Een groep strijders heeft zes dagen de tijd om de wereld te redden van de duivelse Shoa Kahn. Als ze hem en zijn strijders niet verslaan tijdens het tournooi Mortal Kombat zal de Aarde worden samengevoegd met Outworld, en zal Kahn de ultieme machthebber worden
Nee, helaas is Mortal Kombat: Annihilation nog niet beschikbaar op Netflix in Nederland.
| Directing | John R. Leonetti | Director |
| Production | Lawrence Kasanoff | Producer |
| Production | Brian Witten | Executive Producer |
| Crew | Dana Hee | Stunt Double |
| Crew | Dennis Keiffer | Stunts |
| Sound | David Farmer | Sound Designer |
| Crew | Mark Caso | Stunts |
| Crew | 谷垣健治 | Stunt Double |
| Crew | Tyrone C. Wiggins | Stunt Double |
| Costume & Make-Up | Shaune Harrison | Special Effects Makeup Artist |
| Costume & Make-Up | Gary Pollard | Makeup Effects Designer |
| Directing | Eddie Stacey | Second Unit Director |
| Crew | Eddie Stacey | Stunt Coordinator |
| Costume & Make-Up | Matt Jordon | Special Effects Makeup Artist |
| Crew | Tony Jaa | Stunt Double |
| Lighting | Logan Leabo | Gaffer |
| Crew | Keith Cooke | Stunts |
| Crew | Tyrone C. Wiggins | Stunts |
| Crew | Buster Reeves | Stunt Double |
| Directing | Apichart Chusakul | First Assistant Director |
| Directing | Lee Cleary | First Assistant Director |
| Crew | Ron Trost | Special Effects Coordinator |
| Crew | John Medlen | Stunts |
| Lighting | Pat Blymyer | Gaffer |
| Visual Effects | Joss Williams | Special Effects Supervisor |
| Crew | Theo Kypri | Stunts |
| Crew | Robin Shou | Fight Choreographer |
| Crew | Ed Boon | Video Game |
| Art | Simon Wakefield | Set Decoration |
| Crew | Jeff Hewitt-Davis | Stunts |
| Crew | Dennis Keiffer | Stunt Double |
| Camera | Christopher Faloona | Second Unit Director of Photography |
| Crew | John Tobias | Video Game |
| Crew | Joss Williams | Special Effects |
| Crew | Ridley Tsui Bo-wah | Stunts |
| Crew | Mark Caso | Stunt Double |
| Crew | Sultan Uddin | Stunts |
| Sound | Ken Teaney | Sound Re-Recording Mixer |
| Crew | Valentino Musetti | Stunts |
| Crew | Nikki Powell | Stunts |
| Crew | Pat E. Johnson | Stunt Coordinator |
| Crew | Nikki Powell | Stunt Double |
| Directing | Pat E. Johnson | Second Unit Director |
| Directing | Jamie Christopher | Second Assistant Director |
| Crew | J.J. Perry | Stunts |
| Crew | Ray Park | Stunt Double |
| Crew | Carlton Headley | Stunts |
| Crew | Theo Kypri | Stunt Double |
| Crew | Keith Cooke | Fight Choreographer |
| Sound | George S. Clinton | Original Music Composer |
| Production | Alison Savitch | Executive Producer |
| Production | Carla Fry | Executive Producer |
| Production | Kevin Reidy | Co-Producer |
| Production | Mark Paladini | Casting |
| Costume & Make-Up | Melissa Lackersteen | Key Makeup Artist |
| Writing | Joshua Wexler | Story |
| Production | Gerrit V. Folsom | Line Producer |
| Writing | Bryce Zabel | Screenplay |
| Writing | Brent V. Friedman | Screenplay |
| Editing | Peck Prior | Editor |
| Production | Joshua Wexler | Associate Producer |
| Writing | John Tobias | Story |
| Writing | Lawrence Kasanoff | Story |
| Production | Thom Fleming | Line Producer |
| Art | Nathan Schroeder | Art Direction |
| Costume & Make-Up | Michelle Taylor | Key Makeup Artist |
| Production | Fern Champion | Casting |
| Costume & Make-Up | Jennifer L. Parsons | Costume Design |
| Art | Charles Wood | Production Design |
| Camera | Matthew F. Leonetti | Director of Photography |
| Costume & Make-Up | Chris Lyons | Special Effects Makeup Artist |
