Twee vrienden, de slimme George en de simpele, maar sterke Lennie, reizen tijdens de depressie van de jaren '20 door het Amerikaanse platteland, dromend van een beter leven. Ze krijgen ergens werk, maar raken in de problemen als Lennie in een incident met een meisje verwikkeld raakt.
Nee, helaas is Of Mice and Men nog niet beschikbaar op Netflix in Nederland.
| Directing | Gary Sinise | Director |
| Writing | John Steinbeck | Novel |
| Writing | Horton Foote | Screenplay |
| Production | Gary Sinise | Producer |
| Production | Russell Smith | Producer |
| Production | Alan C. Blomquist | Executive Producer |
| Sound | Mark Isham | Original Music Composer |
| Camera | Kenneth MacMillan | Director of Photography |
| Editing | Robert L. Sinise | Editor |
| Production | Alan C. Blomquist | Unit Production Manager |
| Directing | Cara Giallanza | First Assistant Director |
| Directing | Michele Panelli-Venetis | Second Assistant Director |
| Art | Dan Davis | Art Direction |
| Art | Karen Schulz Gropman | Set Decoration |
| Art | Joyce Anne Gilstrap | Set Decoration |
| Costume & Make-Up | Bonita DeHaven | Makeup Artist |
| Costume & Make-Up | Fríða Aradóttir | Key Hair Stylist |
| Costume & Make-Up | Ann Pala | Assistant Makeup Artist |
| Costume & Make-Up | Peggy Hannaman | Assistant Hairstylist |
| Sound | John Phillips | Supervising Sound Editor |
| Sound | Bill Phillips | Supervising Sound Editor |
| Crew | Howard Jensen | Special Effects |
| Crew | Charles Croughwell | Stunt Coordinator |
| Crew | Kerrie Cullen | Stunts |
