Wesley Gibson slijt zijn troosteloze bestaan in een benauwde kantoortuin, met een baas die hem vernedert en een vriendinnetje dat hem bedriegt. Zijn leven is een puinhoop. Dan ontdekt Wesley dat de vader, die hij nooit heeft gekend, op brutale wijze vermoord is en sluit hij zich, tegen wil en dank, aan bij een geheim genootschap van sluipmoordenaars: De Broederschap. Tijdens zijn opleiding door zijn getalenteerde mentor Fox, ontpopt de saaie kantoorpiet zich tot een moordwapen met bliksemsnelle reflexen en een bovenmenselijke behendigheid. Bij het aanvaarden van zijn eerste missie ontdekt Wesley echter nog iets anders: iemand van het leven beroven is niet makkelijk, maar je eigen leven weer in handen nemen is nog een stuk moeilijker.
| Camera | Mitchell Amundsen | Director of Photography |
| Production | Jim Lemley | Producer |
| Production | Jason Netter | Producer |
| Production | Iain Smith | Producer |
| Writing | Derek Haas | Screenplay |
| Writing | Michael Brandt | Screenplay |
| Writing | Chris Morgan | Screenplay |
| Editing | David Brenner | Editor |
| Art | John Myhre | Production Design |
| Production | Roger Birnbaum | Executive Producer |
| Production | Gary Barber | Executive Producer |
| Production | Jeff Kirschenbaum | Executive Producer |
| Production | Geyer Kosinski | Executive Producer |
| Production | Adam Siegel | Executive Producer |
| Production | Marc Silvestri | Executive Producer |
| Sound | Danny Elfman | Original Music Composer |
| Directing | Тимур Бекмамбетов | Director |
| Crew | Samantha MacIvor | Stunts |
| Camera | Rick James | Camera Trainee |
| Writing | Mark Millar | Comic Book |
| Writing | J.G. Jones | Comic Book |
| Production | Mindy Marin | Casting |
| Art | David Baxa | Art Direction |
| Art | Patrick M. Sullivan | Art Direction |
| Art | Martin Vačkář | Art Direction |
| Art | Richard Roberts | Set Decoration |
| Costume & Make-Up | Varvara Avdyushko | Costume Design |
| Costume & Make-Up | Giovanni Casalnuovo | Costume Supervisor |
| Costume & Make-Up | Stanislava Šlosserová | Costume Supervisor |
| Production | Sally French | Unit Production Manager |
| Production | Sally French | Co-Producer |
| Directing | Luc Etienne | First Assistant Director |
| Crew | Mic Rodgers | Stunt Coordinator |
| Crew | Nick Gillard | Stunt Coordinator |
| Crew | Martin Hub | Stunt Coordinator |
| Crew | Rick LeFevour | Stunt Coordinator |
| Crew | C.C. Smiff | Fight Choreographer |
| Production | Jared LeBoff | Co-Producer |
| Visual Effects | Stefen Fangmeier | Visual Effects Supervisor |
| Visual Effects | Jon Farhat | Visual Effects Supervisor |
| Visual Effects | Juliette Yager | Visual Effects Producer |
| Art | Bara Bucherova | Assistant Set Decoration |
| Art | Katerina Koutská | Set Designer |
| Art | David Vondrasek | Set Designer |
| Art | Frantisek Weber | Set Designer |
| Art | Steven M. Saylor | Set Designer |
| Art | Allan M. Fleischmann | Set Designer |
| Editing | Dallas Puett | Additional Editing |
| Editing | Samuel Craven | Additional Editing |
| Costume & Make-Up | Gregory B. Peña | Costume Supervisor |
| Costume & Make-Up | Frances Hannon | Makeup Designer |
| Costume & Make-Up | Julie Dartnell | Makeup Artist |
| Costume & Make-Up | Carmel Jackson | Makeup Artist |
| Costume & Make-Up | Gemma Richards | Makeup Artist |
| Costume & Make-Up | Adéla Robová | Makeup Artist |
| Costume & Make-Up | Nancy Hancock | Makeup Artist |
| Costume & Make-Up | Linda de Vetta | Makeup Artist |
| Directing | Lori Wyant | Script Supervisor |
| Directing | Дмитрий Киселёв | Second Unit Director |
| Production | Marc Platt | Producer |
| Visual Effects | Craig Lyn | Visual Effects Supervisor |
| Camera | George Richmond | Camera Operator |
| Camera | George Richmond | Steadicam Operator |
| Camera | John Toll | Additional Photography |
| Crew | Debbie Evans | Stunt Driver |
| Crew | Jophery C. Brown | Stunts |
| Visual Effects | Роман Дрягалин | Compositing Artist |
| Crew | Henry Kingi | Stunts |
| Crew | Freddie Hice | Stunts |
| Art | Tomas Voth | Supervising Art Director |
| Crew | Laura Albert | Stunts |
| Directing | Mic Rodgers | Second Unit Director |
| Costume & Make-Up | René Stejskal | Makeup Designer |
| Costume & Make-Up | Frances Hannon | Hair Designer |
| Costume & Make-Up | Carmel Jackson | Hairstylist |
| Costume & Make-Up | Julie Dartnell | Hairstylist |
| Costume & Make-Up | Adéla Robová | Hairstylist |
| Costume & Make-Up | Gemma Richards | Hairstylist |
| Crew | John D. Milinac | Special Effects Coordinator |
| Crew | Dominic Tuohy | Special Effects |
| Crew | Dean Bailey | Stunts |
| Crew | Chris Barnes | Stunt Double |
| Crew | Kenny Alexander | Stunts |
| Crew | Veronika Bellová | Stunt Double |
| Crew | Chris Cenatiempo | Stunt Driver |
| Crew | Gary Baxley | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Crew | Roy Farfel | Stunt Driver |
| Crew | Frank Ferrara | Stunt Driver |
| Crew | James M. Halty | Stunts |
| Crew | Thomas Robinson Harper | Stunts |
| Crew | Cort Hessler | Stunt Driver |
| Crew | Jennifer Lamb | Stunts |
| Crew | Ross A. Jordan | Stunt Driver |
| Crew | Maurice Lee | Stunt Double |
| Crew | Billy D. Lucas | Stunts |
| Crew | John C. Meier | Stunts |
| Crew | Carl Paoli | Stunt Driver |
| Crew | Jason Rodriguez | Utility Stunts |
| Crew | Michael Runyard | Stunts |
| Crew | Linda Perlin | Stunt Driver |
| Crew | Jaroslav Peterka | Stunts |
| Crew | Eunice Huthart | Stunt Double |
| Crew | Jindřich Klaus | Stunts |
| Crew | Riley Harper | Stunt Double |
| Crew | Franklin Mark Henson | Stunts |
| Crew | Alicia Skirball | Stunt Double |
| Crew | Jeff Shannon | Stunt Double |
| Crew | Roman Spacil | Stunts |
| Crew | Kevin Sorensen | Stunts |
| Crew | Leo Stransky | Stunt Double |
| Crew | Richard C. Taylor | Utility Stunts |
| Crew | Keith Tellez | Stunts |
| Crew | Tim Trella | Stunts |
| Crew | Leonard Woodcock | Stunts |
| Crew | Todd Rogers Terry | Stunts |
| Crew | Scott Workman | Stunt Driver |
| Crew | Keith Woulard | Stunts |
| Crew | Greg Tracy | Stunts |
| Crew | Rudolf Vrba | Stunt Double |
| Crew | Ivo Zubaty | Stunts |
| Crew | Danny Wynands | Stunts |
| Sound | Wylie Stateman | Supervising Sound Editor |
| Sound | Chris Jenkins | Sound Re-Recording Mixer |
| Sound | Frank A. Montaño | Sound Re-Recording Mixer |
| Sound | Petr Forejt | Production Sound Mixer |
| Crew | Rudra Banerji | Set Production Assistant |
| Art | Chris Cleek | Assistant Art Director |
| Camera | Jay Maidment | Additional Set Photographer |
