Wesley Gibson slijt zijn troosteloze bestaan in een benauwde kantoortuin, met een baas die hem vernedert en een vriendinnetje dat hem bedriegt. Zijn leven is een puinhoop. Dan ontdekt Wesley dat de vader, die hij nooit heeft gekend, op brutale wijze vermoord is en sluit hij zich, tegen wil en dank, aan bij een geheim genootschap van sluipmoordenaars: De Broederschap. Tijdens zijn opleiding door zijn getalenteerde mentor Fox, ontpopt de saaie kantoorpiet zich tot een moordwapen met bliksemsnelle reflexen en een bovenmenselijke behendigheid. Bij het aanvaarden van zijn eerste missie ontdekt Wesley echter nog iets anders: iemand van het leven beroven is niet makkelijk, maar je eigen leven weer in handen nemen is nog een stuk moeilijker.
| Camera | Mitchell Amundsen | Director of Photography |
| Editing | David Brenner | Editor |
| Production | Adam Siegel | Executive Producer |
| Production | Iain Smith | Producer |
| Art | John Myhre | Production Design |
| Production | Jeff Kirschenbaum | Executive Producer |
| Sound | Danny Elfman | Original Music Composer |
| Production | Roger Birnbaum | Executive Producer |
| Production | Jim Lemley | Producer |
| Writing | Chris Morgan | Screenplay |
| Production | Gary Barber | Executive Producer |
| Production | Geyer Kosinski | Executive Producer |
| Writing | Derek Haas | Screenplay |
| Writing | Michael Brandt | Screenplay |
| Production | Marc Silvestri | Executive Producer |
| Production | Jason Netter | Producer |
| Directing | Тимур Бекмамбетов | Director |
| Crew | Samantha MacIvor | Stunts |
| Camera | Rick James | Camera Trainee |
| Writing | Mark Millar | Comic Book |
| Writing | J.G. Jones | Comic Book |
| Costume & Make-Up | Stanislava Šlosserová | Costume Supervisor |
| Production | Mindy Marin | Casting |
| Art | Richard Roberts | Set Decoration |
| Costume & Make-Up | Varvara Avdyushko | Costume Design |
| Art | Patrick M. Sullivan | Art Direction |
| Art | David Baxa | Art Direction |
| Art | Martin Vačkář | Art Direction |
| Costume & Make-Up | Giovanni Casalnuovo | Costume Supervisor |
| Directing | Luc Etienne | First Assistant Director |
| Art | Allan M. Fleischmann | Set Designer |
| Editing | Dallas Puett | Additional Editing |
| Costume & Make-Up | Adéla Robová | Makeup Artist |
| Crew | C.C. Smiff | Fight Choreographer |
| Production | Jared LeBoff | Co-Producer |
| Visual Effects | Juliette Yager | Visual Effects Producer |
| Editing | Samuel Craven | Additional Editing |
| Costume & Make-Up | Linda de Vetta | Makeup Artist |
| Crew | Nick Gillard | Stunt Coordinator |
| Art | Steven M. Saylor | Set Designer |
| Production | Sally French | Unit Production Manager |
| Costume & Make-Up | Carmel Jackson | Makeup Artist |
| Crew | Martin Hub | Stunt Coordinator |
| Production | Sally French | Co-Producer |
| Art | Katerina Koutská | Set Designer |
| Visual Effects | Jon Farhat | Visual Effects Supervisor |
| Art | David Vondrasek | Set Designer |
| Costume & Make-Up | Nancy Hancock | Makeup Artist |
| Directing | Дмитрий Киселёв | Second Unit Director |
| Costume & Make-Up | Gregory B. Peña | Costume Supervisor |
| Crew | Mic Rodgers | Stunt Coordinator |
| Art | Bara Bucherova | Assistant Set Decoration |
| Art | Frantisek Weber | Set Designer |
| Costume & Make-Up | Julie Dartnell | Makeup Artist |
| Directing | Lori Wyant | Script Supervisor |
| Crew | Rick LeFevour | Stunt Coordinator |
| Costume & Make-Up | Frances Hannon | Makeup Designer |
| Costume & Make-Up | Gemma Richards | Makeup Artist |
| Visual Effects | Stefen Fangmeier | Visual Effects Supervisor |
| Production | Marc Platt | Producer |
| Visual Effects | Craig Lyn | Visual Effects Supervisor |
| Camera | George Richmond | Camera Operator |
| Camera | George Richmond | Steadicam Operator |
| Camera | John Toll | Additional Photography |
| Crew | Debbie Evans | Stunt Driver |
| Crew | Jophery C. Brown | Stunts |
| Visual Effects | Роман Дрягалин | Compositing Artist |
| Crew | Henry Kingi | Stunts |
| Crew | Freddie Hice | Stunts |
| Art | Tomas Voth | Supervising Art Director |
| Crew | Laura Albert | Stunts |
| Directing | Mic Rodgers | Second Unit Director |
| Crew | Chris Cenatiempo | Stunt Driver |
| Crew | Frank Ferrara | Stunt Driver |
| Costume & Make-Up | Adéla Robová | Hairstylist |
| Crew | John C. Meier | Stunts |
| Crew | Chris Barnes | Stunt Double |
| Crew | Veronika Bellová | Stunt Double |
| Crew | Riley Harper | Stunt Double |
| Costume & Make-Up | Carmel Jackson | Hairstylist |
| Costume & Make-Up | Gemma Richards | Hairstylist |
| Costume & Make-Up | René Stejskal | Makeup Designer |
| Crew | John D. Milinac | Special Effects Coordinator |
| Crew | Jennifer Lamb | Stunts |
| Crew | Cort Hessler | Stunt Driver |
| Costume & Make-Up | Frances Hannon | Hair Designer |
| Crew | James M. Halty | Stunts |
| Crew | Thomas Robinson Harper | Stunts |
| Crew | Dean Bailey | Stunts |
| Crew | Gary Baxley | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Crew | Maurice Lee | Stunt Double |
| Crew | Linda Perlin | Stunt Driver |
| Costume & Make-Up | Julie Dartnell | Hairstylist |
| Crew | Jindřich Klaus | Stunts |
| Crew | Ivo Zubaty | Stunts |
| Crew | Dominic Tuohy | Special Effects |
| Crew | Kenny Alexander | Stunts |
| Crew | Roy Farfel | Stunt Driver |
| Crew | Billy D. Lucas | Stunts |
| Crew | Eunice Huthart | Stunt Double |
| Crew | Jeff Shannon | Stunt Double |
| Crew | Roman Spacil | Stunts |
| Crew | Jason Rodriguez | Utility Stunts |
| Crew | Michael Runyard | Stunts |
| Crew | Mark Henson | Stunts |
| Crew | Leo Stransky | Stunt Double |
| Crew | Keith Woulard | Stunts |
| Crew | Rudolf Vrba | Stunt Double |
| Crew | Keith Tellez | Stunts |
| Crew | Leonard Woodcock | Stunts |
| Crew | Scott Workman | Stunt Driver |
| Crew | Kevin Sorensen | Stunts |
| Crew | Richard C. Taylor | Utility Stunts |
| Crew | Ross A. Jordan | Stunt Driver |
| Crew | Carl Paoli | Stunt Driver |
| Crew | Tim Trella | Stunts |
| Crew | Greg Tracy | Stunts |
| Crew | Jaroslav Peterka | Stunts |
| Crew | Alicia Skirball | Stunt Double |
| Crew | Todd Rogers Terry | Stunts |
| Crew | Danny Wynands | Stunts |
| Sound | Chris Jenkins | Sound Re-Recording Mixer |
| Sound | Wylie Stateman | Supervising Sound Editor |
| Sound | Frank A. Montaño | Sound Re-Recording Mixer |
| Sound | Petr Forejt | Production Sound Mixer |
| Crew | Rudra Banerji | Set Production Assistant |
| Art | Chris Cleek | Assistant Art Director |
