FBI-agent Malcolm Turner is op jacht naar een ontsnapte bankrover die vermoedelijk naar het huis van Big Momma zal gaan, de grootmoeder van diens knappe ex-vriendin Sherry. Wanneer Big Momma plotseling op reis gaat, dreigt het plan te mislukken en is het aan Malcolm om de rol van de spraakmakende oma over te nemen. Malcolm heeft alles onder controle, behalve wanneer hij verliefd wordt op Sherry.
Nee, helaas is Big Momma's House nog niet beschikbaar op Netflix in Nederland.
| Writing | Darryl Quarles | Screenplay |
| Writing | Don Rhymer | Screenplay |
| Production | David T. Friendly | Producer |
| Production | Jeff Kwatinetz | Executive Producer |
| Production | Martin Lawrence | Executive Producer |
| Sound | Richard Gibbs | Original Music Composer |
| Camera | Michael D. O'Shea | Director of Photography |
| Editing | Kent Beyda | Editor |
| Editing | Bruce Green | Editor |
| Production | Michael Green | Producer |
| Directing | Richard Graves | First Assistant Director |
| Directing | Susan J. Hellmann | Second Assistant Director |
| Crew | Ernie F. Orsatti | Stunt Coordinator |
| Art | Randy Moore | Art Direction |
| Art | Ellen Totleben | Set Decoration |
| Camera | Jeff Case | Key Grip |
| Sound | Thomas Causey | Sound Mixer |
| Costume & Make-Up | Frank Perry Rose | Costume Supervisor |
| Art | David T. Cannon | Construction Coordinator |
| Crew | Billy G. Arter | Transportation Coordinator |
| Directing | Benita Brazier | Script Supervisor |
| Art | Rudy Reachi | Property Master |
| Crew | Larry Fioritto | Special Effects Coordinator |
| Sound | Robert Grieve | Supervising Sound Editor |
| Sound | Yann Delpuech | Supervising Sound Editor |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Art | Mariko Braswell | Set Designer |
| Art | Charisse Cardenas | Set Designer |
| Art | Kathleen Walker | Art Department Coordinator |
| Costume & Make-Up | Gary Archer | Prosthetics |
| Crew | David Leitch | Stunts |
| Production | Arnon Milchan | Executive Producer |
| Crew | Tony R. Medina | Propmaker |
| Costume & Make-Up | Todd Tucker | Special Effects Makeup Artist |
| Directing | Raja Gosnell | Director |
| Writing | Darryl Quarles | Story |
| Art | Craig Stearns | Production Design |
| Costume & Make-Up | Francine Jamison-Tanchuck | Costume Design |
| Production | Nancy Klopper | Casting |
