De rechercheurs Martin Riggs, Roger Murtaugh en Lorna Cole zijn terug, samen met de hyperactieve Leo Getz. Het viertal wordt ditmaal bijgestaan door assistent-rechercheur Lee Butters in hun onderzoek naar de mensensmokkel die georganiseerd wordt door een Aziatische misdaadorganisatie. Ze worden al snel geconfronteerd met Wan Sing Ku, de harde man in de organisatie. Dan blijkt al snel dat het oprollen van deze Chinese maffia-bende een zware, dodelijke klus zou kunnen worden voor Riggs en Murtaugh.
Nee, helaas is Lethal Weapon 4 nog niet beschikbaar op Netflix in Nederland.
| Production | Joel Silver | Producer |
| Directing | Richard Donner | Director |
| Production | Richard Donner | Producer |
| Camera | Andrzej Bartkowiak | Director of Photography |
| Art | J. Michael Riva | Production Design |
| Art | Richard F. Mays | Art Direction |
| Sound | Eric Clapton | Original Music Composer |
| Sound | David Sanborn | Original Music Composer |
| Editing | Dallas Puett | Editor |
| Editing | Frank J. Urioste | Editor |
| Writing | Channing Gibson | Screenplay |
| Art | David F. Klassen | Art Direction |
| Art | Lauri Gaffin | Set Decoration |
| Costume & Make-Up | Ha Nguyen | Costume Design |
| Sound | Michael Kamen | Original Music Composer |
| Editing | Eric Strand | Editor |
| Production | Marion Dougherty | Casting |
| Editing | Kevin Stitt | Editor |
| Sound | Lou Kleinman | Sound Effects Editor |
| Crew | Billy D. Lucas | Stunts |
| Crew | Danny Epper | Stunts |
| Crew | Mic Rodgers | Stunt Coordinator |
| Crew | Kenny Endoso | Stunts |
| Crew | Michael Runyard | Stunts |
| Production | Steve Perry | Executive Producer |
| Production | Jim Van Wyck | Executive Producer |
| Crew | Al Goto | Stunts |
| Crew | Tim Trella | Stunts |
| Writing | Alfred Gough | Story |
| Production | Spencer Franklin | Associate Producer |
| Writing | Shane Black | Characters |
| Writing | Miles Millar | Story |
| Production | J. Mills Goodloe | Co-Producer |
| Production | Ilyse A. Reutlinger | Associate Producer |
| Production | Jennifer Gwartz | Associate Producer |
| Production | Dan Cracchiolo | Co-Producer |
| Writing | Jonathan Lemkin | Story |
| Crew | Doc Duhame | Stunts |
| Crew | Michiko Nishiwaki | Stunts |
| Crew | Tommy J. Huff | Stunts |
| Crew | Lisa Hoyle | Stunts |
| Crew | Henry Kingi Jr. | Stunts |
| Crew | Patricia M. Peters | Stunts |
| Crew | Huan-Chiu Ku | Martial Arts Choreographer |
| Camera | Bobby Brown | First Assistant Camera |
| Crew | David Fencl | Armorer |
| Costume & Make-Up | Charlene Amateau | Set Costumer |
| Crew | Peter Roderick | Carpenter |
| Sound | Ezra Dweck | Foley Editor |
| Sound | Mark Mangini | Supervising Sound Editor |
| Costume & Make-Up | Kareen Boursier | Hairstylist |
| Costume & Make-Up | Jeff Hay | Set Dressing Artist |
| Camera | Robert Ikeda | Grip |
| Costume & Make-Up | Charlene Johnson | Key Hair Stylist |
| Crew | Frank Roughan | Transportation Captain |
| Directing | J. Tom Archuleta | First Assistant Director |
| Sound | Chris Boardman | Orchestrator |
| Visual Effects | David Taritero | Visual Effects Producer |
| Camera | Michael J. Coo | Key Grip |
| Crew | Ernest H. Lauterio | Craft Service |
| Camera | Bill Brummond | Steadicam Operator |
| Costume & Make-Up | Kimberly Guenther Durkin | Costume Supervisor |
| Crew | Ilyse A. Reutlinger | Post Production Supervisor |
| Camera | Pete Romano | Underwater Camera |
| Costume & Make-Up | Lisa Deveaux | Makeup Artist |
| Crew | Jerome Butler | Dialect Coach |
| Crew | Thomas S. Dickson | Projection |
| Art | Erik L. Nelson | Property Master |
| Camera | Steven J. Winslow | Camera Technician |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Crew | Gil Amaral | Driver |
| Camera | Andrew Cooper | Still Photographer |
| Editing | Dale E. Grahn | Color Timer |
| Crew | Jon G. Belyeu | Special Effects Coordinator |
| Sound | Mark Kenna | Dolby Consultant |
| Crew | Conrad E. Palmisano | Stunt Coordinator |
| Crew | John M. Woodward | Transportation Coordinator |
| Production | R. Anthony Brown | Unit Production Manager |
| Lighting | Scott Kidner | Lighting Technician |
| Sound | Baylis Glascock | Assistant Sound Editor |
| Sound | John Pospisil | Sound Designer |
| Crew | Andrew Lipschultz | Unit Publicist |
| Lighting | Richard Hartley | Rigging Gaffer |
| Lighting | Robert J. Reilly | Rigging Grip |
| Sound | Tim Cooney | Production Sound Mixer |
| Sound | Richard L. Anderson | Sound Effects Editor |
| Visual Effects | Cristin Pescosolido | Digital Compositors |
| Crew | Cory Fleming | Utility Stunts |
| Production | Thomas A. Davila | Production Accountant |
| Sound | Todd Bassman | Boom Operator |
| Visual Effects | Bill Maher | Visual Effects Coordinator |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Crew | Martin Glover | Video Assist Operator |
| Crew | Bruce Paul Barbour | Stunts |
| Lighting | Christian J. Killingsworth | Electrician |
| Crew | Laura Gary | Studio Teachers |
| Crew | Louis Farah | Set Medic |
| Lighting | Tasso Bravos | Best Boy Electric |
| Production | Douglas Wright | Casting Associate |
| Production | Michael Haro | Location Manager |
| Sound | Zigmund Gron | Music Editor |
| Art | Charisse Cardenas | Set Designer |
| Art | Bill 'Kauhane' Hoyt | Standby Painter |
| Camera | Ray De La Motte | Camera Operator |
| Art | Walt Hadfield | Construction Coordinator |
| Production | Geoff Johns | Co-Producer |
| Art | Carlo Basail | Greensman |
| Camera | Steve Adcock | Additional Camera |
| Art | Wendy Riva | Assistant Art Director |
| Art | Marc Baird | Production Illustrator |
| Art | James F. Walker | Construction Foreman |
| Crew | Norman Howell | Stunts |
| Crew | Cheryl Wheeler Duncan | Stunt Double |
| Crew | Erik Cord | Stunts |
| Crew | Troy Gilbert | Stunts |
| Crew | Tim Gilbert | Stunts |
| Crew | Jeff Imada | Stunts |
| Crew | Thomas Rosales Jr. | Stunts |
| Crew | Annie Ellis | Stunts |
| Crew | Jennifer Caputo | Stunts |
| Crew | Ronnie Rondell Jr. | Stunts |
| Sound | Gregg Rudloff | Sound Re-Recording Mixer |
| Crew | Henry Kingi | Stunts |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Marcus Miller | Additional Music |
| Sound | Marshall Winn | ADR Editor |
| Sound | Avram D. Gold | Supervising Dialogue Editor |
| Sound | Susan Dudeck | Dialogue Editor |
| Sound | William C. Carruth | ADR Editor |
| Directing | Conrad E. Palmisano | Second Unit Director |
| Sound | James Simcik | Supervising ADR Editor |
| Crew | Gary McLarty | Stunts |
| Crew | Lance Gilbert | Stunt Double |
| Directing | Mic Rodgers | Second Unit Director |
| Crew | Gregory J. Barnett | Stunts |
| Crew | John C. Meier | Stunts |
| Sound | Stephen McLaughlin | Music Score Producer |
| Crew | Buddy Joe Hooker | Stunts |
| Crew | Jill Brown | Stunts |
| Crew | Jimmy N. Roberts | Stunts |
| Sound | Eric Gotthelf | Foley Mixer |
| Camera | Christopher Blauvelt | Second Assistant Camera |
| Visual Effects | Dan Levitan | Compositing Supervisor |
| Sound | Carolyn Tapp | Foley Recordist |
| Production | Lisa Matsukawa | Production Secretary |
| Directing | David Ascher | Second Second Assistant Director |
| Sound | Troy Porter | ADR Mixer |
| Crew | Tom von Badinski | Special Effects Technician |
| Camera | Chris Bangma | Assistant Camera |
| Production | Cynthia Neber | Executive Assistant |
| Crew | Art Fransen | Technical Advisor |
| Production | Geoff Harding | Assistant Location Manager |
| Lighting | Stanley L. Gonsales | Assistant Chief Lighting Technician |
| Art | Christopher Amy | Assistant Property Master |
| Crew | Richard Castro | Special Effects Assistant |
| Editing | Jonathan Malden | Colorist |
| Camera | Jacobus Marcus | Camera Loader |
| Crew | Troy Brown | Stunt Double |
| Crew | Rick Sawaya | Stunt Driver |
| Camera | Nico Bally | Dolly Grip |
| Editing | Mo Henry | Negative Cutter |
| Production | Jason S. Gondek | Accountant |
| Production | Jodie Thomas | Production Assistant |
| Sound | Josephine Nericcio | Assistant Dialogue Editor |
| Sound | Michael Kamen | Conductor |
| Lighting | James B. Crawford | Chief Lighting Technician |
| Crew | Dick Hancock | Stunts |
| Crew | George Fisher | Stunts |
