Een 'spin-off' van de film 'Knocked Up', die een kijkje geeft in het leven van Pete en Debbie. Ze zijn inmiddels ouder geworden en er is een hoop gebeurd. Voor hun inkomsten zijn ze afhankelijk van Debbie's kledingwinkel. Ze lopen daarnaast rond met de grote vragen des levens. "Hebben ze wel de juiste keuzes gemaakt?" "Is dit hun plaats in de wereld?" En: "Is dit nu echt alles?" Alle dromen die zij hadden als kind, alle mogelijkheden, is dat nu verpest door een simpel huwelijk en het nemen van wat kinderen?
Nee, helaas is This Is 40 nog niet beschikbaar op Netflix in Nederland.
| Directing | Judd Apatow | Director |
| Production | Judd Apatow | Producer |
| Production | Clayton Townsend | Producer |
| Production | Barry Mendel | Producer |
| Writing | Judd Apatow | Screenplay |
| Sound | Jon Brion | Original Music Composer |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | Joe Bucaro III | Stunt Double |
| Crew | Tom Elliott | Stunt Driver |
| Costume & Make-Up | Leesa Evans | Costume Design |
| Art | Leslie A. Pope | Set Decoration |
| Art | Jefferson Sage | Production Design |
| Art | Andrew Max Cahn | Art Direction |
| Production | Allison Jones | Casting |
| Directing | Valeria Migliassi Collins | Script Supervisor |
| Crew | Joel Kramer | Stunt Coordinator |
| Sound | Ken McLaughlin | Production Sound Mixer |
| Sound | George H. Anderson | Supervising Sound Editor |
| Sound | Adam Jenkins | Sound Re-Recording Mixer |
| Sound | Marc Fishman | Sound Re-Recording Mixer |
| Sound | Cindy Marty | Sound Effects Editor |
| Production | Paula Pell | Executive Producer |
| Production | Lisa Goldberg | Co-Producer |
| Camera | Suzanne Hanover | Still Photographer |
| Camera | Phedon Papamichael | Director of Photography |
| Editing | Brent White | Editor |
| Editing | Jay Deuby | Editor |
| Sound | Jonathan Karp | Music Supervisor |
| Editing | David L. Bertman | Editor |
| Production | Barrett J. Leigh | Production Supervisor |
| Camera | David Luckenbach | Steadicam Operator |
| Camera | David Luckenbach | Camera Operator |
| Costume & Make-Up | Dan Bronson | Costume Supervisor |
| Art | Erin E. Riegel | Art Department Assistant |
| Crew | Debbie Evans | Stunt Driver |
| Crew | Lois Yaroshefsky | Studio Teacher |
| Crew | Riley Harper | Stunts |
| Sound | Tammy Fearing | ADR Supervisor |
| Sound | James Matheny | Dialogue Editor |
| Sound | Larry Kemp | Dialogue Editor |
| Costume & Make-Up | Linda Arnold | Hair Department Head |
| Directing | Joel Kramer | Second Unit Director |
| Directing | Matt Rebenkoff | First Assistant Director |
| Art | Sean Mannion | Property Master |
| Crew | Dick Ziker | Stunt Driver |
| Costume & Make-Up | Ed French | Makeup Artist |
| Costume & Make-Up | Valli O'Reilly | Makeup Artist |
| Costume & Make-Up | Amy Lederman | Makeup Artist |
| Costume & Make-Up | Beth O'Rourke | Makeup Artist |
| Costume & Make-Up | Viola Rock | Makeup Artist |
| Costume & Make-Up | Kimberly Greene | Makeup Department Head |
| Costume & Make-Up | Erin Wooldridge | Key Makeup Artist |
| Costume & Make-Up | Michael Moore | Key Hair Stylist |
| Costume & Make-Up | Tammy Kusian | Hairstylist |
| Costume & Make-Up | Donna J. Anderson | Hairstylist |
| Directing | Paul Schneider | Second Assistant Director |
| Crew | Donald Frazee | Special Effects Coordinator |
| Visual Effects | Scott M. Davids | Visual Effects Supervisor |
| Crew | Colin Follenweider | Stunt Double |
| Crew | Jack Carpenter | Stunts |
| Crew | Wally Crowder | Stunts |
| Crew | Steve Hart | Stunt Driver |
| Crew | Paul M. Lane | Stunt Driver |
| Crew | Scott Leva | Stunts |
| Crew | Norman Howell | Stunts |
| Crew | Jody Millard | Stunt Double |
| Crew | Ed McDermott II | Stunt Driver |
| Crew | Stephen W. Schriver | Stunt Driver |
| Crew | Tierre Turner | Stunt Driver |
| Crew | Mark Aaron Wagner | Stunt Double |
| Camera | John R. Leonetti | Second Unit Director of Photography |
| Camera | Goran Pavicevic | Second Unit Director of Photography |
| Crew | Danny Teeson | Choreographer |
| Costume & Make-Up | Clinton Wayne | Prosthetic Designer |
| Production | Angel Cook | Production Assistant |
