Twee vrienden, de slimme George en de simpele, maar sterke Lennie, reizen tijdens de depressie van de jaren '20 door het Amerikaanse platteland, dromend van een beter leven. Ze krijgen ergens werk, maar raken in de problemen als Lennie in een incident met een meisje verwikkeld raakt.
Nee, helaas is Of Mice and Men nog niet beschikbaar op Netflix in Nederland.
| Writing | John Steinbeck | Novel |
| Production | Russell Smith | Producer |
| Sound | Mark Isham | Original Music Composer |
| Production | Alan C. Blomquist | Executive Producer |
| Directing | Gary Sinise | Director |
| Production | Gary Sinise | Producer |
| Camera | Kenneth MacMillan | Director of Photography |
| Writing | Horton Foote | Screenplay |
| Editing | Robert L. Sinise | Editor |
| Costume & Make-Up | Fríða Aradóttir | Key Hair Stylist |
| Production | Alan C. Blomquist | Unit Production Manager |
| Art | Karen Schulz Gropman | Set Decoration |
| Costume & Make-Up | Ann Pala | Assistant Makeup Artist |
| Directing | Cara Giallanza | First Assistant Director |
| Sound | Bill Phillips | Supervising Sound Editor |
| Directing | Michele Panelli-Venetis | Second Assistant Director |
| Costume & Make-Up | Bonita DeHaven | Makeup Artist |
| Art | Dan Davis | Art Direction |
| Art | Joyce Anne Gilstrap | Set Decoration |
| Crew | Howard Jensen | Special Effects |
| Sound | John Phillips | Supervising Sound Editor |
| Costume & Make-Up | Peggy Hannaman | Assistant Hairstylist |
| Crew | Charles Croughwell | Stunt Coordinator |
| Crew | Kerrie Cullen | Stunts |
