Derek Zoolander, een succesvol mannelijk model, komt er op een dag achter dat zijn beste dagen in het vak achter zich liggen. Al een aantal jaren is hij uitgeroepen tot Male Model of the Year, maar dan gaat de felbegeerde titel opeens naar nieuwkomer Hansel. Dan wordt Derek benaderd door een zekere Mugatu die hem perspectieven biedt voor een nieuwe loopbaan.
| Directing | Ben Stiller | Director |
| Writing | Drake Sather | Characters |
| Writing | Ben Stiller | Characters |
| Writing | Drake Sather | Screenplay |
| Writing | Ben Stiller | Screenplay |
| Writing | John Hamburg | Screenplay |
| Production | Stuart Cornfeld | Producer |
| Production | Joel Gallen | Executive Producer |
| Production | Scott Rudin | Producer |
| Production | Adam Schroeder | Executive Producer |
| Production | Ben Stiller | Producer |
| Production | Lauren Zalaznick | Executive Producer |
| Sound | David Arnold | Original Music Composer |
| Camera | Barry Peterson | Director of Photography |
| Editing | Greg Hayden | Editor |
| Art | Peter C. Clarke | Property Master |
| Sound | Frank Smathers | Dialogue Editor |
| Production | Celia D. Costas | Co-Producer |
| Production | Monica Levinson | Associate Producer |
| Production | Juel Bestrop | Casting |
| Production | Kathleen Chopin | Casting |
| Production | Jeanne McCarthy | Casting |
| Sound | George Drakoulias | Music Supervisor |
| Sound | Randall Poster | Music Supervisor |
| Art | Robin Standefer | Production Design |
| Costume & Make-Up | David C. Robinson | Costume Design |
| Production | Dennis Widmyer | Art Department Production Assistant |
| Art | Stephen Alesch | Art Direction |
| Art | Donna Hamilton | Set Decoration |
| Art | Melody Bishop | Art Department Coordinator |
| Art | Kyung W. Chang | Assistant Art Director |
| Art | Fred Merusi | Construction Coordinator |
| Art | Richard Boris | Greensman |
| Art | Guy Efrat | Location Scout |
| Art | Aric Lasher | Set Designer |
| Camera | Gerard Sava | Additional Camera |
| Camera | Clyde W. Smith | Additional Photography |
| Camera | Patrick Capone | Camera Operator |
| Camera | Sam DiMaggio | First Assistant Camera |
| Camera | David Norris | Helicopter Camera |
| Camera | Dan Kneece | Steadicam Operator |
| Camera | François Duhamel | Still Photographer |
| Costume & Make-Up | Frank L. Fleming | Assistant Costume Designer |
| Costume & Make-Up | Joanna Brett | Costume Supervisor |
| Costume & Make-Up | Alan D'Angerio | Hair Designer |
| Costume & Make-Up | Catherine Childers | Hairstylist |
| Costume & Make-Up | Kate Biscoe | Makeup Artist |
| Costume & Make-Up | Naomi Donne | Makeup Designer |
| Costume & Make-Up | Joseph La Corte | Set Costumer |
| Costume & Make-Up | Jessica Marshall | Wigmaker |
| Crew | Randy Kerber | Additional Music |
| Crew | Scott Gertsen | Carpenter |
| Crew | Joey McKneely | Choreographer |
| Crew | Kendra Levenberg | Craft Service |
| Crew | Jim Dolson | Scenic Artist |
| Crew | Fortunato Frattasio | Sequence Supervisor |
| Crew | Maureen Beitler | Set Medic |
| Crew | John C. Hartigan | Special Effects Coordinator |
| Crew | LeJon Stewart | Stand In |
| Crew | Brad Martin | Stunt Coordinator |
| Crew | Clayton J. Barber | Stunts |
| Crew | Mitch Goldstrom | Systems Administrators & Support |
| Crew | Guy Merrick | Transportation Co-Captain |
| Crew | Michael Merrick | Transportation Coordinator |
| Production | Celia D. Costas | Unit Production Manager |
| Crew | Eric Myers | Unit Publicist |
| Crew | Joel Holland | Video Assist Operator |
| Directing | Eva Z. Cabrera | Script Supervisor |
| Editing | Dennis McNeill | Color Timer |
| Lighting | Kelly Connors | Electrician |
| Lighting | Robert Anderson | Rigging Grip |
| Production | Blythe Cappello | Casting Associate |
| Production | Jerry Jaffe | Location Manager |
| Production | Maggie Kusik | Production Accountant |
| Production | Lizz Grant | Production Coordinator |
| Sound | Perry Dodgson | Boom Operator |
| Sound | Dan Blazi | First Assistant Sound Editor |
| Sound | Harold Burke | Foley |
| Sound | Jonathan Karp | Music Editor |
| Sound | Nicholas Dodd | Orchestrator |
| Sound | Danny Michael | Production Sound Mixer |
| Sound | Yann Delpuech | Sound Editor |
| Sound | Christopher Emerson | Sound Effects Editor |
| Sound | David Kirschner | Sound Mixer |
| Sound | Robert Grieve | Supervising Sound Editor |
| Visual Effects | Don Lee | Digital Compositors |
| Visual Effects | Walter Garcia | Visual Effects Coordinator |
| Visual Effects | Carole Cowley | Visual Effects Producer |
| Visual Effects | David D. Johnson | Visual Effects Supervisor |
| Sound | Thom 'Coach' Ehle | Dolby Consultant |
| Sound | Bill Meadows | Sound Recordist |
| Camera | Caesar S. Carnevale | Camera Loader |
| Crew | Joanne Lamstein | Stunt Double |
| Art | Patrick Denver | Special Props |
| Directing | Amy Sayres | First Assistant Director |
| Costume & Make-Up | Karen Dahl | Makeup Artist |
| Costume & Make-Up | Chris Ann Pappas | Costume Assistant |
| Costume & Make-Up | Monica Ruiz-Ziegler | Costume Coordinator |
| Costume & Make-Up | Sandi Figueroa | Costumer |
| Directing | Maggie Murphy | Second Assistant Director |
| Directing | Bradley Morris | Second Second Assistant Director |
| Art | Russ J. Griffon | Assistant Property Master |
| Art | Richard Hebrank | Construction Grip |
| Art | John Davis | Storyboard Artist |
| Art | Kyle Cooper | Title Designer |
| Sound | Joel Shryack | ADR Editor |
| Sound | Bob Baron | ADR Mixer |
| Sound | Hilda Hodges | Foley Artist |
| Sound | Shawn Kennelly | Foley Mixer |
| Visual Effects | Lawrence Carroll | Visual Effects Compositor |
| Crew | Barry Williams | Visual Effects Editor |
| Visual Effects | Jeffrey Caruso | Visual Effects Production Assistant |
| Crew | Donald John Hewitt | Stunt Double |
| Camera | Paul Candrilli | Dolly Grip |
| Camera | Mitchell Andrew Lillian | First Company Grip |
| Camera | Amanda Hudson | Second Assistant Camera |
| Camera | Alexander Griffiths | Second Company Grip |
| Production | Nadia Lubbe Simon | Casting Assistant |
| Editing | Kent Blocher | Assistant Editor |
| Editing | Mary Nelson-Duerrstein | Negative Cutter |
| Production | Linda 'Sam' Glynn | Assistant Location Manager |
| Sound | Nicholas Dodd | Conductor |
| Production | Edward E. Giddens | Assistant Accountant |
| Lighting | Ron Alexus | Assistant Chief Lighting Technician |
| Production | Matthew Spiegel | Assistant Production Coordinator |
| Crew | Joseph Garzero | Charge Scenic Artist |
| Lighting | Jay Fortune | Chief Lighting Technician |
| Production | Edith Hagigi | Executive Assistant |
| Production | Sylvia Fay | Extras Casting |
| Production | Rick Tropasso | First Assistant Accountant |
| Lighting | Roy Bennett | Lighting Design |
| Production | Adeline Colangelo | Production Assistant |
| Production | Jose Cabrera | Production Secretary |
| Production | Michelle Dunton | Script Researcher |
| Crew | Wayne Petrucelli | Security Coordinator |
| Writing | Narges Takesh | Story Editor |
| Camera | Melinda Sue Gordon | Still Photographer |
| Art | Wayne Brackett | Set Dresser |
