Een groep strijders heeft zes dagen de tijd om de wereld te redden van de duivelse Shoa Kahn. Als ze hem en zijn strijders niet verslaan tijdens het tournooi Mortal Kombat zal de Aarde worden samengevoegd met Outworld, en zal Kahn de ultieme machthebber worden
Nee, helaas is Mortal Kombat: Annihilation nog niet beschikbaar op Netflix in Nederland.
| Production | Lawrence Kasanoff | Producer |
| Directing | John R. Leonetti | Director |
| Production | Brian Witten | Executive Producer |
| Crew | Dana Hee | Stunt Double |
| Costume & Make-Up | Matt Jordon | Special Effects Makeup Artist |
| Directing | Pat E. Johnson | Second Unit Director |
| Crew | Carlton Headley | Stunts |
| Crew | Valentino Musetti | Stunts |
| Crew | J.J. Perry | Stunts |
| Crew | Ray Park | Stunt Double |
| Directing | Apichart Chusakul | First Assistant Director |
| Crew | Theo Kypri | Stunts |
| Costume & Make-Up | Gary Pollard | Makeup Effects Designer |
| Directing | Eddie Stacey | Second Unit Director |
| Crew | Tyrone C. Wiggins | Stunts |
| Crew | Keith Cooke | Fight Choreographer |
| Crew | Nikki Berwick | Stunts |
| Visual Effects | Joss Williams | Special Effects Supervisor |
| Crew | 谷垣健治 | Stunt Double |
| Crew | Eddie Stacey | Stunt Coordinator |
| Crew | Theo Kypri | Stunt Double |
| Crew | John Tobias | Video Game |
| Sound | Ken Teaney | Sound Re-Recording Mixer |
| Crew | 徐寶華 | Stunts |
| Crew | Tony Jaa | Stunt Double |
| Directing | Lee Cleary | First Assistant Director |
| Crew | Keith Cooke | Stunts |
| Costume & Make-Up | Shaune Harrison | Special Effects Makeup Artist |
| Crew | Mark Caso | Stunts |
| Crew | Tyrone C. Wiggins | Stunt Double |
| Lighting | Logan Leabo | Gaffer |
| Art | Simon Wakefield | Set Decoration |
| Crew | Nikki Berwick | Stunt Double |
| Crew | Ed Boon | Video Game |
| Crew | Jeff Hewitt-Davis | Stunts |
| Crew | Pat E. Johnson | Stunt Coordinator |
| Crew | Robin Shou | Fight Choreographer |
| Crew | Mark Caso | Stunt Double |
| Crew | Dennis Keiffer | Stunt Double |
| Camera | Christopher Faloona | Second Unit Director of Photography |
| Sound | David Farmer | Sound Designer |
| Crew | Ron Trost | Special Effects Coordinator |
| Crew | Dennis Keiffer | Stunts |
| Crew | John Medlen | Stunts |
| Lighting | Pat Blymyer | Gaffer |
| Directing | Jamie Christopher | Second Assistant Director |
| Crew | Joss Williams | Special Effects |
| Crew | Sultan Uddin | Stunts |
| Crew | Buster Reeves | Stunt Double |
| Sound | George S. Clinton | Original Music Composer |
| Production | Carla Fry | Executive Producer |
| Production | Alison Savitch | Executive Producer |
| Writing | Joshua Wexler | Story |
| Production | Joshua Wexler | Associate Producer |
| Costume & Make-Up | Melissa Lackersteen | Key Makeup Artist |
| Writing | Bryce Zabel | Screenplay |
| Production | Thom Fleming | Line Producer |
| Art | Nathan Schroeder | Art Direction |
| Production | Gerrit V. Folsom | Line Producer |
| Writing | Lawrence Kasanoff | Story |
| Costume & Make-Up | Jennifer L. Parsons | Costume Design |
| Costume & Make-Up | Michelle Taylor | Key Makeup Artist |
| Editing | Peck Prior | Editor |
| Writing | John Tobias | Story |
| Writing | Brent V. Friedman | Screenplay |
| Production | Mark Paladini | Casting |
| Production | Fern Champion | Casting |
| Art | Charles Wood | Production Design |
| Production | Kevin Reidy | Co-Producer |
| Camera | Matthew F. Leonetti | Director of Photography |
| Costume & Make-Up | Chris Lyons | Special Effects Makeup Artist |
