Het honkbalteam The Cleveland Indians heeft in 34 jaar geen succes behaald. Voormalig nachtclubdanseres Rachel Phelps trouwt de eigenaar van het team. Hij overleeft de huwelijksreis niet, en zij erft het team van hem. Zij haat Cleveland, en wil graag een nieuw stadion betrekken in een warmer klimaat, zoals Miami, Florida. De enige manier waarop zij onder het contract met Cleveland uit kan komen, is wanneer het bezoekersaantal onder de 800.000 komt. Om dat te bereiken stelt ze het slechts denkbare team samen. Wanneer het team er achter komt wat de bedoeling van Rachel Phelps is, besluiten ze terug te vechten.
Nee, helaas is Major League nog niet beschikbaar op Netflix in Nederland.
| Directing | David S. Ward | Director |
| Camera | Reynaldo Villalobos | Director of Photography |
| Production | Mark Rosenberg | Executive Producer |
| Production | Irby Smith | Producer |
| Production | Chris Chesser | Producer |
| Production | Joanne Zaluski | Casting |
| Production | Julie Bergman Sender | Co-Producer |
| Costume & Make-Up | Erica Edell Phillips | Costume Design |
| Art | Jeffrey Howard | Production Design |
| Sound | James Newton Howard | Original Music Composer |
| Crew | Rick LeFevour | Stunt Coordinator |
| Crew | G.A. Aguilar | Stunts |
| Crew | Alex Flores | Stunts |
| Crew | Stacy Logan | Stunts |
| Crew | Michael F. Twarog | Stunts |
| Crew | Ted White | Stunts |
| Production | Irby Smith | Unit Production Manager |
| Production | Edward D. Markley | Unit Production Manager |
| Directing | Jerry Grandey | First Assistant Director |
| Directing | Louis D'Esposito | First Assistant Director |
| Directing | Christine Larson | Second Assistant Director |
| Directing | Richard Patrick | Second Assistant Director |
| Editing | Tony Lombardo | Editor |
| Directing | Irby Smith | Second Unit Director |
| Camera | James Pergola | Second Unit Director of Photography |
| Art | John Krenz Reinhart Jr. | Art Direction |
| Art | Bill Rea | Set Designer |
| Art | Celeste Lee | Set Decoration |
| Art | Patrick Cassidy | Assistant Set Decoration |
| Crew | Dieter Sturm | Special Effects |
| Sound | Susumu Tokunow | Sound Mixer |
| Sound | Laura Derrick | Boom Operator |
| Costume & Make-Up | Michael Becker | Costume Supervisor |
| Costume & Make-Up | Laurie Hudson | Wardrobe Supervisor |
| Costume & Make-Up | Sherrie Brody | Wardrobe Assistant |
| Costume & Make-Up | Patti Cameron | Wardrobe Assistant |
| Costume & Make-Up | Frances Mathias | Hairstylist |
| Costume & Make-Up | John Wabisca | Makeup Artist |
| Costume & Make-Up | Peggy Teague | Makeup & Hair Assistant |
| Costume & Make-Up | Judith Denny | Makeup & Hair Assistant |
| Editing | Dennis M. Hill | Editor |
| Sound | Randy Newman | Songs |
| Writing | David S. Ward | Writer |
