Nadat Alison Jones door een stom toeval hoort, dat haar aanstaande Sam met zijn ex-vrouw naar bed is geweest, wijst ze hem direct het gat van de deur. Dat betekent wel, dat ze vanaf dat moment alleen in een groot appartement in een nogal sinistere buurt. Allie besluit een advertentie te plaatsen voor een kamergenote. Hedra Carlson is een geschenk uit de hemel. Het ingetogen meisje is dankbaar voor de kamer die ze met Allie mag delen. Wel eist Hedy dat Sam in geen geval meer terug komt om haar plaats weer in te nemen, maar Allie stelt haar gerust. Meer en meer trekken de meisjes met elkaar op, totdat Allie onaangenaam verrast wordt door Hedy, die zich langzamerhand alle uiterlijke kenmerken van haar kamergenote gaat aanmeten. Dan komt Sam plotseling weer opdagen en dat bevalt Hedy niet. Voor Allie's ogen voltrekt zich een beangstigende verandering. De perfecte kamergenote wordt de huiveringwekkendste nachtmerrie.
Nee, helaas is Single White Female nog niet beschikbaar op Netflix in Nederland.
| Writing | Don Roos | Screenplay |
| Writing | John Lutz | Novel |
| Production | Barbet Schroeder | Producer |
| Production | Jack Baran | Executive Producer |
| Directing | Barbet Schroeder | Director |
| Camera | Luciano Tovoli | Director of Photography |
| Editing | Lee Percy | Editor |
| Sound | Howard Shore | Original Music Composer |
| Editing | Sarah Peddie | Assistant Editor |
| Camera | Monty Rowan | Camera Operator |
| Camera | Brian LeGrady | Second Assistant Camera |
| Crew | Eddie Surkin | Special Effects |
| Sound | Carl Fischer | Boom Operator |
| Directing | Daniel R. Suhart | Second Assistant Director |
| Sound | Christopher Boyes | Assistant Sound Designer |
| Crew | Jamie Jo Medearis | Stunts |
| Costume & Make-Up | Elisabetta Beraldo | Assistant Costume Designer |
| Costume & Make-Up | Jaqueline De La Fontaine | Costumer |
| Camera | Bob Hall | First Assistant Camera |
| Lighting | Mike Moyer | Chief Lighting Technician |
| Sound | Ken Fischer | Sound Editor |
| Sound | J.R. Grubbs | Assistant Sound Editor |
| Production | Roger Joseph Pugliese | Unit Production Manager |
| Production | Elyse Katz | Production Coordinator |
| Sound | Claire Sanfilippo | Assistant Sound Editor |
| Lighting | David Burnett | Assistant Chief Lighting Technician |
| Sound | Tom Myers | Assistant Sound Designer |
| Art | Robert Dawson | Title Designer |
| Camera | Gary Dagg | Key Grip |
| Sound | Gwendolyn Yates Whittle | Sound Editor |
| Crew | Beverly Walker | Unit Publicist |
| Costume & Make-Up | Eileen Kennedy | Costume Supervisor |
| Art | James F. Walker | Construction Foreman |
| Sound | Gary Rydstrom | Sound Re-Recording Mixer |
| Camera | Joe Kelly | Best Boy Grip |
| Crew | Edward J. Ulrich | Stunt Coordinator |
| Art | Walt Hadfield | Construction Coordinator |
| Crew | Joni Avery | Stunts |
| Sound | Gloria S. Borders | Supervising Sound Editor |
| Sound | Tom Johnson | Sound Re-Recording Mixer |
| Camera | David Nims | Dolly Grip |
| Production | Margaret Mitchell | Production Accountant |
| Sound | Marilyn McCoppen | Sound Editor |
| Art | James F. Truesdale | Assistant Art Director |
| Editing | Emily Wallin | Assistant Editor |
| Sound | Don Hall | Sound Editor |
| Sound | Ethan Van der Ryn | Sound Editor |
| Sound | Gary Rydstrom | Sound Designer |
| Sound | E. Jeane Putnam | Sound Editor |
| Sound | Jim Weidman | Music Editor |
| Sound | Richard Beggs | Sound Re-Recording Mixer |
| Camera | François Duhamel | Still Photographer |
| Crew | Tom Briggs | Transportation Coordinator |
| Directing | Wilma Garscadden-Gahret | Script Supervisor |
| Production | Jakki Fink | Casting Assistant |
| Art | Douglas E. Maxwell | Leadman |
| Sound | Tim Holland | Supervising Sound Editor |
| Sound | Robert Shoup | Sound Editor |
| Crew | James Brown | Transportation Captain |
| Costume & Make-Up | Matthew W. Mungle | Special Effects Makeup Artist |
| Art | Milena Canonero | Production Design |
| Art | Anne H. Ahrens | Set Decoration |
| Production | Roger Joseph Pugliese | Co-Producer |
| Production | Howard Feuer | Casting |
| Costume & Make-Up | Lizbeth Williamson | Makeup Artist |
| Production | Susan Hoffman | Associate Producer |
| Art | P. Michael Johnston | Art Direction |
| Costume & Make-Up | Milena Canonero | Costume Design |
| Costume & Make-Up | Candace Neal | Hairstylist |
