet de enige die achter haar aanzit. Er is namelijk ook nog een moordenaar die jacht maakt op een paar oorringen die in het bezit zijn van Susan...
Nee, helaas is Desperately Seeking Susan nog niet beschikbaar op Netflix in Nederland.
| Directing | Susan Seidelman | Director |
| Writing | Leora Barish | Writer |
| Camera | Debbie Sarjeant | Second Assistant Camera |
| Art | Glenn Lloyd | Art Department Coordinator |
| Costume & Make-Up | Melissa Stanton | Wardrobe Supervisor |
| Sound | Linda Murphy | Boom Operator |
| Production | Shelley Houis | Production Office Coordinator |
| Art | Speed Hopkins | Art Direction |
| Art | Leslie Bloom | Property Master |
| Sound | Mark Rathaus | Sound Editor |
| Lighting | Ray Quinlan | Gaffer |
| Sound | Peter Odabashian | Sound Editor |
| Directing | Joel Tuber | First Assistant Director |
| Production | Todd M. Thaler | Additional Casting |
| Camera | Tom Prate | Key Grip |
| Directing | David Dreyfuss | Second Assistant Director |
| Costume & Make-Up | William A. Campbell | Wardrobe Supervisor |
| Camera | Francis Kenny | Camera Operator |
| Lighting | James Fitzpatrick | Gaffer |
| Sound | Lou Graf | Sound Editor |
| Sound | Bruce Kitzmeyer | Foley Editor |
| Sound | Louis Cerborino | Music Editor |
| Sound | Stuart Stanley | Assistant Sound Editor |
| Sound | Jay Dranch | ADR Editor |
| Sound | Randall Coleman | Assistant Sound Editor |
| Sound | Kenton Jakub | Assistant Sound Editor |
| Sound | Brunilda Torres | Assistant Sound Editor |
| Production | Julie Lamm | Post Production Accountant |
| Crew | Rocco Derasmo | Transportation Captain |
| Art | Santo Loquasto | Production Design |
| Production | Sarah Pillsbury | Producer |
| Costume & Make-Up | Werner Sherer | Hairstylist |
| Costume & Make-Up | Richard Dean | Makeup Artist |
| Directing | Ira Hurvitz | Script Supervisor |
| Sound | Timothy R. Sexton | Music Supervisor |
| Production | Michael Peyser | Unit Production Manager |
| Production | Risa Bramon Garcia | Casting |
| Editing | Andrew Mondshein | Editor |
| Sound | Thomas Newman | Original Music Composer |
| Production | Midge Sanford | Producer |
| Production | Michael Peyser | Executive Producer |
| Production | Billy Hopkins | Casting |
| Sound | Danny Goldberg | Music Supervisor |
| Art | George DeTitta Jr. | Set Decoration |
| Camera | Edward Lachman | Director of Photography |
| Sound | Maurice Schell | Supervising Sound Editor |
| Sound | Les Lazarowitz | Sound Mixer |
| Camera | Andrew D. Schwartz | Still Photographer |
| Camera | Mitch Dubin | First Assistant Camera |
