Twee vrienden, de slimme George en de simpele, maar sterke Lennie, reizen tijdens de depressie van de jaren '20 door het Amerikaanse platteland, dromend van een beter leven. Ze krijgen ergens werk, maar raken in de problemen als Lennie in een incident met een meisje verwikkeld raakt.
Nee, helaas is Of Mice and Men nog niet beschikbaar op Netflix in Nederland.
| Writing | John Steinbeck | Novel |
| Production | Gary Sinise | Producer |
| Production | Russell Smith | Producer |
| Production | Alan C. Blomquist | Executive Producer |
| Camera | Kenneth MacMillan | Director of Photography |
| Writing | Horton Foote | Screenplay |
| Sound | Mark Isham | Original Music Composer |
| Directing | Gary Sinise | Director |
| Editing | Robert L. Sinise | Editor |
| Production | Alan C. Blomquist | Unit Production Manager |
| Sound | John Phillips | Supervising Sound Editor |
| Art | Dan Davis | Art Direction |
| Crew | Howard Jensen | Special Effects |
| Art | Joyce Anne Gilstrap | Set Decoration |
| Directing | Michele Panelli-Venetis | Second Assistant Director |
| Costume & Make-Up | Bonita DeHaven | Makeup Artist |
| Costume & Make-Up | Ann Pala | Assistant Makeup Artist |
| Directing | Cara Giallanza | First Assistant Director |
| Costume & Make-Up | Peggy Hannaman | Assistant Hairstylist |
| Costume & Make-Up | Fríða Aradóttir | Key Hair Stylist |
| Art | Karen Schulz Gropman | Set Decoration |
| Sound | Bill Phillips | Supervising Sound Editor |
| Crew | Charles Croughwell | Stunt Coordinator |
| Crew | Kerrie Cullen | Stunts |
